Hoxa13^tm1.1Mrc
Targeted Allele Detail

Summary

• Symbol: Hoxa13^tm1.1Mrc
• Name: homeobox A13; targeted mutation 1.1, Mario R Capecchi
• MGI ID: MGI:2152356
• Synonyms: Hoxa13^GFP
• Gene: Hoxa13 Location: Chr6:52235833-52237865 bp, - strand Genetic Position: Chr6, 25.41 cM
• Alliance: Hoxa13^tm1.1Mrc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:72301
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: GFP was inserted in-frame into exon 2. In this derivative of Hoxa13^tm1Mrc, Cre-mediated recombination in the germline removed an adjacent floxed neomycin resistance cassette. The expression pattern in E10.5-E13.5 embryos of a Hoxa13-GFP fusion protein from this allele recapitulates the published Hoxa13 mRNA expression pattern. (J:72301)

Expression

In Mice Carrying this Mutation:	213 assay results
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxa13 Mutation: 29 strains or lines available

References

• Original: J:72301 Stadler HS, et al., Loss of Eph-receptor expression correlates with loss of cell adhesion and chondrogenic capacity in Hoxa13 mutant limbs. Development. 2001 Nov;128(21):4177-88
• All: 10 reference(s)