Phenotypes associated with this allele

• Allele Symbol: Smo^bnb
• Allele Name: bent body
• Allele ID: MGI:2137553
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Smo^bnb/Smo^bnb	involves: C3HeB/FeJ * C57BL/6J	MGI:3580659
hm2	Smo^bnb/Smo^bnb	involves: C3H/HeJ * C57BL/6J	MGI:3721246
cx3	Smo^bnb/Smo^bnb Tmem107^schlei/Tmem107^schlei	involves: C3HeB/FeJ * C57BL/6J	MGI:5433093
cx4	Ift172^wim/Ift172^wim Smo^bnb/Smo^bnb	involves: C57BL/6J	MGI:3624270
cx5	Kif7^maki/Kif7^maki Smo^bnb/Smo^bnb Tg(Hlxb9-GFP)1Tmj/?	involves: C57BL/6J * FVB/N	MGI:4355987

Genotype
MGI:3580659

hm1

• Allelic Composition: Smo^bnb/Smo^bnb
• Genetic Background: involves: C3HeB/FeJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:98216 )

• die at E9.0

embryo

abnormal left-right axis patterning ( J:98216 )

• left-right randomization

nervous system

abnormal spinal cord morphology ( J:98216 )

• dorsalized spinal cord

Genotype
MGI:3721246

hm2

• Allelic Composition: Smo^bnb/Smo^bnb
• Genetic Background: involves: C3H/HeJ * C57BL/6J

embryo

abnormal direction of embryo turning ( J:48268 )

• 13 of 25 mice initiate turning in the proper direction (to the right) while 12 of 25 mice start to turn in the opposite direction (to the left)

incomplete embryo turning ( J:48268 )

• at E9.5

decreased embryo size ( J:48268 )

• at E9.5

broad limb buds ( J:48268 )

• at E9.5, limb buds are disproportionally large

cardiovascular system

abnormal heart looping ( J:48268 )

• no clear looping to the left or right is observed

pericardial edema ( J:48268 )

• at E9.5

hemorrhage ( J:48268 )

• at E9.5, mice exhibit hemorrhages in the mesenchyme of the tail, limb buds and head

growth/size/body

decreased embryo size ( J:48268 )

• at E9.5

limbs/digits/tail

broad limb buds ( J:48268 )

• at E9.5, limb buds are disproportionally large

homeostasis/metabolism

pericardial edema ( J:48268 )

• at E9.5

Genotype
MGI:5433093

cx3

• Allelic Composition: Smo^bnb/Smo^bnb; Tmem107^schlei/Tmem107^schlei
• Genetic Background: involves: C3HeB/FeJ * C57BL/6J

nervous system

abnormal floor plate morphology ( J:186552 )

• absence of ventral cell types (V3) in the floor plate

• Background Sensitivity: however, ventral neuron specification defects observed in Smo^bnb homozygotes is partially rescued

exencephaly ( J:186552 )

embryo

abnormal floor plate morphology ( J:186552 )

• absence of ventral cell types (V3) in the floor plate

• Background Sensitivity: however, ventral neuron specification defects observed in Smo^bnb homozygotes is partially rescued

Genotype
MGI:3624270

cx4

• Allelic Composition: Ift172^wim/Ift172^wim; Smo^bnb/Smo^bnb
• Genetic Background: involves: C57BL/6J

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:100466 )

• double mutants survive to E10.5-11.5

cardiovascular system

abnormal direction of heart looping ( J:100466 )

• mutants exhibit randomization of heart looping polarity

nervous system

open neural tube ( J:100466 )

• double mutants have an open neural tube at E10.5

decreased motor neuron number ( J:100466 )

• only a few motor neurons are detected in the spinal cords of mutants

embryo

open neural tube ( J:100466 )

• double mutants have an open neural tube at E10.5

Genotype
MGI:4355987

cx5

• Allelic Composition: Kif7^maki/Kif7^maki; Smo^bnb/Smo^bnb; Tg(Hlxb9-GFP)1Tmj/?
• Genetic Background: involves: C57BL/6J * FVB/N

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:151965 )

• compound mutants develop until E10.5, unlike Smo single mutants that die at or before E9.0

nervous system

nervous system phenotype ( J:151965 )

N • unlike Smo single mutants, compound mutants develop ventral neural types