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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rag2+
wild type
MGI:2152734
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Apoetm1Unc/Apoetm1Unc
Rag2tm1Fwa/Rag2+ 		involves: 129P2/OlaHsd * 129S/SvEv MGI:3789200
cx2
 		Il2tm1Hor/Il2tm1Hor
Rag2tm1Fwa/Rag2+ 		involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 MGI:3759417
cx3
 		Rag2tm1Fwa/Rag2+
Trp53tm1Tyj/Trp53tm1Tyj 		involves: 129S/SvEv * 129S2/SvPas * C57BL/6J MGI:2665119
cx4
 		Rag2tm1Fwa/Rag2+
Tg(LPV-TAg1135)11Tvd/0 		involves: 129S/SvEv * C57BL/6 * DBA/2 MGI:2665131


Genotype
MGI:3789200
cx1
Allelic
Composition		 Apoetm1Unc/Apoetm1Unc
Rag2tm1Fwa/Rag2+
Genetic
Background		 involves: 129P2/OlaHsd * 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation (35 available); any Apoe mutation (164 available)
Rag2tm1Fwa mutation (45 available); any Rag2 mutation (115 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body weight ( J:59156 )
• body weight of mice treated with estradiol is reduced relative to that of untreated controls

reproductive system
increased uterus weight ( J:59156 )
• in response to estradiol treatment

homeostasis/metabolism
decreased circulating cholesterol level ( J:59156 )
• reduced total cholesterol in response to estradiol treatment
decreased circulating HDL cholesterol level ( J:59156 )
• in response to estradiol treatment

cardiovascular system
abnormal aorta morphology ( J:59156 )
• decreased fatty streak lesions in the aortic root in response to estradiol treatment




Genotype
MGI:3759417
cx2
Allelic
Composition		 Il2tm1Hor/Il2tm1Hor
Rag2tm1Fwa/Rag2+
Genetic
Background		 involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il2tm1Hor mutation (5 available); any Il2 mutation (32 available)
Rag2tm1Fwa mutation (45 available); any Rag2 mutation (115 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
colitis ( J:29999 )
• occurs in all mice that survive past 9 weeks of age, with thickening of large intestinal wall
enlarged mesenteric lymph nodes ( J:29999 )
• are increased 3-10 fold in size as compared to control littermates

digestive/alimentary system
rectal hemorrhage ( J:29999 )
• is rarely observed
abnormal intestine goblet cell morphology ( J:29999 )
• loss of mucin is observed in goblet cells
diarrhea ( J:29999 )
• occurs in mice by 24 weeks of age
abnormal intestinal epithelium morphology ( J:29999 )
• crypt hyperplasia and unusual branching is observed
rectal prolapse ( J:29999 )
• occasional occurrence among mice whom live past 9 weeks of age
colitis ( J:29999 )
• occurs in all mice that survive past 9 weeks of age, with thickening of large intestinal wall

cardiovascular system
rectal hemorrhage ( J:29999 )
• is rarely observed

growth/size/body
cachexia ( J:29999 )
• weight loss resulting from intestinal inflammation is observed by 24 weeks

hematopoietic system
anemia ( J:29999 )
• occurs in mice 24 weeks of age

behavior/neurological
hunched posture ( J:29999 )
• occurs in mice 24 weeks of age

cellular
abnormal intestine goblet cell morphology ( J:29999 )
• loss of mucin is observed in goblet cells




Genotype
MGI:2665119
cx3
Allelic
Composition		 Rag2tm1Fwa/Rag2+
Trp53tm1Tyj/Trp53tm1Tyj
Genetic
Background		 involves: 129S/SvEv * 129S2/SvPas * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag2tm1Fwa mutation (45 available); any Rag2 mutation (115 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (237 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:47667 )
• survival time at which half of the mutants are sacrificed or die due to illness is 165 days

neoplasm
increased T cell derived lymphoma incidence ( J:47667 )
• thymoma develops in 55% of mutants, a lower frequency than in Trp53 homozygous mice

endocrine/exocrine glands
increased T cell derived lymphoma incidence ( J:47667 )
• thymoma develops in 55% of mutants, a lower frequency than in Trp53 homozygous mice

immune system
increased T cell derived lymphoma incidence ( J:47667 )
• thymoma develops in 55% of mutants, a lower frequency than in Trp53 homozygous mice

hematopoietic system
increased T cell derived lymphoma incidence ( J:47667 )
• thymoma develops in 55% of mutants, a lower frequency than in Trp53 homozygous mice




Genotype
MGI:2665131
cx4
Allelic
Composition		 Rag2tm1Fwa/Rag2+
Tg(LPV-TAg1135)11Tvd/0
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag2tm1Fwa mutation (45 available); any Rag2 mutation (115 available)
Tg(LPV-TAg1135)11Tvd mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:47667 )
• survival time at which half of the mutants are sacrificed or die due to illness is 146 days

neoplasm
increased T cell derived lymphoma incidence ( J:47667 )
• 100% incidence of thymoma

endocrine/exocrine glands
increased T cell derived lymphoma incidence ( J:47667 )
• 100% incidence of thymoma

immune system
increased T cell derived lymphoma incidence ( J:47667 )
• 100% incidence of thymoma

hematopoietic system
increased T cell derived lymphoma incidence ( J:47667 )
• 100% incidence of thymoma




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory