Analysis Tools|
Allele Symbol Allele Name Allele ID |
Hoxd13+ wild type MGI:2153083 |
||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Summary |
13 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• a subtle reduction in the length of the second phalanges in digits II and V is scored in approximately 30% of the cases
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• disorganization of the internal anal sphincter
|
|
• disorganization of the internal anal sphincter
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• heterozygotes exhibit minor carpal defects, including a slight indentation at the distal border
|
|
• heterozygotes display a tiny bony element located postaxially to digit V at a penetrance of 36%
|
|
• heterozygotes exhibit minor carpal defects, including a slight indentation at the distal border
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• postminimus in 80% of trans-heterozygous mice
|
|
• reduction in digit size of trans-heterozygous mice is most prominent in the second phalanges
|
|
• trans-heterozygous mice exhibit a reduction of digits V and II in the forelimbs
|
|
• reduction in digit size of trans-heterozygous mice is most prominent in the second phalanges
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mice are not recovered after E14.5
|
|
• with the exception of an altered pisiform cartilage, there is no individualization of carpal condensation
|
|
• digits lack separation and segmentation and tend to fuse terminally
• mice lack digit I and some mice have a minute posterior extra digit cartilage
|
|
• the tarsus is altered more than in Hoxa13tm1Ipc/ Hoxa13+ Hoxd13tm1Ddu/Hoxd13tm1Ddu mice
• none of the tarsus blastemas are properly individualized and there is no separation between proximal and distal rows
|
|
• in the hindlimbs condensations for digits I through V are apparent but are irregular and remain in a primitive state
• in the hindlimbs, there is no chondrification in digit rays II and V
|
|
• foot plates are narrower, especially towards the distal extremities, when compared with Hoxa13tm1Ipc/ Hoxa13+ Hoxd13tm1Ddu/Hoxd13tm1Ddu mice
|
|
• with the exception of an altered pisiform cartilage, there is no individualization of carpal condensation
|
|
• the tarsus is altered more than in Hoxa13tm1Ipc/ Hoxa13+ Hoxd13tm1Ddu/Hoxd13tm1Ddu mice
• none of the tarsus blastemas are properly individualized and there is no separation between proximal and distal rows
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mice are not recovered after E14.5
|
|
• with the exception of an altered pisiform cartilage, there is no individualization of carpal condensation
|
|
• digits lack separation and segmentation and tend to fuse terminally
• mice lack digit I and some mice have a minute posterior extra digit cartilage
|
|
• the tarsus is altered more than in Hoxa13tm2Ipc/ Hoxa13+ Hoxd13tm1Ddu/Hoxd13tm1Ddu mice
• none of the tarsus blastemas are properly individualized and there is no separation between proximal and distal rows
|
|
• in the hindlimbs condensations for digits I through V are apparent but are irregular and remain in a primitive state
• in the hindlimbs, there is no chondrification in digit rays II and V
|
|
• foot plates are narrower, especially towards the distal extremities, when compared with Hoxa13tm2Ipc/ Hoxa13+ Hoxd13tm1Ddu/Hoxd13tm1Ddu mice
|
|
• with the exception of an altered pisiform cartilage, there is no individualization of carpal condensation
|
|
• the tarsus is altered more than in Hoxa13tm2Ipc/ Hoxa13+ Hoxd13tm1Ddu/Hoxd13tm1Ddu mice
• none of the tarsus blastemas are properly individualized and there is no separation between proximal and distal rows
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• in 50% of mice, the fourth posterior distal carpal bone is partly or fully split into two distinct bone
|
|
• digits I and V are deformed in the hinblimb
• digit I is more truncated than normal and no first phalanx is visible
• digit I in the hindlimb has its first phalanx truncated and the terminal phalanx has an altered bell-shaped morphology
• the second phalanges of digits II and mostly in digit V are truncated in the forelimbs and hindlimbs
• digits II and III are fused and alterations in the claw of digit I are observeddigits II and III are fused and alterations in the claw of digit I are observed
• newborn mice show an incomplete segmentation between phalangeal cartilage in digit I
|
|
• digit I lacks a first phalanx and newborn mice show an incomplete segmentation between the two phalangeal cartilages in forelimbs and in some hindlimbs
• digit I in the hindlimb has its first phalanx truncated and the terminal phalanx has an altered bell-shaped morphology
• the second phalanges of digits II and mostly in digit V are truncated in the forelimbs and hindlimbs
|
|
• in adults, digits I, II and V are truncated
|
|
• 23 of 40 mice have an extra posterior digit in the forelimbs consisting of either a small floating bone distal to the post minimus or an entire small digit
|
|
• in adults, digits III and IV are partially fused in the forelimbs and digits II, III and IV are completely fused in the hindlimbs
|
|
• the metatarsal of digit I is elongated
|
|
• in 50% of mice, the fourth posterior distal carpal bone is partly or fully split into two distinct bone
|
|
• digit I lacks a first phalanx and newborn mice show an incomplete segmentation between the two phalangeal cartilages in forelimbs and in some hindlimbs
• digit I in the hindlimb has its first phalanx truncated and the terminal phalanx has an altered bell-shaped morphology
• the second phalanges of digits II and mostly in digit V are truncated in the forelimbs and hindlimbs
|
|
• the metatarsal of digit I is elongated
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• in 50% of mice, the fourth posterior distal carpal bone is partly or fully split into two distinct bone
|
|
• digits I and V are deformed in the hinblimb
• digit I is more truncated than normal and no first phalanx is visible
• newborn mice show an incomplete segmentation between phalangeal cartilage in digit I
• digit I in the hindlimb has its first phalanx truncated and the terminal phalanx has an altered bell-shaped morphology
• the second phalanges of digits II and mostly in digit V are truncated in the forelimbs and hindlimbs
• digits II and III are fused and alterations in the claw of digit I are observeddigits II and III are fused and alterations in the claw of digit I are observed
|
|
• digit I lacks a first phalanx and newborn mice show an incomplete segmentation between the two phalangeal cartilages in forelimbs and in some hindlimbs
• digit I in the hindlimb has its first phalanx truncated and the terminal phalanx has an altered bell-shaped morphology
• the second phalanges of digits II and mostly in digit V are truncated in the forelimbs and hindlimbs
|
|
• in adults, digits I, II and V are truncated
|
|
• 23 of 40 mice have an extra posterior digit in the forelimbs consisting of either a small floating bone distal to the post minimus or an entire small digit
|
|
• in adults, digits III and IV are partially fused in the forelimbs and digits II, III and IV are completely fused in the hindlimbs
|
|
• the metatarsal of digit I is elongated
|
|
• in 50% of mice, the fourth posterior distal carpal bone is partly or fully split into two distinct bone
|
|
• digit I lacks a first phalanx and newborn mice show an incomplete segmentation between the two phalangeal cartilages in forelimbs and in some hindlimbs
• digit I in the hindlimb has its first phalanx truncated and the terminal phalanx has an altered bell-shaped morphology
• the second phalanges of digits II and mostly in digit V are truncated in the forelimbs and hindlimbs
|
|
• the metatarsal of digit I is elongated
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• the second phalanges is reduced or absent compared to in wild-type mice
|
|
• digits II and V are shorter than in wild-type mice due to a reduction or absence of the second phalanges
|
|
• the second phalanges is reduced or absent compared to in wild-type mice
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• less pronounced than in homozygotes of either component mutation
|
|
• variable syndactyly of digits III and IV, along with a supernumerary digit in between
|
 |
• although males homozygous for either mutation are sterile, approximately 60% of these trans-heterozygotes are fertile
|
|
• at 8 days of age the paws have some delay in the ossification process although ossification centers are observed
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 03/18/2025 MGI 6.24 |
|
|
|
||
