All Phenotypes Tg(Wnt1)1Hev MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Wnt1)1Hev
transgene insertion 1, Harold E Varmus
MGI:1890080

Summary

14 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Mtdh^Gt(XB780)Byg/Mtdh⁺ Tg(Wnt1)1Hev/0	FVB.Cg-Mtdh^Gt(XB780)Byg Tg(Wnt1)1Hev	MGI:5649042
cx2	Mtdh^Gt(XB780)Byg/Mtdh^Gt(XB780)Byg Tg(Wnt1)1Hev/0	FVB.Cg-Mtdh^Gt(XB780)Byg Tg(Wnt1)1Hev	MGI:5649041
cx3	Esr1^tm1Ksk/Esr1^tm1Ksk Tg(Wnt1)1Hev/0	involves: 129P2/OlaHsd * C57BL/6 * SJL	MGI:4437739
cx4	Id2^tm1Yyk/Id2^tm1Yyk Tg(Wnt1)1Hev/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB * SJL	MGI:3773758
cx5	Id2^tm1Yyk/Id2⁺ Tg(Wnt1)1Hev/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB * SJL	MGI:3773817
cx6	Pten^tm1Rps/Pten⁺ Tg(Wnt1)1Hev/0	involves: 129S1/Sv * C57BL/6 * FVB/N * SJL	MGI:5442747
cx7	Sdc1^tm1Cma/Sdc1⁺ Tg(Wnt1)1Hev/0	involves: 129S4/SvJae * C57BL/6 * SJL	MGI:3521902
cx8	Sdc1^tm1Cma/Sdc1^tm1Cma Tg(Wnt1)1Hev/0	involves: 129S4/SvJae * C57BL/6 * SJL	MGI:3521901
cx9	Muc1^tm1Gend/Muc1^tm1Gend Tg(Wnt1)1Hev/?	involves: FVB	MGI:3574843
cx10	Chek1^tm1Sje/Chek1⁺ Tg(Wnt1)1Hev/0	Not Specified	MGI:3588947
tg11	Tg(Wnt1)1Hev/0	either: FVB/N or (involves: C57BL/6 * SJL)	MGI:2174885
tg12	Tg(Wnt1)1Hev/0	involves: 129P2/OlaHsd * C57BL/6 * SJL	MGI:4437740
tg13	Tg(Wnt1)1Hev/0	involves: C57BL/6 * FVB * SJL	MGI:3773757
tg14	Tg(Wnt1)1Hev/0	involves: C57BL/6 * SJL	MGI:4819121

Allelic Composition	Mtdh^Gt(XB780)Byg/Mtdh⁺ Tg(Wnt1)1Hev/0
Genetic Background	FVB.Cg-Mtdh^Gt(XB780)Byg Tg(Wnt1)1Hev

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mtdh^Gt(XB780)Byg mutation (0 available); any Mtdh mutation (32 available)
Tg(Wnt1)1Hev mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased mammary gland tumor incidence ( J:214244 )

• no tumors are detected in 35% of mice at 300 days of age unlike in transgenic mice wild-type for Mtdh

• the number of tumors in mice with tumors is also reduced compared to transgenic mice wild-type for Mtdh

increased tumor latency ( J:214244 )

• no tumors are detected in 35% of mice at 300 days of age unlike in transgenic mice wild-type for Mtdh

endocrine/exocrine glands

decreased mammary gland tumor incidence ( J:214244 )

• no tumors are detected in 35% of mice at 300 days of age unlike in transgenic mice wild-type for Mtdh

• the number of tumors in mice with tumors is also reduced compared to transgenic mice wild-type for Mtdh

integument

decreased mammary gland tumor incidence ( J:214244 )

• no tumors are detected in 35% of mice at 300 days of age unlike in transgenic mice wild-type for Mtdh

• the number of tumors in mice with tumors is also reduced compared to transgenic mice wild-type for Mtdh

Allelic Composition	Mtdh^Gt(XB780)Byg/Mtdh^Gt(XB780)Byg Tg(Wnt1)1Hev/0
Genetic Background	FVB.Cg-Mtdh^Gt(XB780)Byg Tg(Wnt1)1Hev

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mtdh^Gt(XB780)Byg mutation (0 available); any Mtdh mutation (32 available)
Tg(Wnt1)1Hev mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased mammary gland tumor incidence ( J:214244 )

• no tumors are detected in 62% of mice at 300 days of age unlike in transgenic mice wild-type for Mtdh

• the number of tumors in mice with tumors is also reduced compared to transgenic mice wild-type for Mtdh

increased tumor latency ( J:214244 )

• no tumors are detected in 62% of mice at 300 days of age unlike in transgenic mice wild-type for Mtdh

integument

decreased mammary gland tumor incidence ( J:214244 )

• no tumors are detected in 62% of mice at 300 days of age unlike in transgenic mice wild-type for Mtdh

• the number of tumors in mice with tumors is also reduced compared to transgenic mice wild-type for Mtdh

mammary gland hyperplasia ( J:214244 )

• display fewer and smaller hyperplastic foci at 4 weeks of age compared to transgenic mice wild-type for Mtdh

endocrine/exocrine glands

decreased mammary gland tumor incidence ( J:214244 )

• no tumors are detected in 62% of mice at 300 days of age unlike in transgenic mice wild-type for Mtdh

• the number of tumors in mice with tumors is also reduced compared to transgenic mice wild-type for Mtdh

mammary gland hyperplasia ( J:214244 )

• display fewer and smaller hyperplastic foci at 4 weeks of age compared to transgenic mice wild-type for Mtdh

Allelic Composition	Esr1^tm1Ksk/Esr1^tm1Ksk Tg(Wnt1)1Hev/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Esr1^tm1Ksk mutation (2 available); any Esr1 mutation (67 available)
Tg(Wnt1)1Hev mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:54215 )

• both sexes develop lobuloalveolar adenocarcinomas

increased tumor latency ( J:54215 )

• compared to transgenic mice wild-type for Esr1

endocrine/exocrine glands

abnormal mammary gland development ( J:54215 )

• virgin females display underdeveloped glands at 10 weeks of age with a hyperplastic rudimentary ductal network that lacks terminal end buds

mammary gland duct hyperplasia ( J:54215 )

• in the interior of the gland in virgin females

mammary gland alveolar hyperplasia ( J:54215 )

• in virgin females, regions of lobuloalveolar hyperplasia at the periphery of the gland

increased mammary adenocarcinoma incidence ( J:54215 )

• both sexes develop lobuloalveolar adenocarcinomas

mammary gland hyperplasia ( J:54215 )

• virgin females display underdeveloped glands at 10 weeks of age with a hyperplastic rudimentary ductal network that lacks terminal end buds

• unlike in transgenic mice wild-type for Esr1, hyperplasia does not progress with age in virgin females

• males display epithelial hyperplasia that does not extend into the inguinal fat pad similar to what is seen in females

integument

abnormal mammary gland development ( J:54215 )

• virgin females display underdeveloped glands at 10 weeks of age with a hyperplastic rudimentary ductal network that lacks terminal end buds

mammary gland duct hyperplasia ( J:54215 )

• in the interior of the gland in virgin females

mammary gland alveolar hyperplasia ( J:54215 )

• in virgin females, regions of lobuloalveolar hyperplasia at the periphery of the gland

increased mammary adenocarcinoma incidence ( J:54215 )

• both sexes develop lobuloalveolar adenocarcinomas

mammary gland hyperplasia ( J:54215 )

• virgin females display underdeveloped glands at 10 weeks of age with a hyperplastic rudimentary ductal network that lacks terminal end buds

• unlike in transgenic mice wild-type for Esr1, hyperplasia does not progress with age in virgin females

• males display epithelial hyperplasia that does not extend into the inguinal fat pad similar to what is seen in females

Allelic Composition	Id2^tm1Yyk/Id2^tm1Yyk Tg(Wnt1)1Hev/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Id2^tm1Yyk mutation (0 available); any Id2 mutation (19 available)
Tg(Wnt1)1Hev mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal branching of the mammary ductal tree ( J:96305 )

• mammary glands of virgin females have excessive ductal side branching resembling that of pregnant wild-type mice

increased mammary gland tumor incidence ( J:96305 )

• develop mammary tumors at a similar rate to that seen in single hemizygous Tg(Wnt1)1Hev mice

mammary gland hyperplasia ( J:96305 )

• mammary glands of virgin females have extensive, dense hyperplasia

neoplasm

increased mammary gland tumor incidence ( J:96305 )

• develop mammary tumors at a similar rate to that seen in single hemizygous Tg(Wnt1)1Hev mice

integument

abnormal branching of the mammary ductal tree ( J:96305 )

• mammary glands of virgin females have excessive ductal side branching resembling that of pregnant wild-type mice

increased mammary gland tumor incidence ( J:96305 )

• develop mammary tumors at a similar rate to that seen in single hemizygous Tg(Wnt1)1Hev mice

mammary gland hyperplasia ( J:96305 )

• mammary glands of virgin females have extensive, dense hyperplasia

Allelic Composition	Id2^tm1Yyk/Id2⁺ Tg(Wnt1)1Hev/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Id2^tm1Yyk mutation (0 available); any Id2 mutation (19 available)
Tg(Wnt1)1Hev mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal branching of the mammary ductal tree ( J:96305 )

• mammary glands of virgin females have excessive ductal side branching resembling that of pregnant wild-type mice

increased mammary gland tumor incidence ( J:96305 )

• develop mammary tumors at a similar rate to that seen in single Tg(Wnt1)1Hev mice

mammary gland hyperplasia ( J:96305 )

• mammary glands of virgin females have extensive, dense hyperplasia

neoplasm

increased mammary gland tumor incidence ( J:96305 )

• develop mammary tumors at a similar rate to that seen in single Tg(Wnt1)1Hev mice

integument

abnormal branching of the mammary ductal tree ( J:96305 )

• mammary glands of virgin females have excessive ductal side branching resembling that of pregnant wild-type mice

increased mammary gland tumor incidence ( J:96305 )

• develop mammary tumors at a similar rate to that seen in single Tg(Wnt1)1Hev mice

mammary gland hyperplasia ( J:96305 )

• mammary glands of virgin females have extensive, dense hyperplasia

Allelic Composition	Pten^tm1Rps/Pten⁺ Tg(Wnt1)1Hev/0
Genetic Background	involves: 129S1/Sv * C57BL/6 * FVB/N * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pten^tm1Rps mutation (1 available); any Pten mutation (81 available)
Tg(Wnt1)1Hev mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary gland ductal carcinoma incidence ( J:67497 )

• 50% of females develop mammary ductal carcinoma by 3.5 months of age, earlier than single Tg(Wnt1)1Hev hemizygotes, and all females show tumors by 5 months of age

• 2 of 22 tumors in males are mammary in origin

increased metastatic potential ( J:67497 )

• mutants occasionally show pulmonary metastasis

increased adenocarcinoma incidence ( J:67497 )

• tumors are adenocarcinomas with cribiform, cystic and focal papillary growth patterns

• 50% of males develop tumors by 5.5 months and all males develop tumors within 10 months

• 50% of females develop tumors by 3.5 months of age and all females have tumors within 5 months of age

• 6 of 22 tumors in males are bilateral or unilateral muzzle tumors of epithelial origin

• 7 or 11 tumors show loss of Pten heterozygosity

• most mutants (38 of 49) develop only one palpable tumor

increased salivary adenocarcinoma incidence ( J:67497 )

• 14 of 22 tumors in males arise in the salivary tissue

increased mammary adenocarcinoma incidence ( J:67497 )

endocrine/exocrine glands

increased salivary adenocarcinoma incidence ( J:67497 )

• 14 of 22 tumors in males arise in the salivary tissue

increased mammary adenocarcinoma incidence ( J:67497 )

increased mammary gland ductal carcinoma incidence ( J:67497 )

• 50% of females develop mammary ductal carcinoma by 3.5 months of age, earlier than single Tg(Wnt1)1Hev hemizygotes, and all females show tumors by 5 months of age

• 2 of 22 tumors in males are mammary in origin

integument

increased mammary adenocarcinoma incidence ( J:67497 )

increased mammary gland ductal carcinoma incidence ( J:67497 )

• 50% of females develop mammary ductal carcinoma by 3.5 months of age, earlier than single Tg(Wnt1)1Hev hemizygotes, and all females show tumors by 5 months of age

• 2 of 22 tumors in males are mammary in origin

digestive/alimentary system

increased salivary adenocarcinoma incidence ( J:67497 )

• 14 of 22 tumors in males arise in the salivary tissue

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:67497

Allelic Composition	Sdc1^tm1Cma/Sdc1⁺ Tg(Wnt1)1Hev/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sdc1^tm1Cma mutation (0 available); any Sdc1 mutation (21 available)
Tg(Wnt1)1Hev mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased tumor incidence ( J:63122 )

• 30% of hemizygous females expressing the transgene in a Sdc1^tm1Cma heterozygous null background develop mammary tumors (median time: ~25 weeks) versus 34% of hemizygous females in a Sdc1 wild-type background (median time: ~21 weeks)

• these Wnt1-induced tumors are predominantly alveolar adenocarcinomas

Allelic Composition	Sdc1^tm1Cma/Sdc1^tm1Cma Tg(Wnt1)1Hev/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sdc1^tm1Cma mutation (0 available); any Sdc1 mutation (21 available)
Tg(Wnt1)1Hev mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased tumor incidence ( J:63122 )

• only 3% of hemizygous females expressing the transgene in a Sdc1^tm1Cma null background develop mammary tumors (median time: ~36 weeks) versus 34% of hemizygous females in a Sdc1 wild-type background (median time: ~21 weeks)

• these Wnt1-induced tumors are predominantly alveolar adenocarcinomas

endocrine/exocrine glands

mammary gland hyperplasia ( J:63122 )

• hemizygous females expressing the transgene in a Sdc1^tm1Cma null background exhibit a ~70% inhibition of Wnt1-induced mammary gland hyperplasia relative to hemizygous females of a Sdc1 wild-type background

integument

mammary gland hyperplasia ( J:63122 )

Allelic Composition	Muc1^tm1Gend/Muc1^tm1Gend Tg(Wnt1)1Hev/?
Genetic Background	involves: FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Muc1^tm1Gend mutation (1 available); any Muc1 mutation (37 available)
Tg(Wnt1)1Hev mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased tumor growth/size ( J:82470 )

• onset of mammary tumors was considerably delayed

• tumors were P-type

Allelic Composition	Chek1^tm1Sje/Chek1⁺ Tg(Wnt1)1Hev/0
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chek1^tm1Sje mutation (0 available); any Chek1 mutation (41 available)
Tg(Wnt1)1Hev mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:62919 )

• earlier onset of mammary tumors (168 days versus 219 days of age) than in mice carrying only the transgene

• no differences in gross pathology, histopathology, or growth rates of these tumors compared to those in mice carrying only the transgene and not the Chek1 mutation

integument

increased mammary adenocarcinoma incidence ( J:62919 )

• earlier onset of mammary tumors (168 days versus 219 days of age) than in mice carrying only the transgene

• no differences in gross pathology, histopathology, or growth rates of these tumors compared to those in mice carrying only the transgene and not the Chek1 mutation

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:62919 )

• earlier onset of mammary tumors (168 days versus 219 days of age) than in mice carrying only the transgene

• no differences in gross pathology, histopathology, or growth rates of these tumors compared to those in mice carrying only the transgene and not the Chek1 mutation

Allelic Composition	Tg(Wnt1)1Hev/0
Genetic Background	either: FVB/N or (involves: C57BL/6 * SJL)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Wnt1)1Hev mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal mammary gland morphology ( J:28473 )

• mammary glands in virgin females resemble hormonally-stimulated glands from pregnant mice

abnormal branching of the mammary ductal tree ( J:28473 )

• hemizygous transgenic females show a marked increase in the number of terminal branches

abnormal mammary gland lobule morphology ( J:28473 )

• hemizygous transgenic females display diffuse lobular hyperplasia

mammary gland alveolar hyperplasia ( J:28473 )

integument

abnormal mammary gland morphology ( J:28473 )

• mammary glands in virgin females resemble hormonally-stimulated glands from pregnant mice

abnormal branching of the mammary ductal tree ( J:28473 )

• hemizygous transgenic females show a marked increase in the number of terminal branches

abnormal mammary gland lobule morphology ( J:28473 )

• hemizygous transgenic females display diffuse lobular hyperplasia

mammary gland alveolar hyperplasia ( J:28473 )

Allelic Composition	Tg(Wnt1)1Hev/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Wnt1)1Hev mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:54215 )

• both sexes develop lobuloalveolar adenocarcinomas

• tumor development or progression is not affected by pregnancies or ovariectomy

endocrine/exocrine glands

mammary gland duct hyperplasia ( J:54215 )

• in virgin females

mammary gland alveolar hyperplasia ( J:54215 )

• lobuloalveolar hyperplasia in virgin females

increased mammary adenocarcinoma incidence ( J:54215 )

• both sexes develop lobuloalveolar adenocarcinomas

• tumor development or progression is not affected by pregnancies or ovariectomy

mammary gland hyperplasia ( J:54215 )

• at 10 weeks of age in virgin females

• at 6 months of age in virgin females, hyperplastic epithelium fills the entire inguinal fat pad

• males display epithelial hyperplasia that does not extend into the inguinal fat pad

integument

mammary gland duct hyperplasia ( J:54215 )

• in virgin females

mammary gland alveolar hyperplasia ( J:54215 )

• lobuloalveolar hyperplasia in virgin females

increased mammary adenocarcinoma incidence ( J:54215 )

• both sexes develop lobuloalveolar adenocarcinomas

• tumor development or progression is not affected by pregnancies or ovariectomy

mammary gland hyperplasia ( J:54215 )

• at 10 weeks of age in virgin females

• at 6 months of age in virgin females, hyperplastic epithelium fills the entire inguinal fat pad

• males display epithelial hyperplasia that does not extend into the inguinal fat pad

Allelic Composition	Tg(Wnt1)1Hev/0
Genetic Background	involves: C57BL/6 * FVB * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Wnt1)1Hev mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal branching of the mammary ductal tree ( J:96305 )

• mammary glands of virgin females have excessive ductal side branching resembling that of pregnant wild-type mice

increased mammary gland tumor incidence ( J:96305 )

• develop mammary tumors

mammary gland hyperplasia ( J:96305 )

• mammary glands of virgin females have extensive, dense hyperplasia

neoplasm

increased mammary gland tumor incidence ( J:96305 )

• develop mammary tumors

integument

abnormal branching of the mammary ductal tree ( J:96305 )

• mammary glands of virgin females have excessive ductal side branching resembling that of pregnant wild-type mice

increased mammary gland tumor incidence ( J:96305 )

• develop mammary tumors

mammary gland hyperplasia ( J:96305 )

• mammary glands of virgin females have extensive, dense hyperplasia

Allelic Composition	Tg(Wnt1)1Hev/0
Genetic Background	involves: C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Wnt1)1Hev mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:61009 )

• at 18 weeks

endocrine/exocrine glands

mammary gland duct hyperplasia ( J:61009 )

• at 18 weeks

increased mammary adenocarcinoma incidence ( J:61009 )

• at 18 weeks

integument

mammary gland duct hyperplasia ( J:61009 )

• at 18 weeks

increased mammary adenocarcinoma incidence ( J:61009 )

• at 18 weeks

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:61009

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