Phenotypes associated with this allele

• Allele Symbol: Hoxa13⁺
• Allele Name: wild type
• Allele ID: MGI:1927836
• Summary: 15 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Hoxa13^Hd/Hoxa13^+	B6C3Fe-a/a Hoxa13^Hd Mcoln3^Va-J/J	MGI:3587031
ht2	Hoxa13^tm2Ipc/Hoxa13^+	either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)	MGI:3721891
ht3	Hoxa13^tm1Ipc/Hoxa13^+	either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)	MGI:3721890
ht4	Hoxa13^tm1.1Mrc/Hoxa13^+	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6	MGI:3846357
ht5	Hoxa13^tm1Mrc/Hoxa13^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3846358
ht6	Hoxa13^tm1Jwi/Hoxa13^+	involves: 129S7/SvEvBrd	MGI:3521748
ht7	Hoxa13^Hd/Hoxa13^+	involves: MYA/Hu	MGI:3587027
cn8	Gli3^tm1.1Zllr/Gli3^tm1.2Zllr Hoxa13^tm1.1(cre)Makm/Hoxa13^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:5425261
cx9	Hoxa13^tm1Ipc/Hoxa13^+ Hoxd13^tm1Ddu/Hoxd13^+	either: (involves: 129/Sv * 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)	MGI:3721892
cx10	Hoxa13^tm2Ipc/Hoxa13^+ Hoxd13^tm1Ddu/Hoxd13^+	either: (involves: 129/Sv * 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)	MGI:3721893
cx11	Hoxa13^tm1Ipc/Hoxa13^+ Hoxd13^tm1Ddu/Hoxd13^tm1Ddu	either: (involves: 129/Sv * 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)	MGI:3721895
cx12	Hoxa13^tm2Ipc/Hoxa13^+ Hoxd13^tm1Ddu/Hoxd13^tm1Ddu	either: (involves: 129/Sv * 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)	MGI:3721896
cx13	Hoxa13^tm1Ipc/Hoxa13^+ Hoxd13^spdh/Hoxd13^spdh	involves: 129S2/SvPas * C3HeB/FeJLe * C57BL/6J	MGI:3802672
cx14	Hoxa13^tm1Ipc/Hoxa13^+ Hoxd13^spdh/Hoxd13^+	involves: 129S2/SvPas * C3HeB/FeJLe * C57BL/6J	MGI:3802656
cx15	Hoxa13^Hd/Hoxa13^+ Tg(Prrx1-Sox9,-lacZ)1Haak/0	involves: C57BL/6 * DBA/2 * MYA/Hu	MGI:3840968

Genotype
MGI:3587031

ht1

• Allelic Composition: Hoxa13^Hd/Hoxa13⁺
• Genetic Background: B6C3Fe-a/a Hoxa13^Hd Mcoln3^Va-J/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal ampullary gland morphology ( J:54823 )

♂ • decrease in the number of duct tips in the ampullary gland

abnormal prostate gland anterior lobe morphology ( J:54823 )

♂ • 29% have one lobe of the coagulating gland duct that has a single main duct

small prostate gland dorsolateral lobe ( J:54823 )

♂ • 57% have a smaller dorsal prostate, 43% have a smaller lateral prostate

decreased prostate gland duct number ( J:54823 )

♂ • decrease in the number of duct tips in the dorsal and lateral divisions of the dorsolateral prostate and the ventral prostate

small prostate gland ventral lobe ( J:54823 )

♂ • 43% have a smaller ventral prostate

abnormal seminal vesicle morphology ( J:54823 )

♂ • seminal vesicles have an altered curvature and spiked clefting and lack the secondary and tertiary branches

abnormal branching involved in seminal vesicle morphogenesis ( J:54823 )

♂ • little secondary and tertiary branching is observed

small seminal vesicle ( J:54823 )

♂ • 86% have seminal vesicles that are two thirds the size of wild-type

reproductive system

abnormal ampullary gland morphology ( J:54823 )

♂ • decrease in the number of duct tips in the ampullary gland

abnormal prostate gland anterior lobe morphology ( J:54823 )

♂ • 29% have one lobe of the coagulating gland duct that has a single main duct

small prostate gland dorsolateral lobe ( J:54823 )

♂ • 57% have a smaller dorsal prostate, 43% have a smaller lateral prostate

decreased prostate gland duct number ( J:54823 )

♂ • decrease in the number of duct tips in the dorsal and lateral divisions of the dorsolateral prostate and the ventral prostate

small prostate gland ventral lobe ( J:54823 )

♂ • 43% have a smaller ventral prostate

abnormal seminal vesicle morphology ( J:54823 )

♂ • seminal vesicles have an altered curvature and spiked clefting and lack the secondary and tertiary branches

abnormal branching involved in seminal vesicle morphogenesis ( J:54823 )

♂ • little secondary and tertiary branching is observed

small seminal vesicle ( J:54823 )

♂ • 86% have seminal vesicles that are two thirds the size of wild-type

abnormal uterine cervix morphology ( J:58731 )

♀ • exhibit an anterior transformation of cervical tissue to a uterine stromal phenotype

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hand-foot-genital syndrome		DOID:0060739	OMIM:140000	J:54823

Genotype
MGI:3721891

ht2

• Allelic Composition: Hoxa13^tm2Ipc/Hoxa13⁺
• Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)

limbs/digits/tail

abnormal digit morphology ( J:36214 )

• digit I shows an incomplete segmentation between the two phalangeal cartilages but no truncation

• in digit I of the hindlimb, the terminal phalanx has an altered bell-shaped morphology

abnormal phalanx morphology ( J:36214 )

• digit I shows an incomplete segmentation between the two phalangeal cartilages but no truncation

• in digit I of the hindlimb, the terminal phalanx has an altered bell-shaped morphology

interdigital webbing ( J:36214 )

• some mice have an interdigital fusion in digits II and III

skeleton

abnormal phalanx morphology ( J:36214 )

• digit I shows an incomplete segmentation between the two phalangeal cartilages but no truncation

• in digit I of the hindlimb, the terminal phalanx has an altered bell-shaped morphology

Genotype
MGI:3721890

ht3

• Allelic Composition: Hoxa13^tm1Ipc/Hoxa13⁺
• Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)

limbs/digits/tail

abnormal digit morphology ( J:36214 )

• digit I shows an incomplete segmentation between the two phalangeal cartilages but no truncation

• in digit I of the hindlimb, the terminal phalanx has an altered bell-shaped morphology

abnormal phalanx morphology ( J:36214 )

• digit I shows an incomplete segmentation between the two phalangeal cartilages but no truncation

• in digit I of the hindlimb, the terminal phalanx has an altered bell-shaped morphology

interdigital webbing ( J:36214 )

• some mice have an interdigital fusion in digits II and III

skeleton

abnormal phalanx morphology ( J:36214 )

• digit I shows an incomplete segmentation between the two phalangeal cartilages but no truncation

• in digit I of the hindlimb, the terminal phalanx has an altered bell-shaped morphology

Genotype
MGI:3846357

ht4

• Allelic Composition: Hoxa13^tm1.1Mrc/Hoxa13⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6

limbs/digits/tail

syndactyly ( J:72301 )

• 37% of mice exhibit fusion of soft tissue between hind limb digits II and III unlike in wild-type mice

• at E13.5, apoptosis between digits II and III is reduced compared to in wild-type mice

Genotype
MGI:3846358

ht5

• Allelic Composition: Hoxa13^tm1Mrc/Hoxa13⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

limbs/digits/tail

abnormal limb morphology ( J:72301 )

• authors state that mice show similar phenotypes as observed in Hoxa13^tm1.1Mrc homozygotes

Genotype
MGI:3521748

ht6

• Allelic Composition: Hoxa13^tm1Jwi/Hoxa13⁺
• Genetic Background: involves: 129S7/SvEvBrd

limbs/digits/tail

brachydactyly ( J:94412 )

• shortened first digit in E13.5 forelimb and hindlimb buds and shortened first digit or nail of the hindfoot

syndactyly ( J:94412 )

• occasional cutaneous syndactyly between digits two and three

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hand-foot-genital syndrome		DOID:0060739	OMIM:140000	J:94412

Genotype
MGI:3587027

ht7

• Allelic Composition: Hoxa13^Hd/Hoxa13⁺
• Genetic Background: involves: MYA/Hu

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:5211 )

• a few die before E16

limbs/digits/tail

brachydactyly ( J:64253 , J:5211 )

• varied amount of shortening of the first phalanx of the hallux and forefeet have very short first digits (J:5211)

hindlimb oligodactyly ( J:5211 )

• exhibit loss of the terminal phalanx of the first digit (hallux or great toe) of each hindfoot

absent hallux ( J:121946 )

• on the hindlimb, digit 1 is absent

syndactyly ( J:64253 )

• sometimes exhibit a varied amount of webbing of digits 2, 3, and 4

Genotype
MGI:5425261

cn8

• Allelic Composition: Gli3^tm1.1Zllr/Gli3^tm1.2Zllr; Hoxa13^{tm1.1(cre)Makm}/Hoxa13⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

limbs/digits/tail

polydactyly ( J:184012 )

Genotype
MGI:3721892

cx9

• Allelic Composition: Hoxa13^tm1Ipc/Hoxa13⁺; Hoxd13^tm1Ddu/Hoxd13⁺
• Genetic Background: either: (involves: 129/Sv * 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)

limbs/digits/tail

abnormal carpal bone morphology ( J:36214 )

• in 50% of mice, the fourth posterior distal carpal bone is partly or fully split into two distinct bone

abnormal digit morphology ( J:36214 )

• digits I and V are deformed in the hinblimb

• digit I is more truncated than normal and no first phalanx is visible

• newborn mice show an incomplete segmentation between phalangeal cartilage in digit I

• digit I in the hindlimb has its first phalanx truncated and the terminal phalanx has an altered bell-shaped morphology

• the second phalanges of digits II and mostly in digit V are truncated in the forelimbs and hindlimbs

• digits II and III are fused and alterations in the claw of digit I are observeddigits II and III are fused and alterations in the claw of digit I are observed

abnormal phalanx morphology ( J:36214 )

• digit I lacks a first phalanx and newborn mice show an incomplete segmentation between the two phalangeal cartilages in forelimbs and in some hindlimbs

• digit I in the hindlimb has its first phalanx truncated and the terminal phalanx has an altered bell-shaped morphology

• the second phalanges of digits II and mostly in digit V are truncated in the forelimbs and hindlimbs

brachydactyly ( J:36214 )

• in adults, digits I, II and V are truncated

polydactyly ( J:36214 )

• 23 of 40 mice have an extra posterior digit in the forelimbs consisting of either a small floating bone distal to the post minimus or an entire small digit

interdigital webbing ( J:36214 )

• in adults, digits III and IV are partially fused in the forelimbs and digits II, III and IV are completely fused in the hindlimbs

elongated metatarsal bones ( J:36214 )

• the metatarsal of digit I is elongated

skeleton

abnormal carpal bone morphology ( J:36214 )

• in 50% of mice, the fourth posterior distal carpal bone is partly or fully split into two distinct bone

abnormal phalanx morphology ( J:36214 )

• digit I lacks a first phalanx and newborn mice show an incomplete segmentation between the two phalangeal cartilages in forelimbs and in some hindlimbs

• digit I in the hindlimb has its first phalanx truncated and the terminal phalanx has an altered bell-shaped morphology

• the second phalanges of digits II and mostly in digit V are truncated in the forelimbs and hindlimbs

elongated metatarsal bones ( J:36214 )

• the metatarsal of digit I is elongated

Genotype
MGI:3721893

cx10

• Allelic Composition: Hoxa13^tm2Ipc/Hoxa13⁺; Hoxd13^tm1Ddu/Hoxd13⁺
• Genetic Background: either: (involves: 129/Sv * 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)

limbs/digits/tail

abnormal carpal bone morphology ( J:36214 )

• in 50% of mice, the fourth posterior distal carpal bone is partly or fully split into two distinct bone

abnormal digit morphology ( J:36214 )

• digits I and V are deformed in the hinblimb

• digit I is more truncated than normal and no first phalanx is visible

• digit I in the hindlimb has its first phalanx truncated and the terminal phalanx has an altered bell-shaped morphology

• the second phalanges of digits II and mostly in digit V are truncated in the forelimbs and hindlimbs

• digits II and III are fused and alterations in the claw of digit I are observeddigits II and III are fused and alterations in the claw of digit I are observed

• newborn mice show an incomplete segmentation between phalangeal cartilage in digit I

abnormal phalanx morphology ( J:36214 )

• digit I lacks a first phalanx and newborn mice show an incomplete segmentation between the two phalangeal cartilages in forelimbs and in some hindlimbs

• digit I in the hindlimb has its first phalanx truncated and the terminal phalanx has an altered bell-shaped morphology

• the second phalanges of digits II and mostly in digit V are truncated in the forelimbs and hindlimbs

brachydactyly ( J:36214 )

• in adults, digits I, II and V are truncated

polydactyly ( J:36214 )

• 23 of 40 mice have an extra posterior digit in the forelimbs consisting of either a small floating bone distal to the post minimus or an entire small digit

interdigital webbing ( J:36214 )

• in adults, digits III and IV are partially fused in the forelimbs and digits II, III and IV are completely fused in the hindlimbs

elongated metatarsal bones ( J:36214 )

• the metatarsal of digit I is elongated

skeleton

abnormal carpal bone morphology ( J:36214 )

• in 50% of mice, the fourth posterior distal carpal bone is partly or fully split into two distinct bone

abnormal phalanx morphology ( J:36214 )

• digit I lacks a first phalanx and newborn mice show an incomplete segmentation between the two phalangeal cartilages in forelimbs and in some hindlimbs

• digit I in the hindlimb has its first phalanx truncated and the terminal phalanx has an altered bell-shaped morphology

• the second phalanges of digits II and mostly in digit V are truncated in the forelimbs and hindlimbs

elongated metatarsal bones ( J:36214 )

• the metatarsal of digit I is elongated

Genotype
MGI:3721895

cx11

• Allelic Composition: Hoxa13^tm1Ipc/Hoxa13⁺; Hoxd13^tm1Ddu/Hoxd13^tm1Ddu
• Genetic Background: either: (involves: 129/Sv * 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)

limbs/digits/tail

abnormal autopod morphology ( J:36214 )

• digits of the forelimb autopods consists of short metacarpal/phalangeal bones fused together and terminal phalangeal-like structures are fused to form a common terminal arch

decreased autopod size ( J:36214 )

• the forelimb autopod is drastically truncated

abnormal carpal bone morphology ( J:36214 )

• at one week of age, the cartilage has abnormally large central blastema and extra distal cartilage related to the presence of extra digits

fused carpal bones ( J:36214 )

• the distal carpals are fused

abnormal digit morphology ( J:36214 )

• terminal phalanges are partly fused in digits II through V in the hindlimbs

• at E18.5, forelimbs show selective truncation and delay in the ossification of digits II and V and a rudimentary posterior extra digit cartilage

abnormal phalanx morphology ( J:36214 )

• no individual metatarsal and phalangeal bones are observed in the hindlimbs

• terminal phalanges are partly fused in digits II through V in the hindlimbs of some mice

• at E18.5, forelimbs lack segmentation between certain metacarpals and first phalangeal cartilage

brachydactyly ( J:36214 )

• digits of the forelimb autopods consists of short metacarpal/phalangeal bones fused together and terminal phalangeal-like structures are fused to form a common terminal arch

monodactyly ( J:36214 )

• no individual digits are observed and the extremities of the forepaws are a continuous ridge

fused tarsal bones ( J:36214 )

• the distal tarsals are fused

abnormal metacarpal bone morphology ( J:36214 )

• no individual metatarsal and phalangeal bones are observed in the hindlimbs

• at E18.5, forelimbs lack segmentation between certain metacarpals and first phalangeal cartilage

abnormal digit development ( J:36214 )

• at E13.5, an extra digit condensation is observed

• at E13.5, a central condensation is fused distally to one of its neighbors

• an abnormal condensation occurs between digit IV and V condensations

• at E14.5, a seventh posterior digit condensation is observed and a third digit condensation is prematurely truncated or joined distally to the second cartilage

• at E18.5, none of the digits become properly separated half of the mice have central digits fused with one or both of its neighbors

• the size of the digit cartilages decreases towards the anterior and posterior margins and the entire forefoot has a symmetrical round shape

• at E18.5, hindlimb digit cartilages are severely truncated and almost not segmented with terminal fusions

• at E18.5, forelimbs have seven non-ossified digits

skeleton

abnormal carpal bone morphology ( J:36214 )

• at one week of age, the cartilage has abnormally large central blastema and extra distal cartilage related to the presence of extra digits

fused carpal bones ( J:36214 )

• the distal carpals are fused

abnormal phalanx morphology ( J:36214 )

• no individual metatarsal and phalangeal bones are observed in the hindlimbs

• terminal phalanges are partly fused in digits II through V in the hindlimbs of some mice

• at E18.5, forelimbs lack segmentation between certain metacarpals and first phalangeal cartilage

fused tarsal bones ( J:36214 )

• the distal tarsals are fused

abnormal metacarpal bone morphology ( J:36214 )

• no individual metatarsal and phalangeal bones are observed in the hindlimbs

• at E18.5, forelimbs lack segmentation between certain metacarpals and first phalangeal cartilage

Genotype
MGI:3721896

cx12

• Allelic Composition: Hoxa13^tm2Ipc/Hoxa13⁺; Hoxd13^tm1Ddu/Hoxd13^tm1Ddu
• Genetic Background: either: (involves: 129/Sv * 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)

limbs/digits/tail

abnormal autopod morphology ( J:36214 )

• digits of the forelimb autopods consists of short metacarpal/phalangeal bones fused together and terminal phalangeal-like structures are fused to form a common terminal arch

decreased autopod size ( J:36214 )

• the forelimb autopod is drastically truncated

abnormal carpal bone morphology ( J:36214 )

• at one week of age, the cartilage has abnormally large central blastema and extra distal cartilage related to the presence of extra digits

fused carpal bones ( J:36214 )

• the distal carpals are fused

abnormal digit morphology ( J:36214 )

• terminal phalanges are partly fused in digits II through V in the hindlimbs

• at E18.5, forelimbs show selective truncation and delay in the ossification of digits II and V and a rudimentary posterior extra digit cartilage

abnormal phalanx morphology ( J:36214 )

• no individual metatarsal and phalangeal bones are observed in the hindlimbs

• terminal phalanges are partly fused in digits II through V in the hindlimbs of some mice

• at E18.5, forelimbs lack segmentation between certain metacarpals and first phalangeal cartilage

brachydactyly ( J:36214 )

• digits of the forelimb autopods consists of short metacarpal/phalangeal bones fused together and terminal phalangeal-like structures are fused to form a common terminal arch

monodactyly ( J:36214 )

• no individual digits are observed and the extremities of the forepaws are a continuous ridge

fused tarsal bones ( J:36214 )

• the distal tarsals are fused

abnormal metacarpal bone morphology ( J:36214 )

• no individual metatarsal and phalangeal bones are observed in the hindlimbs

• at E18.5, forelimbs lack segmentation between certain metacarpals and first phalangeal cartilage

abnormal digit development ( J:36214 )

• at E13.5, an extra digit condensation is observed

• at E13.5, a central condensation is fused distally to one of its neighbors

• an abnormal condensation occurs between digit IV and V condensations

• at E14.5, a seventh posterior digit condensation is observed and a third digit condensation is prematurely truncated or joined distally to the second cartilage

• at E18.5, none of the digits become properly separated half of the mice have central digits fused with one or both of its neighbors

• the size of the digit cartilages decreases towards the anterior and posterior margins and the entire forefoot has a symmetrical round shape

• at E18.5, hindlimb digit cartilages are severely truncated and almost not segmented with terminal fusions

• at E18.5, forelimbs have seven non-ossified digits

skeleton

abnormal carpal bone morphology ( J:36214 )

• at one week of age, the cartilage has abnormally large central blastema and extra distal cartilage related to the presence of extra digits

fused carpal bones ( J:36214 )

• the distal carpals are fused

abnormal phalanx morphology ( J:36214 )

• no individual metatarsal and phalangeal bones are observed in the hindlimbs

• terminal phalanges are partly fused in digits II through V in the hindlimbs of some mice

• at E18.5, forelimbs lack segmentation between certain metacarpals and first phalangeal cartilage

fused tarsal bones ( J:36214 )

• the distal tarsals are fused

abnormal metacarpal bone morphology ( J:36214 )

• no individual metatarsal and phalangeal bones are observed in the hindlimbs

• at E18.5, forelimbs lack segmentation between certain metacarpals and first phalangeal cartilage

Genotype
MGI:3802672

cx13

• Allelic Composition: Hoxa13^tm1Ipc/Hoxa13⁺; Hoxd13^spdh/Hoxd13^spdh
• Genetic Background: involves: 129S2/SvPas * C3HeB/FeJLe * C57BL/6J

limbs/digits/tail

abnormal autopod morphology ( J:71694 )

• completely truncated autopod with barely recognizable very shortened digits that are fused laterally to each other

brachypodia ( J:71694 )

brachyphalangia ( J:71694 )

syndactyly ( J:71694 )

fused phalanges ( J:71694 )

skeleton

brachyphalangia ( J:71694 )

fused phalanges ( J:71694 )

vision/eye

iris stroma hypoplasia ( J:71694 )

Genotype
MGI:3802656

cx14

• Allelic Composition: Hoxa13^tm1Ipc/Hoxa13⁺; Hoxd13^spdh/Hoxd13⁺
• Genetic Background: involves: 129S2/SvPas * C3HeB/FeJLe * C57BL/6J

limbs/digits/tail

ectrodactyly ( J:71694 )

• absence of the second phalanges in digits II and V

Genotype
MGI:3840968

cx15

• Allelic Composition: Hoxa13^Hd/Hoxa13⁺; Tg(Prrx1-Sox9,-lacZ)1Haak/0
• Genetic Background: involves: C57BL/6 * DBA/2 * MYA/Hu

limbs/digits/tail

abnormal hallux morphology ( J:121946 )

• on the hindlimb digit 1 is present but small

abnormal phalanx morphology ( J:121946 )

• the proximal phalanx of hindlimb digit 1 is incomplete

polydactyly ( J:121946 )

• pre and post axial polydactyly

skeleton

abnormal phalanx morphology ( J:121946 )

• the proximal phalanx of hindlimb digit 1 is incomplete