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Allele Symbol Allele Name Allele ID |
Gnastm1Lsw targeted mutation 1, Lee S Weinstein MGI:2152743 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• when the allele is inherited paternally, mice treated with a V2 receptor-selective vasopressin agonist exhibit reduced urine osmolarity compared to in similarly treated wild-type mice
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• when the allele is inherited paternally, mice treated with a V2 receptor-selective vasopressin agonist exhibit reduced urine osmolarity compared to in similarly treated wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the few mice that survive to weaning are fertile with normal life spans
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• when the allele is inherited paternally, 77% of mice die within the first 24 hours after birth
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• when the allele is inherited maternally, 80% of mice die between 7 and 21 days of birth
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• when the allele is inherited maternally, ears are round and inset unlike in wild-type mice
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• when the allele is inherited paternally, mice exhibit narrow bodies compared to wild-type mice
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• when the allele is inherited paternally
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• when the allele is inherited maternally, mice have wide, square bodies compared with wild-type mice
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• when the allele is inherited maternally
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• by day 60 when the allele is inherited paternally
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• by day 60 when the allele is inherited maternally
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• when the allele is inherited paternally, mice are leaner than normal
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• within days of birth mice inheriting the allele maternally tend towards obese and mice inheriting the allele paternally are lean
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• at weaning, mice exhibit reduced body weight regardless of allele inheritance
• at 4 to 8 months, mice that inherit the allele paternally exhibit reduced body weight compared with wild-type mice
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• regardless of allele inheritance, body length is 90% of wild-type
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• in the few surviving mice regardless of allele inheritence
(J:49340)
• regardless of allele inheritance
(J:60971)
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• when the allele is inherited paternally, 77% of mice do not suckle milk unlike wild-type mice
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• when the allele is inherited maternally, 80% of mice exhibit poor righting reflex between 7 and 21 days of birth unlike wild-type mice
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• when the allele is inherited maternally, 80% of mice develop tremors between 7 and 21 days of birth unlike wild-type mice
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• when the allele is inherited maternally, 80% of mice develop ataxia between 7 and 21 days of birth unlike wild-type mice
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• when the allele is inherited maternally, 80% of mice develop imbalance between 7 and 21 days of birth unlike wild-type mice
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• when the allele is inherited paternally, mice exhibit arched back unlike in wild-type mice
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• when the allele is inherited maternally, mice exhibit reduced ambulatory activity compared with wild-type mice
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• when the allele is inherited paternally, mice exhibit increased total and ambulatory activity compared with wild-type mice
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• when the allele is inherited paternally, 77% of mice become inactive unlike wild-type mice
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| N |
• mice exhibit normal serum thyroid stimulating hormone, T3, and T4 levels
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• when the allele is inherited maternally
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• when the allele is inherited paternally
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• when the allele is inherited paternally
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• when the allele is inherited maternally
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• regardless of allele inheritance, DOPA levels are elevated in the urine compared to in wild-type mice
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• when the allele is inherited maternally, urine norepinepherine levels are 20% less than in wild-type mice
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• when the allele is inherited paternally, urine norepinepherine levels are 20% more than in wild-type mice
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• when the allele is inherited maternally
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• when the allele is inherited maternally, resting metabolic rate at 21 degrees Celsius in older mice, as measured by oxygen consumption, is 28% less than in wild-type mice
• when the allele is inherited maternally, resting metabolic rate at 21 degrees Celsius in older mice, as measured by oxygen consumption, is less than in wild-type mice
• however, oxygen consumption at 30 degrees Celsius is normal
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• when the allele is inherited paternally, resting metabolic rate at 21 degrees Celsius in older mice, as measured by oxygen consumption, is 23% greater than in wild-type mice
• when the allele is inherited paternally, resting metabolic rate at 30 degrees Celsius, as measured by oxygen consumption, is increased compared to in similarly treated wild-type mice
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• in fasting mice inheriting the allele maternally
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• in fasting mice regardless of allele inheritance
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• regardless of allele inheritance, overall the glucose curve is decreased although the return towards the base-line glucose levels is more pronounced in mice that inherit the allele paternally
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• regardless of allele inheritance, the hypoglycemic response to insulin injection is greater than in wild-type mice
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• when the allele is inherited maternally
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• regardless of allele inheritance, muscular glucose uptake in the presence of insulin is greater (55% and 48% when the allele is inherited paternally or maternally, respectively) than in similarly treated wild-type mice
• however, basal glucose uptake in the muscle is normal
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• imprinting of the allele varies in different organs with imprinting in the adipose tissue, parental imprinting in the renal cortex, and no imprinting in the renal inner medulla
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• when the allele is inherited maternally, ears are round and inset unlike in wild-type mice
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• when the allele is inherited maternally, thymic cortical atrophy is observed unlike in wild-type mice
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• when the allele is inherited maternally, development of the cerebellar cortex is delayed with persistence of superficial granular cells unlike in wild-type mice
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• regardless of allele inheritance, DOPA levels are elevated in the urine compared to in wild-type mice
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• when the allele is inherited maternally, urine norepinepherine levels are 20% less than in wild-type mice
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• when the allele is inherited paternally, urine norepinepherine levels are 20% more than in wild-type mice
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• when the allele is inherited maternally, mice exhibit immature kidneys unlike in wild-type mice
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• when the allele is inherited maternally, ears are round and inset unlike in wild-type mice
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• when the allele is inherited maternally, thymic cortical atrophy is observed unlike in wild-type mice
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• regardless of allele inheritance, muscular glucose uptake in the presence of insulin is greater (55% and 48% when the allele is inherited paternally or maternally, respectively) than in similarly treated wild-type mice
• however, basal glucose uptake in the muscle is normal
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• when the allele is inherited paternally, white adipose tissue lipid per cell is decreased compared to in wild-type mice
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• when the allele is inherited paternally, white adipose tissue lipid per cell is increased compared to in wild-type mice
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• when the allele is inherited paternally, brown adipose tissue pads are more brown than in wild-type mice 2 days after birth
• when the allele is inherited maternally, brown adipose tissue pads are lighter than in wild-type mice 2 days after birth
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• when the allele is inherited paternally, brown adipose tissue pads are smaller than in wild-type mice 2 days after birth
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• when the allele is inherited maternally, brown adipose tissue pads are larger than in wild-type mice 2 days after birth
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• when the allele is inherited maternally
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• when the allele is inherited paternally, epididymal white adipose tissue pad weight is decreased compared to in wild-type mice
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• when the allele is inherited paternally, interscapular brown adipose tissue pad weight is decreased compared to in wild-type mice
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• when the allele is inherited maternally, interscapular brown adipose tissue pad weight is increased compared to in wild-type mice
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• when the allele is inherited maternally, surviving mice exhibit convex skin folds on the dorsal neck unlike in wild-type mice
• when the allele is inherited paternally, surviving mice exhibit concave skin folds on the dorsal neck unlike in wild-type mice
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• when the allele is inherited maternally
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• when the allele is inherited maternally, thymic cortical atrophy is observed unlike in wild-type mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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