Analysis Tools
normal phenotype
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• mice exhibit no signs of disease and essentially behave as wild-type mice
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Allele Symbol Allele Name Allele ID |
Rb1tm1Brn targeted mutation 1, Anton Berns MGI:1931015 |
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| Summary |
5 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit no signs of disease and essentially behave as wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• all mice die within 20 weeks (or 5 months)
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• at 12 weeks, mice develop pituitary adenomas to which they succumb within 20 weeks of age
• the average latency of tumors is 4 months and all mice die within 5 months
• tumors exhibit hyperproliferation and apoptosis is reduced in end-stage tumors
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• at 12 weeks, mice develop pituitary adenomas to which they succumb within 20 weeks of age
• the average latency of tumors is 4 months and all mice die within 5 months
• tumors exhibit hyperproliferation and apoptosis is reduced in end-stage tumors
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• at 12 weeks, mice develop pituitary adenomas to which they succumb within 20 weeks of age
• the average latency of tumors is 4 months and all mice die within 5 months
• tumors exhibit hyperproliferation and apoptosis is reduced in end-stage tumors
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at 6 and 12 weeks, mice exhibit atypical lesions in the intermediate lobe of the pituitary gland unlike in Rb1tm1Brn homozygotes
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• mice develop pituitary adenomas with an average latency of 9 months
• tumors exhibit hyperproliferation
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• mice develop pituitary adenomas with an average latency of 9 months
• tumors exhibit hyperproliferation
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• at 6 and 12 weeks, mice exhibit atypical lesions in the intermediate lobe of the pituitary gland unlike in Rb1tm1Brn homozygotes
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• mice develop pituitary adenomas with an average latency of 9 months
• tumors exhibit hyperproliferation
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice die of tumors within 11 months
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• at 6 and 12 weeks, mice exhibit extensive hyperplasia with areas of more densely packed cells with nodular appearance unlike in wild-type mice
• at 12 weeks, the cell mass of the intermediate lobe is increased with a 2.5-fold higher cell density of hyperplastic areas and nodules compared to in wild-type mice
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• mice develop pituitary adenomas at a slower rate than in Rb1tm1Brn/ Rb1tm1Brn Tg(Pomc-Flp)1aBrn mice with an average latency of 7 months
• tumors exhibit hyperproliferation
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• mice develop pituitary adenomas at a slower rate than in Rb1tm1Brn/ Rb1tm1Brn Tg(Pomc-Flp)1aBrn mice with an average latency of 7 months
• tumors exhibit hyperproliferation
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• at 6 and 12 weeks, mice exhibit extensive hyperplasia with areas of more densely packed cells with nodular appearance unlike in wild-type mice
• at 12 weeks, the cell mass of the intermediate lobe is increased with a 2.5-fold higher cell density of hyperplastic areas and nodules compared to in wild-type mice
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• mice develop pituitary adenomas at a slower rate than in Rb1tm1Brn/ Rb1tm1Brn Tg(Pomc-Flp)1aBrn mice with an average latency of 7 months
• tumors exhibit hyperproliferation
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at 12 weeks in some mice
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• at 12 weeks in some mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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