Erbb2^{tm8.1(Erbb2)Mul}
Targeted Allele Detail

Summary

• Symbol: Erbb2^{tm8.1(Erbb2)Mul}
• Name: erb-b2 receptor tyrosine kinase 2; targeted mutation 8.1, William J Muller
• MGI ID: MGI:3793285
• Synonyms: Erbb2^NT
• Gene: Erbb2 Location: Chr11:98303310-98328542 bp, + strand Genetic Position: Chr11, 61.75 cM, cytoband D
• Alliance: Erbb2^{tm8.1(Erbb2)Mul} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89255
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion
• Mutation details: Single-cell embryos with one copy of the Erbb2^{tm8(Erbb2)Mul} recombinant allele were microinjected with a plasmid containing Cre recombinase under the control of the chicken actin promoter. The actin promoter is expressed at the two-cell phase in the mouse embryo and results in direct excision of the floxed neo in the germline and places the Erbb2 cDNA insert under the control of the endogenous promoter in all tissues in which it is normally expressed. (J:89255)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Erbb2^{tm8.1(Erbb2)Mul}

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Erbb2 Mutation: 59 strains or lines available

References

• Original: J:89255 Andrechek ER, et al., Germ-line expression of an oncogenic erbB2 allele confers resistance to erbB2-induced mammary tumorigenesis. Proc Natl Acad Sci U S A. 2004 Apr 6;101(14):4984-9
• All: 2 reference(s)