All Phenotypes Ednrb<+> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ednrb⁺
wild type
MGI:2152787

Summary

34 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Ednrb^s-4Chlc/Ednrb⁺	involves: 101/Rl * C3H/Rl	MGI:3850226
ht2	Ednrb^s-4Pub/Ednrb⁺	involves: 101/Rl * C3H/Rl	MGI:3850244
ht3	Ednrb^s-36Pub/Ednrb⁺	involves: 101/Rl * C3H/Rl	MGI:3850248
ht4	Ednrb^s-31Pub/Ednrb⁺	involves: 101/Rl * C3H/Rl	MGI:3850323
ht5	Ednrb^s-3Etopf/Ednrb⁺	involves: 101/Rl * C3H/Rl	MGI:3850326
ht6	Ednrb^s-48UThc/Ednrb⁺	involves: 101/Rl * C3H/Rl	MGI:3850331
ht7	Ednrb^s-4Blec/Ednrb⁺	involves: 101/Rl * C3H/Rl	MGI:3850336
ht8	Ednrb^s-52Pub/Ednrb⁺	involves: 101/Rl * C3H/Rl	MGI:3850341
ht9	Ednrb^s-9ThW/Ednrb⁺	involves: 101/Rl * C3H/Rl	MGI:3850346
ht10	Ednrb^s-17Pub/Ednrb⁺	involves: 101/Rl * C3H/Rl	MGI:3777950
ht11	Ednrb^s-1Acrg/Ednrb⁺	involves: 101/Rl * C3H/Rl	MGI:3777961
ht12	Ednrb^s-1MLPf/Ednrb⁺	involves: 101/Rl * C3H/Rl	MGI:3777970
ht13	Ednrb^s-1Pu/Ednrb⁺	involves: 101/Rl * C3H/Rl	MGI:3777973
ht14	Ednrb^s-1XMLP/Ednrb⁺	involves: 101/Rl * C3H/Rl	MGI:3777987
ht15	Ednrb^s-1XMLPc/Ednrb⁺	involves: 101/Rl * C3H/Rl	MGI:3777989
ht16	Ednrb^s-24Pub/Ednrb⁺	involves: 101/Rl * C3H/Rl	MGI:3777992
ht17	Ednrb^s-27Pu/Ednrb⁺	involves: 101/Rl * C3H/Rl	MGI:3777995
ht18	Ednrb^s-29Pub/Ednrb⁺	involves: 101/Rl * C3H/Rl	MGI:3778003
ht19	Ednrb^s-2CHLd/Ednrb⁺	involves: 101/Rl * C3H/Rl	MGI:3778008
ht20	Ednrb^s-2Etopc/Ednrb⁺	involves: 101/Rl * C3H/Rl	MGI:3778012
ht21	Ednrb^s-2MLPl/Ednrb⁺	involves: 101/Rl * C3H/Rl	MGI:3778017
ht22	Ednrb^s-15DttMb/Ednrb⁺	involves: 101/Rl * C3H/Rl	MGI:3850210
ht23	Ednrb^s-13Pub/Ednrb⁺	involves: 101/Rl * C3H/Rl	MGI:3777930
ht24	Ednrb^tm1.1Nrd/Ednrb⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5804452
ht25	Ednrb^tm1Ywa/Ednrb⁺	involves: 129S/SvEvBrd	MGI:3717430
cx26	Ednrb^s-36Pub/Ednrb⁺ Spry2^tm1.1Mrt/Spry2⁺	involves: 101/Rl * 129P2/OlaHsd * C3H/Rl * C57BL/6J	MGI:3759579
cx27	Ednrb^s-15DttMb/Ednrb⁺ Mycbp2^tm1.1Adia/Mycbp2⁺	involves: 101/Rl * C3H/Rl * C57BL/6 * FVB/N	MGI:3760666
cx28	Ednrb^s-24Pub/Ednrb⁺ m174-16Tpo/m174-16Tpo⁺	involves: 101/Rl * C3H/Rl * C57BL/6J * SSL/LeJ	MGI:3849715
cx29	Ednrb^s-24Pub/Ednrb⁺ m128-7Tpo/m128-7Tpo⁺	involves: 101/Rl * C3H/Rl * C57BL/6J * SSL/LeJ	MGI:3849718
cx30	Ednrb^s-24Pub/Ednrb⁺ m183-15Tpo/m183-15Tpo⁺	involves: 101/Rl * C3H/Rl * C57BL/6J * SSL/LeJ	MGI:3849720
cx31	Ednrb^s-24Pub/Ednrb⁺ m251-2Tpo/m251-2Tpo⁺	involves: 101/Rl * C3H/Rl * C57BL/6J * SSL/LeJ	MGI:3849722
cx32	Ednrb^s-24Pub/Ednrb⁺ m283-1Tpo/m283-1Tpo⁺	involves: 101/Rl * C3H/Rl * C57BL/6J * SSL/LeJ	MGI:3849726
cx33	Ednrb^s-24Pub/Ednrb⁺ Mycbp2^m274-4Tpo/Mycbp2⁺	involves: 101/Rl * C3H/Rl * C57BL/6J * SSL/LeJ	MGI:3849713
cx34	Ednrb^tm1Ywa/Ednrb⁺ Tg(Mt1-RET)304Ina/0	involves: 129S7/SvEvBrd * BALB/c * C57BL/6	MGI:5303093

Allelic Composition	Ednrb^s-4Chlc/Ednrb⁺
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrb^s-4Chlc mutation (1 available); any Ednrb mutation (105 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:100221 )

• described as small and runted

Allelic Composition	Ednrb^s-4Pub/Ednrb⁺
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrb^s-4Pub mutation (1 available); any Ednrb mutation (105 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:100221 )

• described as small and runted

Allelic Composition	Ednrb^s-36Pub/Ednrb⁺
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrb^s-36Pub mutation (0 available); any Ednrb mutation (105 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:100221 )

• described as small and runted

Allelic Composition	Ednrb^s-31Pub/Ednrb⁺
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrb^s-31Pub mutation (1 available); any Ednrb mutation (105 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:100221 )

• described as small and runted

Allelic Composition	Ednrb^s-3Etopf/Ednrb⁺
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrb^s-3Etopf mutation (1 available); any Ednrb mutation (105 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:100221 )

• described as small and runted

Allelic Composition	Ednrb^s-48UThc/Ednrb⁺
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrb^s-48UThc mutation (1 available); any Ednrb mutation (105 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:100221 )

• described as small and runted

Allelic Composition	Ednrb^s-4Blec/Ednrb⁺
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrb^s-4Blec mutation (1 available); any Ednrb mutation (105 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:100221 )

• described as small and runted

Allelic Composition	Ednrb^s-52Pub/Ednrb⁺
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrb^s-52Pub mutation (2 available); any Ednrb mutation (105 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:100221 )

• described as small and runted

Allelic Composition	Ednrb^s-9ThW/Ednrb⁺
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrb^s-9ThW mutation (1 available); any Ednrb mutation (105 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:100221 )

• described as small and runted

Allelic Composition	Ednrb^s-17Pub/Ednrb⁺
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrb^s-17Pub mutation (0 available); any Ednrb mutation (105 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:100221 )

• described as small and runted

Allelic Composition	Ednrb^s-1Acrg/Ednrb⁺
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrb^s-1Acrg mutation (0 available); any Ednrb mutation (105 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:100221 )

• described as small and runted

Allelic Composition	Ednrb^s-1MLPf/Ednrb⁺
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrb^s-1MLPf mutation (1 available); any Ednrb mutation (105 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:100221 )

• described as small and runted

Allelic Composition	Ednrb^s-1Pu/Ednrb⁺
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrb^s-1Pu mutation (1 available); any Ednrb mutation (105 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:100221 )

• described as small and runted

Allelic Composition	Ednrb^s-1XMLP/Ednrb⁺
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrb^s-1XMLP mutation (1 available); any Ednrb mutation (105 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:100221 )

• described as small and runted

Allelic Composition	Ednrb^s-1XMLPc/Ednrb⁺
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrb^s-1XMLPc mutation (1 available); any Ednrb mutation (105 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:100221 )

• described as small and runted

Allelic Composition	Ednrb^s-24Pub/Ednrb⁺
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrb^s-24Pub mutation (0 available); any Ednrb mutation (105 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:100221 )

• described as small and runted

Allelic Composition	Ednrb^s-27Pu/Ednrb⁺
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrb^s-27Pu mutation (1 available); any Ednrb mutation (105 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:100221 )

• described as small and runted

Allelic Composition	Ednrb^s-29Pub/Ednrb⁺
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrb^s-29Pub mutation (1 available); any Ednrb mutation (105 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:100221 )

• described as small and runted

Allelic Composition	Ednrb^s-2CHLd/Ednrb⁺
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrb^s-2CHLd mutation (1 available); any Ednrb mutation (105 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:100221 )

• described as small and runted

Allelic Composition	Ednrb^s-2Etopc/Ednrb⁺
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrb^s-2Etopc mutation (1 available); any Ednrb mutation (105 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:100221 )

• described as small and runted

Allelic Composition	Ednrb^s-2MLPl/Ednrb⁺
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrb^s-2MLPl mutation (1 available); any Ednrb mutation (105 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:100221 )

• described as small and runted

Allelic Composition	Ednrb^s-15DttMb/Ednrb⁺
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrb^s-15DttMb mutation (0 available); any Ednrb mutation (105 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:100221 )

• described as small, runted

Allelic Composition	Ednrb^s-13Pub/Ednrb⁺
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrb^s-13Pub mutation (1 available); any Ednrb mutation (105 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:100221 )

• described as small and runted

Allelic Composition	Ednrb^tm1.1Nrd/Ednrb⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrb^tm1.1Nrd mutation (0 available); any Ednrb mutation (105 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Under severe hypoxia, the relative hypoxic area in the heart is lower in Ednrb^tm1.1Nrd/Ednrb⁺ mice

homeostasis/metabolism

decreased response of heart to induced stress ( J:226561 )

• under severe hypoxia (10% or 5% O₂), heterozygotes maintain a steady (and thus higher) cardiac output relative to wild-type controls where cardiac output is decreased to about half of baseline levels

• heterozygotes exhibit a higher dP/dt_max/V_ed value, indicating higher cardiac contractility, at baseline as well as under all hypoxia exposures (15%, 10% or 5% O₂) relative to wild-type controls

abnormal blood pH regulation ( J:226561 )

• under severe hypoxia, blood is significantly less acidic than in wild-type controls

decreased circulating lactate level ( J:226561 )

• below 15% O₂ exposure, heterozygotes show only a mild (smaller) increase in blood lactate levels (1.8 +/- 0.75 mmol/L at 10%; 2.28 0.38 mmol/L at 5%) relative to wild-type controls (4.01 +/- 1.05 mmol/L at 10%; 4.92 +/- 0.33 mmol/L at 5%)

• at 5% O₂ exposure, heterozygous blood lactate levels are less than half of those in wild-type controls

• however, no significant differences are noted at room air or 15% O₂

hypocapnia ( J:226561 )

• heterozygotes display a significantly lower partial CO₂ pressure at room air (21% O₂), but not under 15%, 10% or 5% hypoxia, relative to wild-type controls

abnormal oxygen level ( J:226561 )

• under 5% O₂ exposure, heterozygotes show a significant decrease in the relative hypoxic area (%) in brain, heart, and kidney tissue relative to wild-type controls, as shown by pimonidazole staining; this difference is more significant in heart tissue

• however, no significant differences are seen in the intestine or liver

cardiovascular system

increased cardiac output ( J:226561 )

• in response to severe hypoxia (10% or 5% O₂), heterozygotes show no significant change in cardiac output, unlike wild-type controls where cardiac output is reduced to about half of baseline levels

• however, no significant differences are observed at baseline or under mild hypoxia (21% or 15% O₂) relative to wild-type controls

increased heart ventricle muscle contractility ( J:226561 )

• heterozygotes exhibit a higher dP/dt_max/V_ed (maximum rate of pressure change per ventricular end-diastolic volume) at baseline as well as under all subsequent hypoxia exposures (15%, 10% or 5% O₂) relative to wild-type controls

decreased response of heart to induced stress ( J:226561 )

increased mean systemic arterial blood pressure ( J:226561 )

• in response to 30 min of severe hypoxia (5% O₂), all heterozygotes show tolerance to hypoxia-induced hypotension (defined as MAP <40 mmHg) displaying an average MAP 60.5 +/- 53 mmHg, whereas none of wild-type controls are able to maintain MAP >40 mmHg for the entire 30-min period

muscle

increased heart ventricle muscle contractility ( J:226561 )

Allelic Composition	Ednrb^tm1Ywa/Ednrb⁺
Genetic Background	involves: 129S/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrb^tm1Ywa mutation (4 available); any Ednrb mutation (105 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased acute inflammation ( J:103977 )

• inflammatory response to topical application of arachidonic acid is reduced by 37 or 51%

• pruritic response is normal

behavior/neurological

hypoalgesia ( J:103977 )

• algesic response to phenylbenzoquinone is reduced by 80%

Allelic Composition	Ednrb^s-36Pub/Ednrb⁺ Spry2^tm1.1Mrt/Spry2⁺
Genetic Background	involves: 101/Rl * 129P2/OlaHsd * C3H/Rl * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrb^s-36Pub mutation (0 available); any Ednrb mutation (105 available)
Spry2^tm1.1Mrt mutation (1 available); any Spry2 mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

abnormal palatal rugae morphology ( J:125229 )

• rugae morphology is disorganized and fragmented in cleft palate, whereas wild-type palates exhibit orderly array of 7-9 rugae

cleft secondary palate ( J:125229 )

• compound mutants display 35% incidence of cleft secondary palate

digestive/alimentary system

abnormal palatal rugae morphology ( J:125229 )

• rugae morphology is disorganized and fragmented in cleft palate, whereas wild-type palates exhibit orderly array of 7-9 rugae

cleft secondary palate ( J:125229 )

• compound mutants display 35% incidence of cleft secondary palate

growth/size/body

abnormal palatal rugae morphology ( J:125229 )

• rugae morphology is disorganized and fragmented in cleft palate, whereas wild-type palates exhibit orderly array of 7-9 rugae

cleft secondary palate ( J:125229 )

• compound mutants display 35% incidence of cleft secondary palate

Allelic Composition	Ednrb^s-15DttMb/Ednrb⁺ Mycbp2^tm1.1Adia/Mycbp2⁺
Genetic Background	involves: 101/Rl * C3H/Rl * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrb^s-15DttMb mutation (0 available); any Ednrb mutation (105 available)
Mycbp2^tm1.1Adia mutation (0 available); any Mycbp2 mutation (221 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal nervous system morphology ( J:125702 )

• authors state that mice exhibit the same gross morphological defects as observed in Phr1^tm1.1Adia homozygotes

Allelic Composition	Ednrb^s-24Pub/Ednrb⁺ m174-16Tpo/m174-16Tpo⁺
Genetic Background	involves: 101/Rl * C3H/Rl * C57BL/6J * SSL/LeJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrb^s-24Pub mutation (0 available); any Ednrb mutation (105 available)
m174-16Tpo mutation (0 available); any m174-16Tpo mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:149893 )

• mice die between E16.5 and E18.5

Allelic Composition	Ednrb^s-24Pub/Ednrb⁺ m128-7Tpo/m128-7Tpo⁺
Genetic Background	involves: 101/Rl * C3H/Rl * C57BL/6J * SSL/LeJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrb^s-24Pub mutation (0 available); any Ednrb mutation (105 available)
m128-7Tpo mutation (0 available); any m128-7Tpo mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Developmental defects of Ednrb^s-24Pub/Ednrb⁺ m128-7Tpo/m128-7Tpo⁺ embryos

mortality/aging

embryonic lethality, complete penetrance ( J:149893 )

• mice die mid-gestation

embryo

abnormal vitelline vasculature morphology ( J:149893 )

• at E10.5, yolk sacs lack mature blood vessels unlike in wild-type mice

abnormal pharyngeal arch morphology ( J:149893 )

• at E10.5

incomplete embryo turning ( J:149893 )

• at E10.5

cardiovascular system

abnormal vitelline vasculature morphology ( J:149893 )

• at E10.5, yolk sacs lack mature blood vessels unlike in wild-type mice

abnormal direction of heart looping ( J:149893 )

• randomized

hemopericardium ( J:149893 )

• at E10.5

enlarged pericardium ( J:149893 )

• at E10.5

craniofacial

abnormal pharyngeal arch morphology ( J:149893 )

• at E10.5

homeostasis/metabolism

hemopericardium ( J:149893 )

• at E10.5

growth/size/body

abnormal head morphology ( J:149893 )

• at E10.5

Allelic Composition	Ednrb^s-24Pub/Ednrb⁺ m183-15Tpo/m183-15Tpo⁺
Genetic Background	involves: 101/Rl * C3H/Rl * C57BL/6J * SSL/LeJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrb^s-24Pub mutation (0 available); any Ednrb mutation (105 available)
m183-15Tpo mutation (0 available); any m183-15Tpo mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:149893 )

• mice die by E7.5

Allelic Composition	Ednrb^s-24Pub/Ednrb⁺ m251-2Tpo/m251-2Tpo⁺
Genetic Background	involves: 101/Rl * C3H/Rl * C57BL/6J * SSL/LeJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrb^s-24Pub mutation (0 available); any Ednrb mutation (105 available)
m251-2Tpo mutation (0 available); any m251-2Tpo mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:149893 )

• mice die prior to weaning

Allelic Composition	Ednrb^s-24Pub/Ednrb⁺ m283-1Tpo/m283-1Tpo⁺
Genetic Background	involves: 101/Rl * C3H/Rl * C57BL/6J * SSL/LeJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrb^s-24Pub mutation (0 available); any Ednrb mutation (105 available)
m283-1Tpo mutation (0 available); any m283-1Tpo mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:149893 )

• mice die prior to weaning

Allelic Composition	Ednrb^s-24Pub/Ednrb⁺ Mycbp2^m274-4Tpo/Mycbp2⁺
Genetic Background	involves: 101/Rl * C3H/Rl * C57BL/6J * SSL/LeJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrb^s-24Pub mutation (0 available); any Ednrb mutation (105 available)
Mycbp2^m274-4Tpo mutation (0 available); any Mycbp2 mutation (221 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:149893 )

• mice die of respiratory distress at birth

respiratory system

respiratory distress ( J:149893 )

Allelic Composition	Ednrb^tm1Ywa/Ednrb⁺ Tg(Mt1-RET)304Ina/0
Genetic Background	involves: 129S7/SvEvBrd * BALB/c * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrb^tm1Ywa mutation (4 available); any Ednrb mutation (105 available)
Tg(Mt1-RET)304Ina mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased tumor-free survival time ( J:155735 )

• life span after tumor development is shorter than in single Tg(Mt1-RET)304Ina hemizygotes

neoplasm

increased metastatic potential ( J:155735 )

• lung metastasis after tumor development is significantly higher than in Tg(Mt1-RET)304Ina hemizygotes

increased melanoma incidence ( J:155735 )

• melanomagenesis proceeds without a pre-existing benign lesion, indicating de novo melanoma development

• location and shape of tumors is similar to those in single Tg(Mt1-RET)304Ina hemizygotes

• 68.8% of tumors less than 500 mm³ in size are malignant and the rest (31.2%) are premalignant

• 80.8% tumors from mutants are malignant and the rest are premalignant

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
melanoma		DOID:1909		J:155735

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/18/2025 MGI 6.24