Phenotypes associated with this allele

• Allele Symbol: Ets2^tm1Rgo
• Allele Name: targeted mutation 1, Robert G Oshima
• Allele ID: MGI:1891557
• Summary: 6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ets2^tm1Rgo/Ets2^tm1Rgo	either: (involves: 129S2/SvPas * 129/Sv) or (involves: 129S2/SvPas * Black Swiss)	MGI:2175869
ht2	Ets2^tm2Rgo/Ets2^tm1Rgo	involves: FVB/N	MGI:2682668
cn3	Ets2^tm1Rgo/Ets2^tm5.1Rgo Pten^tm1.1Mwst/Pten^tm1.1Mwst Tg(S100a4-cre)1Gle/0	involves: 129S2/SvPas * FVB/N	MGI:4366764
cn4	Ets2^tm1Rgo/Ets2^tm5.1Rgo Tg(MMTV-PyVT)634Mul/0 Tg(S100a4-cre)1Gle/0	involves: 129S2/SvPas * FVB/N	MGI:4366767
cn5	Ets2^tm1Rgo/Ets2^tm5.1Rgo Tg(S100a4-cre)1Gle/0	involves: 129S2/SvPas * FVB/N	MGI:4366768
cx6	Ets2^tm1Rgo/Ets2^+ Tg(MMTV-PyVT)634Mul/0	involves: 129S2/SvPas * Black Swiss * FVB/N	MGI:2680919

Genotype
MGI:2175869

hm1

• Allelic Composition: Ets2^tm1Rgo/Ets2^tm1Rgo
• Genetic Background: either: (involves: 129S2/SvPas * 129/Sv) or (involves: 129S2/SvPas * Black Swiss)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between somite formation and embryo turning, complete penetrance ( J:47620 )

• death by E8.5

• rescue of embryos was achieved by aggregation with tetraploid embryos which provided functional extraembryonic tissue

embryo

decreased embryo size ( J:47620 )

abnormal extraembryonic tissue morphology ( J:47620 )

• persistent extracellular matrix

abnormal ectoplacental cone morphology ( J:47620 )

• failure of proliferation

abnormal trophoblast layer morphology ( J:47620 )

abnormal trophoblast giant cell morphology ( J:47620 )

growth/size/body

decreased embryo size ( J:47620 )

integument

increased curvature of auchene hairs ( J:47620 )

• exhibited by rescued mice

increased curvature of awl hairs ( J:47620 )

• exhibited by rescued mice

waved hair ( J:47620 )

• exhibited by rescued mice

increased curvature of guard hairs ( J:47620 )

• exhibited by rescued mice

increased curvature of zigzag hairs ( J:47620 )

• exhibited by rescued mice

abnormal hair follicle orientation ( J:47620 )

• exhibited by rescued mice

curly vibrissae ( J:47620 )

• exhibited by rescued mice

Genotype
MGI:2682668

ht2

• Allelic Composition: Ets2^tm2Rgo/Ets2^tm1Rgo
• Genetic Background: involves: FVB/N

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:86530 )

• death occurs around E11.5

embryo

absent vitelline blood vessels ( J:86530 )

cardiovascular system

absent vitelline blood vessels ( J:86530 )

Genotype
MGI:4366764

cn3

• Allelic Composition: Ets2^tm1Rgo/Ets2^tm5.1Rgo; Pten^tm1.1Mwst/Pten^tm1.1Mwst; Tg(S100a4-cre)1Gle/0
• Genetic Background: involves: 129S2/SvPas * FVB/N

neoplasm

decreased mammary gland tumor incidence ( J:153747 )

• fewer and smaller tumors form in mice injected with the mammary tumor line NT2.5 compared to in similarly treated Pten^tm1.1Mwst/Pten^tm1.1Mwst Tg(S100a4-cre)1Gle mice

increased mammary gland tumor incidence ( J:153747 )

• mice injected with the mammary tumor line NT2.5 develop more mammary tumors than in similarly treated Pten^tm1.1Mwst homozygotes

abnormal tumor morphology ( J:153747 )

• mammary tumors induced by NT2.5 exhibit decreased numbers of macrophages and recruitment of new vasculature compared to in similarly treated Pten^tm1.1Mwst homozygotes

integument

decreased mammary gland tumor incidence ( J:153747 )

• fewer and smaller tumors form in mice injected with the mammary tumor line NT2.5 compared to in similarly treated Pten^tm1.1Mwst/Pten^tm1.1Mwst Tg(S100a4-cre)1Gle mice

increased mammary gland tumor incidence ( J:153747 )

• mice injected with the mammary tumor line NT2.5 develop more mammary tumors than in similarly treated Pten^tm1.1Mwst homozygotes

endocrine/exocrine glands

decreased mammary gland tumor incidence ( J:153747 )

• fewer and smaller tumors form in mice injected with the mammary tumor line NT2.5 compared to in similarly treated Pten^tm1.1Mwst/Pten^tm1.1Mwst Tg(S100a4-cre)1Gle mice

increased mammary gland tumor incidence ( J:153747 )

• mice injected with the mammary tumor line NT2.5 develop more mammary tumors than in similarly treated Pten^tm1.1Mwst homozygotes

Genotype
MGI:4366767

cn4

• Allelic Composition: Ets2^tm1Rgo/Ets2^tm5.1Rgo; Tg(MMTV-PyVT)634Mul/0; Tg(S100a4-cre)1Gle/0
• Genetic Background: involves: 129S2/SvPas * FVB/N

neoplasm

decreased mammary gland tumor incidence ( J:153747 )

• fewer mammary tumors form than in Ets2^tm1Rgo/Ets2^tm5.1Rgo Tg(MMTV-PyVT)634Mul mice and progression to adenoma and early carcinoma is slowed

integument

decreased mammary gland tumor incidence ( J:153747 )

• fewer mammary tumors form than in Ets2^tm1Rgo/Ets2^tm5.1Rgo Tg(MMTV-PyVT)634Mul mice and progression to adenoma and early carcinoma is slowed

endocrine/exocrine glands

decreased mammary gland tumor incidence ( J:153747 )

• fewer mammary tumors form than in Ets2^tm1Rgo/Ets2^tm5.1Rgo Tg(MMTV-PyVT)634Mul mice and progression to adenoma and early carcinoma is slowed

Genotype
MGI:4366768

cn5

• Allelic Composition: Ets2^tm1Rgo/Ets2^tm5.1Rgo; Tg(S100a4-cre)1Gle/0
• Genetic Background: involves: 129S2/SvPas * FVB/N

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:153747 )

N • mice exhibit normal mammary gland development

Genotype
MGI:2680919

cx6

• Allelic Composition: Ets2^tm1Rgo/Ets2⁺; Tg(MMTV-PyVT)634Mul/0
• Genetic Background: involves: 129S2/SvPas * Black Swiss * FVB/N

neoplasm

decreased tumor growth/size ( J:57272 )

• reduced size of mammary tumors relative to controls

• correlated with a more differentiated state of early hyperplastic growths