Analysis Tools|
Allele Symbol Allele Name Allele ID |
Myf6+ wild type MGI:1913095 |
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| Summary |
10 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 1 in 12 mice develop an rhabdomyosarcoma by day 202
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• 1 in 12 mice develop an rhabdomyosarcoma by day 202
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| alveolar rhabdomyosarcoma | DOID:4051 |
OMIM:268220 |
J:93444 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• 2 in 5 mice develop an rhabdomyosarcoma by day 75 to 91
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• 2 in 5 mice develop an rhabdomyosarcoma by day 75 to 91
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| alveolar rhabdomyosarcoma | DOID:4051 |
OMIM:268220 |
J:93444 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• pups are immobile and die shortly after birth
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• myogenesis appears normal at E12.5
• increasing apoptosis until all differentiating myofibers are either dead or dying at E18.5
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• newborns lack differentiated myofibers
• basophilic clumps of cellular debris suggest skeletal muscle forms and then degenerates
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|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• 1 in 228 mice develop an rhabdomyosarcoma that arises from the pectoralis major muscle by day 383
|
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• 1 in 228 mice develop an rhabdomyosarcoma that arises from the pectoralis major muscle by day 383
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| alveolar rhabdomyosarcoma | DOID:4051 |
OMIM:268220 |
J:93444 | |
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• 4 in 14 mice develop an rhabdomyosarcoma by day 56 to 89
|
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• 4 in 14 mice develop an rhabdomyosarcoma by day 56 to 89
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| alveolar rhabdomyosarcoma | DOID:4051 |
OMIM:268220 |
J:93444 | |
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• double heterozygous mice in which the Myf5 and Myf6 alleles are on different chromosomes show severely reduced expression of Myf5 and die at birth due to respiratory distress
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• sternum shows irregular ossification of sternebrae
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• none of the first seven ribs are attached to the sternum
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• fusion of adjacent ribs
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• short ribs; ribs are shorter than in wild-type or Myf6 homozygotes but longer than the stubs of Myf5 homozygotes
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• myotomes are disorganized at E10.5
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|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• Myod expression is half that seen in wild-type mice
• before E10.5, markers of muscle differentiation are lacking
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|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• double heterozygous mice that carry the Myf5 and Myf6 alleles on different chromosomes and express drastically reduced levels of Myf5 mRNA do not survive to weaning and when delivered by cesarean section at E18.5, the pups die within a few minutes after delivery
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• mutants lack the distal parts of the ribs
• the average rib length is between that of Myf6 and Myf5 homozygotes
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|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• 63% of double heterozygous mice, in which the Myf5 and Myf6 alleles are on different chromosomes and show severely reduced expression of Myf5, die immediately after birth; the rest survive
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• attachment failure of at least one rib to the sternum is seen in most mutants, although the identity of the affected rib(s) and the number of ribs affected varies
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• abnormal ribs
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• number of myocytes in the myotomes is reduced at E10.5 and the conformation of the myotome is abnormal
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 03/18/2025 MGI 6.24 |
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