Analysis Tools|
Allele Symbol Allele Name Allele ID |
Hoxd11+ wild type MGI:2137173 |
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| Summary |
15 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 72% of mice exhibit a reduction in the calcaneus bone compared to in wild-type mice
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• shortened and malformed
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| N |
• male mice are fertile
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• 72% of mice exhibit a reduction in the calcaneus bone compared to in wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• shortened and malformed
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 4 of 7 mice have carpal bone defects
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• 6 of 7 mice have abnormal L4
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• 6 of 7 mice have an L7 formula instead of an L6 formula found in wild
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• 4 of 7 mice have carpal bone defects
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 1 of 11 mice have carpal bone defects
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• 7 of 11 mice have abnormal L4
• 1 of 11 mice have abnormal L6
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• 2 of 11 mice have an L7 formula instead of an L6 formula found in wild-type mice
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• 1 of 11 mice have carpal bone defects
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the proximal carpal bones, navicular lunate and psiform are fused in all mice
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• forearm bones are shorter and broader than in wild-type mice and Hoxa11tm1Mrc homozygotes
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• forearm bones are shorter and broader than in wild-type mice and Hoxa11tm1Mrc homozygotes
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• forearm bones are shorter and broader than in wild-type mice and Hoxa11tm1Mrc homozygotes
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• forearm bones are shorter and broader than in wild-type mice and Hoxa11tm1Mrc homozygotes
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• 7 instead of 6
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• the proximal carpal bones, navicular lunate and psiform are fused in all mice
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• forearm bones are shorter and broader than in wild-type mice and Hoxa11tm1Mrc homozygotes
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• forearm bones are shorter and broader than in wild-type mice and Hoxa11tm1Mrc homozygotes
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• forearm bones are shorter and broader than in wild-type mice and Hoxa11tm1Mrc homozygotes
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• forearm bones are shorter and broader than in wild-type mice and Hoxa11tm1Mrc homozygotes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• show reproductive defects similar to those of mice homozygous for Hoxa11tm1Mrc
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• hypoplasia is more severe than in mice with 4 mutant alleles
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• kidneys, when present, are in a more caudal and ventral location
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• occasionally seen
• more frequent than in mice with 4 mutant alleles
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• at E11.5, the bud forms but frequently migrates away from the metanephric mesenchyme
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• show reproductive defects similar to those of mice homozygous for Hoxa11tm1Mrc
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• show reproductive defects similar to those of mice homozygous for Hoxa11tm1Mrc
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 4 of 10 mice are fertile
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| N |
• mice exhibit a normal number of lumbar vertebrae
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• forearm bones are shorter and broader than in wild-type mice but not as severely affected as in Hoxa11tm1Mrc homozygotes
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• forearm bones are shorter and broader than in wild-type mice but not as severely affected as in Hoxa11tm1Mrc homozygotes
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• forearm bones are shorter and broader than in wild-type mice but not as severely affected as in Hoxa11tm1Mrc homozygotes
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• forearm bones are shorter and broader than in wild-type mice but not as severely affected as in Hoxa11tm1Mrc homozygotes
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• forearm bones are shorter and broader than in wild-type mice but not as severely affected as in Hoxa11tm1Mrc homozygotes
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• forearm bones are shorter and broader than in wild-type mice but not as severely affected as in Hoxa11tm1Mrc homozygotes
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• forearm bones are shorter and broader than in wild-type mice but not as severely affected as in Hoxa11tm1Mrc homozygotes
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• forearm bones are shorter and broader than in wild-type mice but not as severely affected as in Hoxa11tm1Mrc homozygotes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• proximal carpal bones are fused
• one additional mutant allele at either locus leads to carpal malformation as well
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• homeotic transformation of first sacral vertebra to lumbar vertebra 7
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• proximal carpal bones are fused
• one additional mutant allele at either locus leads to carpal malformation as well
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 01/06/2026 MGI 6.24 |
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