Phenotypes associated with this allele

• Allele Symbol: Erbb2^{tm8.1(Erbb2)Mul}
• Allele Name: targeted mutation 8.1, William J Muller
• Allele ID: MGI:3793285
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Erbb2^tm8.1(Erbb2)Mul/Erbb2^tm8.1(Erbb2)Mul	involves: 129S1/Sv * 129X1/SvJ	MGI:3805580
ht2	Erbb2^tm8.1(Erbb2)Mul/Erbb2^+	involves: 129S1/Sv * 129X1/SvJ	MGI:3805581

Genotype
MGI:3805580

hm1

• Allelic Composition: Erbb2^{tm8.1(Erbb2)Mul}/Erbb2^{tm8.1(Erbb2)Mul}
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:89255 )

• no homozygous embryos are recovered after 12.5 dpc; embryos start to die by 11.5 dpc

cardiovascular system

abnormal myocardial trabeculae morphology ( J:89255 )

• reduction in trabeculation is observed at 12.5 dpc

muscle

abnormal myocardial trabeculae morphology ( J:89255 )

• reduction in trabeculation is observed at 12.5 dpc

nervous system

abnormal paravertebral ganglion morphology ( J:89255 )

• development is abnormal

Genotype
MGI:3805581

ht2

• Allelic Composition: Erbb2^{tm8.1(Erbb2)Mul}/Erbb2⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

reproductive system

reproductive system phenotype ( J:89255 )

N • mammary gland morphology is indistinguishable from wild-type

nervous system

nervous system phenotype ( J:89255 )

N • appears to develop normally