Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrg1tm1Cbm mutation
(0 available);
any
Nrg1 mutation
(53 available)
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nervous system
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• lack neural crest cell precursor cells in the anlage of the primary sympathetic ganglion chain
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cardiovascular system
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• marker analysis indicates that ventricular myocardial differentiation is impaired
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• marker analysis indicates that ventricular myocardial differentiation is impaired
• however, ventricular cell proliferation is normal
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embryo
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• neural crest cells are scarce at positions ventral of the neural tube and lateral of the dorsal aorta and accumulate at dorsal positions
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cellular
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• neural crest cells are scarce at positions ventral of the neural tube and lateral of the dorsal aorta and accumulate at dorsal positions
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muscle
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• marker analysis indicates that ventricular myocardial differentiation is impaired
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrg1tm1Cbm mutation
(0 available);
any
Nrg1 mutation
(53 available)
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mortality/aging
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• all mutant embryos die by E11.5
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cardiovascular system
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• however, atria were morphologically normal
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• at E10.5, the endocardial cusion was not closed, and the mesenchymal cells forming the cusion were reduced in number
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muscle
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• however, atria were morphologically normal
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nervous system
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• generation of radial glia is impaired
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• no identifiable immature oligodendrocytes were observed in spinal cord explant cultures
• addition of recombinant Nrg1 protein to the cultures rescued this phenotype
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• Schwann cell precursors in the trunk appear reduced in number
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• cranial ganglia cells are reduced in number
• distinct ganglia are altered to different extents
• geniculate and vestibular-cochlea ganglia appear unaffected
• loss of neural-crest derived cells in the ganglia are thought to account for the morphological changes
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• projections are disorganized; projections to CNS often absent
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• projections are disorganized
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• the jugular ganglion is described as abnormal
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• cranial nerves are severely altered, whereas other peripheral projections appear normal
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• mandibular projections and axonal connections between trigeminus and hindbrain are lost
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• lost, particularly the dorsal part
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cellular
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• generation of radial glia is impaired
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growth/size/body
Allelic
Composition |
Nrg1tm1Cbm/Nrg1+
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Genetic
Background |
involves: 129P2/OlaHsd |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrg1tm1Cbm mutation
(0 available);
any
Nrg1 mutation
(53 available)
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mortality/aging
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• 15 days after doxorubicin treatment to induce cardiac injury, survival is significantly lower in homozygotes (15%) than wild-type (33%)
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nervous system
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• hypomyelination; thin myelin sheath of sciatic nerve observed at P10 and at 6 months of age
• more pronounced for large caliber axons than small caliber axons
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• reduced nerve conduction velocity measured in the sciatic nerve, but with normal current amplitudes and muscle compound action potentials
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cardiovascular system
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• 4 days after doxorubicin treatment, homozygotes show a significant decrease in heart (29% loss) and left ventricle (27% loss) weight compared to wild-type (15% for heart and 13% for left ventricle)
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• exhibit more severe doxorubicin-induced cardiotoxicity than wild-type, with lower left ventricular systolic pressure and left ventricular midwall fractional shortening
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• doxorubicin-induced cardiac injury causes a higher reduction in left ventricular midwall fractional shortening than in wild-type
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• doxorubicin-induced cardiac injury causes a higher reduction in left ventricular systolic pressure than in wild-type
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growth/size/body
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• 4 days after doxorubicin treatment, homozygotes show an increase in the loss of body weight (27%) compared to wild-type (11%)
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muscle
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• doxorubicin-induced cardiac injury causes a higher reduction in left ventricular midwall fractional shortening than in wild-type
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homeostasis/metabolism
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Isl2tm1Arbr mutation
(1 available);
any
Isl2 mutation
(28 available)
Nrg1tm1Cbm mutation
(0 available);
any
Nrg1 mutation
(53 available)
Nrg1tm3Cbm mutation
(0 available);
any
Nrg1 mutation
(53 available)
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mortality/aging
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• ~90% of mice die at birth, with phenotype similar to Nrg1tm1Cbm homozygous embryos
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nervous system
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• Schwann cells are absent from intramuscular motor axons between E13.5-E16.5
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• motor neurons are defasciculated and disorganized
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• in developing muscle, motor axons largely retract by birth; by E18.5, motor axons and terminals are absent
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• at diaphragm synapses, band of acetylcholine receptors (AChRs) is wider (17.5% of muscle length) than in wild-type muscle (7% of muscle length)
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Isl1tm1(cre)Tmj mutation
(0 available);
any
Isl1 mutation
(33 available)
Nrg1tm1Cbm mutation
(0 available);
any
Nrg1 mutation
(53 available)
Nrg1tm3Cbm mutation
(0 available);
any
Nrg1 mutation
(53 available)
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muscle
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• mutants exhibit a defect in muscle spindle differentiation in the dorsal root ganglion and motor neurons
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nervous system
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• mutants exhibit a defect in muscle spindle differentiation in the dorsal root ganglion and motor neurons
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• selective absence of Schwann cells at E16.5 in adductor and gracilis muscles but not in other muscles
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• parvalbumin+ proprioceptive afferents are present in E16.5 hindlimb muscles and initiate contact with individual myofibers, but they do not develop annulospiral branches around the myofibers
• parvalbumin+ proprioceptive terminals at muscle spindles remain primitive and unbranched at E18.5
• however, survival and initial differentiation of proprioceptive afferent sensory neurons is not impaired
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb2tm1Cbm mutation
(0 available);
any
Erbb2 mutation
(59 available)
Erbb3tm2Cbm mutation
(0 available);
any
Erbb3 mutation
(47 available)
Nrg1tm1Cbm mutation
(0 available);
any
Nrg1 mutation
(53 available)
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nervous system
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• hypomyelination; thin myelin sheath of sciatic nerve observed at P10 and at 6 months of age
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• reduced nerve conduction velocity measured in the sciatic nerve, but with normal current amplitudes and muscle compound action potentials
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb2tm1Cbm mutation
(0 available);
any
Erbb2 mutation
(59 available)
Nrg1tm1Cbm mutation
(0 available);
any
Nrg1 mutation
(53 available)
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nervous system
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• hypomyelination; thin myelin sheath of sciatic nerve observed at P10 and at 6 months of age
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• reduced nerve conduction velocity measured in the sciatic nerve, but with normal current amplitudes and muscle compound action potentials
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Analysis Tools