All Phenotypes Erbb2<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Erbb2⁺
wild type
MGI:1929625

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Erbb2^tm1Cbm/Erbb2⁺	involves: 129P2/OlaHsd	MGI:3530783
ht2	Erbb2^{tm8.1(Erbb2)Mul}/Erbb2⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:3805581
cn3	Erbb2^{tm8(Erbb2)Mul}/Erbb2⁺ Pten^tm1Hwu/Pten^tm1Hwu Tg(MMTV-cre)7Mul/0	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N	MGI:4839510
cn4	Erbb2^{tm8(Erbb2)Mul}/Erbb2⁺ Pten^tm1Hwu/Pten⁺ Tg(MMTV-cre)7Mul/0	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N	MGI:4839508
cn5	Erbb2^{tm8(Erbb2)Mul}/Erbb2⁺ Tg(MMTV-cre)7Mul/?	involves: 129S1/Sv * 129X1/SvJ * FVB/N	MGI:3714371
cx6	Erbb2^tm1Cbm/Erbb2⁺ Erbb3^tm2Cbm/Erbb3⁺ Nrg1^tm1Cbm/Nrg1⁺	involves: 129P2/OlaHsd	MGI:3530779
cx7	Erbb2^tm1Cbm/Erbb2⁺ Nrg1^tm1Cbm/Nrg1⁺	involves: 129P2/OlaHsd	MGI:3530776

Allelic Composition	Erbb2^tm1Cbm/Erbb2⁺
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb2^tm1Cbm mutation (0 available); any Erbb2 mutation (57 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:90038 )

N	• no decrease in myelin thickness was observed on the sciatic nerve

Allelic Composition	Erbb2^{tm8.1(Erbb2)Mul}/Erbb2⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb2^{tm8.1(Erbb2)Mul} mutation (0 available); any Erbb2 mutation (57 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:89255 )

N	• mammary gland morphology is indistinguishable from wild-type

nervous system

nervous system phenotype ( J:89255 )

N	• appears to develop normally

Allelic Composition	Erbb2^{tm8(Erbb2)Mul}/Erbb2⁺ Pten^tm1Hwu/Pten^tm1Hwu Tg(MMTV-cre)7Mul/0
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb2^{tm8(Erbb2)Mul} mutation (0 available); any Erbb2 mutation (57 available)
Pten^tm1Hwu mutation (17 available); any Pten mutation (86 available)
Tg(MMTV-cre)7Mul mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:133305 )

• mammary tumor onset is accelerated in virgin females compared with either single Pten or single Erbb2 mutants, with tumor latencies of 2.4 compared with 15.5 months

• 25% of tumors are adenomyoepitheliomas

• 25% of tumors are Erbb2 type neoplasms

• 25% of tumors exhibit squamous metaplasia and retention of myoepithelium

• 25% of tumors are glandular, composed of distinctive large cell population that are a signature phenotype of mammary tumors in these mice

• tumors are similar to HER2 and basal-like subtype of human breast cancer

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:133305 )

• mammary tumor onset is accelerated in virgin females compared with either single Pten or single Erbb2 mutants, with tumor latencies of 2.4 compared with 15.5 months

• 25% of tumors are adenomyoepitheliomas

• 25% of tumors are Erbb2 type neoplasms

• 25% of tumors exhibit squamous metaplasia and retention of myoepithelium

• 25% of tumors are glandular, composed of distinctive large cell population that are a signature phenotype of mammary tumors in these mice

• tumors are similar to HER2 and basal-like subtype of human breast cancer

integument

increased mammary gland tumor incidence ( J:133305 )

• mammary tumor onset is accelerated in virgin females compared with either single Pten or single Erbb2 mutants, with tumor latencies of 2.4 compared with 15.5 months

• 25% of tumors are adenomyoepitheliomas

• 25% of tumors are Erbb2 type neoplasms

• 25% of tumors exhibit squamous metaplasia and retention of myoepithelium

• 25% of tumors are glandular, composed of distinctive large cell population that are a signature phenotype of mammary tumors in these mice

• tumors are similar to HER2 and basal-like subtype of human breast cancer

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:133305

Allelic Composition	Erbb2^{tm8(Erbb2)Mul}/Erbb2⁺ Pten^tm1Hwu/Pten⁺ Tg(MMTV-cre)7Mul/0
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:133305 )

• mammary tumor onset is accelerated in virgin females compared with either single Pten or single Erbb2 mutants, with tumor latencies of 6.5 compared with 15.3 months

• tumor progression is associated with loss of heterozygosity at the Pten locus in 50% of mutant mammary tumors

• tumors are similar to basal-like subtype of human breast cancer

increased metastatic potential ( J:133305 )

• 35% incidence of lung metastases compared with 5% in single Erbb2 mutants

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:133305 )

• mammary tumor onset is accelerated in virgin females compared with either single Pten or single Erbb2 mutants, with tumor latencies of 6.5 compared with 15.3 months

• tumor progression is associated with loss of heterozygosity at the Pten locus in 50% of mutant mammary tumors

• tumors are similar to basal-like subtype of human breast cancer

integument

increased mammary gland tumor incidence ( J:133305 )

• mammary tumor onset is accelerated in virgin females compared with either single Pten or single Erbb2 mutants, with tumor latencies of 6.5 compared with 15.3 months

• tumor progression is associated with loss of heterozygosity at the Pten locus in 50% of mutant mammary tumors

• tumors are similar to basal-like subtype of human breast cancer

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:133305

Allelic Composition	Erbb2^{tm8(Erbb2)Mul}/Erbb2⁺ Tg(MMTV-cre)7Mul/?
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb2^{tm8(Erbb2)Mul} mutation (0 available); any Erbb2 mutation (57 available)
Tg(MMTV-cre)7Mul mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal mammary gland development ( J:61202 )

• numerous lobular side buds with acinar structures are observed

abnormal mammary gland lobule morphology ( J:89255 )

• mice develop precocious lobualveolar hyperplasias of the mammary glands

increased mammary gland tumor incidence ( J:89255 )

• virgin female mutants develop mammary tumors with an average latency of 15.9 months with >90% affected by 2 years of age

neoplasm

increased mammary gland tumor incidence ( J:89255 )

• virgin female mutants develop mammary tumors with an average latency of 15.9 months with >90% affected by 2 years of age

integument

abnormal mammary gland development ( J:61202 )

• numerous lobular side buds with acinar structures are observed

abnormal mammary gland lobule morphology ( J:89255 )

• mice develop precocious lobualveolar hyperplasias of the mammary glands

increased mammary gland tumor incidence ( J:89255 )

• virgin female mutants develop mammary tumors with an average latency of 15.9 months with >90% affected by 2 years of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:167180

Allelic Composition	Erbb2^tm1Cbm/Erbb2⁺ Erbb3^tm2Cbm/Erbb3⁺ Nrg1^tm1Cbm/Nrg1⁺
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb2^tm1Cbm mutation (0 available); any Erbb2 mutation (57 available)
Erbb3^tm2Cbm mutation (0 available); any Erbb3 mutation (44 available)
Nrg1^tm1Cbm mutation (0 available); any Nrg1 mutation (56 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal myelination ( J:90038 )

• hypomyelination; thin myelin sheath of sciatic nerve observed at P10 and at 6 months of age

abnormal nerve conduction ( J:90038 )

• reduced nerve conduction velocity measured in the sciatic nerve, but with normal current amplitudes and muscle compound action potentials

Allelic Composition	Erbb2^tm1Cbm/Erbb2⁺ Nrg1^tm1Cbm/Nrg1⁺
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb2^tm1Cbm mutation (0 available); any Erbb2 mutation (57 available)
Nrg1^tm1Cbm mutation (0 available); any Nrg1 mutation (56 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal myelination ( J:90038 )

• hypomyelination; thin myelin sheath of sciatic nerve observed at P10 and at 6 months of age

abnormal nerve conduction ( J:90038 )

• reduced nerve conduction velocity measured in the sciatic nerve, but with normal current amplitudes and muscle compound action potentials

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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