growth/size/body
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• normal body weight and size at birth
• peak reduction of body weight around 30 days of age
• body weight returned to normal around 100 days (~3.5 months) of age
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• reduction of growth rate beginning by the first week of age
• growth rate returned to normal by fourth month of age
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behavior/neurological
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• characteristic of generalized seizures displaying upper extremety clonus, rearing and falling
• episodes last ~ 60 seconds with a full recovery
• spikes recorded in the hippocampus and cortex
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• characteristic of focal seizures displaying automatisms of head bobbing and teeth chattering
• mice either recovered from these episodes or the seizures generalized into convulsive seizures
• spikes recorded in the hippocampus
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hearing/vestibular/ear
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• absence of lateral semicircular duct
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homeostasis/metabolism
vision/eye
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• reduction in size
• absence of cilliary process
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mortality/aging
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• 25% lethaltiy, mixed C57BL/6 and DBA/2 F1 background
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nervous system
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• spikes recorded in the hippocampus and cortex
• episodes last ~ 60 seconds with a full recovery
• characteristic of generalized seizures displaying upper extremety clonus, rearing and falling
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• characteristic of focal seizures displaying automatisms of head bobbing and teeth chattering
• mice either recovered from these episodes or the seizures generalized into convulsive seizures
• spikes recorded in the hippocampus
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• normal pituitary cell number, indicating defect in hormone synthesis
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• 80% of mice showed an additional lobule and 15% showed an additional duplication of the rostral end of the declivus
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• 20-25% reduction in weight, with no recovery
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• an additional structure was detected between the superior and inferior colliculi in ~20% of mice
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• reduction in the weight of dorsal telencephalic cortex
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reproductive system
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• absence of advanced differentiating follicles at 30 days of age
• advanced differentiating follicles and corpora lutea were observed by 4 months of age
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• normal histology at 1, 5, and 10 days of age
• no open lumen observed at 20 days of age
• strongly or completely depleted of secondary spermatocytes at 30 days of age
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• maximal reduced size at 30 days of age
• normal size observed at both 10 days and 4 months of age
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• differentiation of spermatocytes ceased until gonadotropic hormone levels were restored
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endocrine/exocrine glands
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• absence of advanced differentiating follicles at 30 days of age
• advanced differentiating follicles and corpora lutea were observed by 4 months of age
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• normal histology at 1, 5, and 10 days of age
• no open lumen observed at 20 days of age
• strongly or completely depleted of secondary spermatocytes at 30 days of age
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• maximal reduced size at 30 days of age
• normal size observed at both 10 days and 4 months of age
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• normal pituitary cell number, indicating defect in hormone synthesis
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