All Phenotypes Bdnf<tm1Lfr> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bdnf^tm1Lfr/Bdnf^tm1Lfr	involves: 129S2/SvPas	MGI:3584385
hm2	Bdnf^tm1Lfr/Bdnf^tm1Lfr	involves: 129S2/SvPas * C57BL/6	MGI:2175721
ht3	Bdnf^tm1Lfr/Bdnf⁺	involves: 129S2/SvPas * C57BL/6J	MGI:3584259
cn4	Bdnf^tm1Krj/Bdnf^tm1Lfr H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺	involves: 129S2/SvPas * C57BL/6 * CBA	MGI:3584263
cn5	Bdnf^tm1Krj/Bdnf^tm1Lfr Emx1^tm1(cre)Krj/Emx1⁺	involves: 129S2/SvPas * C57BL/6J	MGI:3584256

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

abnormal circumvallate papillae morphology ( J:55127 )

• the circumvallate papilla is reduced by 39% compared to wild-type littermates and lack morphological integrity

abnormal fungiform papillae morphology ( J:55127 )

• a 57% reduction in the number of fungiform papillae is seen with the remaining papillae concentrated on the anterior-most portion of the tongue

• papillae width is reduced by 33% and the size of the taste buds reduced by 18%

abnormal gustatory papilla taste bud morphology ( J:55127 )

• the number of circumvallate taste buds is reduced by about 73% compared to wild-type littermates

• the size of taste buds on the tips of fungiform papillae is reduced by 18%

short tongue ( J:55127 )

• tongue length averages 8.6 mm compared to 10.3 mm in wild-type littermates

taste/olfaction

abnormal gustatory papilla taste bud morphology ( J:55127 )

• the number of circumvallate taste buds is reduced by about 73% compared to wild-type littermates

• the size of taste buds on the tips of fungiform papillae is reduced by 18%

growth/size/body

abnormal circumvallate papillae morphology ( J:55127 )

• the circumvallate papilla is reduced by 39% compared to wild-type littermates and lack morphological integrity

abnormal fungiform papillae morphology ( J:55127 )

• a 57% reduction in the number of fungiform papillae is seen with the remaining papillae concentrated on the anterior-most portion of the tongue

• papillae width is reduced by 33% and the size of the taste buds reduced by 18%

abnormal gustatory papilla taste bud morphology ( J:55127 )

• the number of circumvallate taste buds is reduced by about 73% compared to wild-type littermates

• the size of taste buds on the tips of fungiform papillae is reduced by 18%

short tongue ( J:55127 )

• tongue length averages 8.6 mm compared to 10.3 mm in wild-type littermates

shortened head ( J:55127 )

• head length averages 13.7 mm compared to 16.1 mm in wild-type littermates

decreased body size ( J:55127 )

craniofacial

abnormal circumvallate papillae morphology ( J:55127 )

• the circumvallate papilla is reduced by 39% compared to wild-type littermates and lack morphological integrity

abnormal fungiform papillae morphology ( J:55127 )

• a 57% reduction in the number of fungiform papillae is seen with the remaining papillae concentrated on the anterior-most portion of the tongue

• papillae width is reduced by 33% and the size of the taste buds reduced by 18%

abnormal gustatory papilla taste bud morphology ( J:55127 )

• the number of circumvallate taste buds is reduced by about 73% compared to wild-type littermates

• the size of taste buds on the tips of fungiform papillae is reduced by 18%

short tongue ( J:55127 )

• tongue length averages 8.6 mm compared to 10.3 mm in wild-type littermates

shortened head ( J:55127 )

• head length averages 13.7 mm compared to 16.1 mm in wild-type littermates

Allelic Composition	Bdnf^tm1Lfr/Bdnf^tm1Lfr
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnf^tm1Lfr mutation (1 available); any Bdnf mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:67231 )

• most die within 48 hours of birth with a few surviving up to 25 days of age

nervous system

abnormal neuron differentiation ( J:67231 )

• reduction in neuropeptide and calcium-binding protein expression in specific regions of the brain (cerebral cortex and hippocampus) suggests impaired neuronal differentiation

abnormal cerebellum external granule cell layer morphology ( J:67231 )

• an external granule cell layer is present at postnatal day (P) 17 but not at P21 indicating delayed granule cell migration

small mesencephalic trigeminal nucleus ( J:67231 )

abnormal cranial ganglia morphology ( J:67231 )

small petrosal ganglion ( J:67231 )

abnormal vestibular ganglion morphology ( J:67231 )

• the size of the vestibular ganglion is reduced

abnormal somatic sensory system morphology ( J:67231 )

decreased sensory neuron number ( J:67231 )

• sensory neuron number is reduced in the trigeminal ganglion, petrosal-nodose ganglion, mesencephalic trigeminal nucleus, and L4 dorsal root ganglion by 27%, 43%, 39%, and 34%, respectively; however motor neuron numbers appear normal

abnormal sensory ganglion morphology ( J:67231 )

• virtually all sensory ganglia have deficits in size or cell number

small geniculate ganglion ( J:67231 )

small nodose ganglion ( J:67231 )

small dorsal root ganglion ( J:67231 )

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:67231 )

• progressively more severe motor defects develop with age

impaired righting response ( J:67231 )

ataxia ( J:67231 )

hunched posture ( J:67231 )

abnormal locomotor activation ( J:67231 )

• homozygotes that survive more than 48 hours display periods of hyperactivity followed by inactivity

spinning ( J:67231 )

respiratory system

decreased pulmonary respiratory rate ( J:67231 )

• reduced and irregular breathing develops with age

cellular

abnormal neuron differentiation ( J:67231 )

• reduction in neuropeptide and calcium-binding protein expression in specific regions of the brain (cerebral cortex and hippocampus) suggests impaired neuronal differentiation

Allelic Composition	Bdnf^tm1Lfr/Bdnf⁺
Genetic Background	involves: 129S2/SvPas * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnf^tm1Lfr mutation (1 available); any Bdnf mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

obese ( J:84683 )

• an 85% increase in body mass is seen at 8 weeks of age

Allelic Composition	Bdnf^tm1Krj/Bdnf^tm1Lfr H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
Genetic Background	involves: 129S2/SvPas * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnf^tm1Krj mutation (1 available); any Bdnf mutation (41 available)
Bdnf^tm1Lfr mutation (1 available); any Bdnf mutation (41 available)
H2az2^{Tg(Wnt1-cre)11Rth} mutation (2 available); any H2az2 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

limb grasping ( J:99291 )

• at 1 month of age 78% of mutants clutch compared to 8% of wild-type mice and by 6 months all mutants clutch compared to 16% of wild-type

impaired coordination ( J:99291 )

• at 4 - 5 weeks of age performance on the rotarod test is impaired

nervous system

abnormal substantia nigra morphology ( J:99291 )

• tyrosine hydroxylase-positive neurons are reduced by about 27% and 23% at postnatal day 0 and 120, respectively and appear disorganized

abnormal substantia nigra pars compacta morphology ( J:99291 )

• the extent of the substantia nigra pars compacta appears reduced in coronal sections but the density of calbindin-positive neurons appears increased

Allelic Composition	Bdnf^tm1Krj/Bdnf^tm1Lfr Emx1^tm1(cre)Krj/Emx1⁺
Genetic Background	involves: 129S2/SvPas * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnf^tm1Krj mutation (1 available); any Bdnf mutation (41 available)
Bdnf^tm1Lfr mutation (1 available); any Bdnf mutation (41 available)
Emx1^tm1(cre)Krj mutation (2 available); any Emx1 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:84683 )

nervous system

abnormal medium spiny neuron morphology ( J:96903 )

• the cross-sectional area of medium spiny neuron soma is reduced by 25% and the diameter of all portions of the dendritic tree is reduced by about 40% compared to wild-type mice with spine density reduced by 30-40% at every order of dendrite

decreased striatum size ( J:96903 )

• the striatal volume is reduced by 15% at P14 and by 33% and P35 and P120

abnormal hippocampus morphology ( J:96903 )

• hippocampal volume is reduced by 12% at 14 days of age however by 120 days of age no significant reduction in hippocampal volume is seen

abnormal cerebral cortex morphology ( J:96903 )

• cortical volume is reduced by 16% at P14, by about 25% at P35, and by 30% at P120

abnormal visual cortex morphology ( J:84683 )

• in layer II/III of the visual cortex soma area is normal at 2 weeks of age but reduced by 28% and 29% at 3 and 5 weeks of age, respectively; however the number of neurons is not significantly different compared to wild-type mice

• in layer II/III of the visual cortex basal dendrite branching is normal at 2 weeks of age, but reduced by 29% at 5 weeks of age with distal branches more severely affected than proximal branches

• in layer II/III of the visual cortex the number of primary dendrites is normal at 2 weeks of age but reduced by 19% and 36% at 3 and 5 weeks of age, respectively, compared to wild-type mice

thin cerebral cortex ( J:84683 )

• at 5 weeks of age the thickness of the somatosensory and visual cortex are reduced by 12% and 17%, respectively and a 22% increase in neuron density is seen in layer II/III of the visual cortex compared to wild-type mice

behavior/neurological

increased aggression ( J:84683 )

limb grasping ( J:96903 )

• all mutants display limb clasping by 120 days of age and clasping progresses with age from only hindlimbs to include hind and forlimbs; however no impairment od motor function is seen in the rotarod test

abnormal nest building behavior ( J:84683 )

growth/size/body

decreased body weight ( J:84683 )

• body weight is reduced at 3 and 5 weeks of age

obese ( J:84683 )

• a 35% increase in body mass is seen at 16 weeks of age

reproductive system

reduced fertility ( J:84683 )

vision/eye

delayed eyelid opening ( J:84683 )

• mutants open their eyes 1 day later

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