Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il4ratm1Sz mutation
(2 available);
any
Il4ra mutation
(41 available)
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immune system
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• mice make increased levels of IgG2 in response to N. brasiliensis infection
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• 15 days after inoculation with N. brasiliensis, intestines contain large numbers of adult worms while controls have expelled the worms by this time point
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hematopoietic system
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• mice make increased levels of IgG2 in response to N. brasiliensis infection
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il4ratm1Sz mutation
(2 available);
any
Il4ra mutation
(41 available)
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immune system
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• microglial cells fail to express the cell marker Ym1 (Chi3l3)
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• lower circulating levels of IgE in normal and bacterial infected mice
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• lower circulating levels in normal and bacterial infected mice
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• mice are unable to mount an effective Th2 response to N. brasiliensis bacteria as determined by Th2 cyotkine production by T cells
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• decrease production by T cells from mice infected with N. brasiliensis bacteria
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• decrease production of IL-4 by T cells from mice infected with N. brasiliensis bacteria
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• decrease production of IL-5 by T cells from mice infected with N. brasiliensis bacteria
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• mice immunized with recombinant vvG (vaccinia virus expressing the G protein of respiratory syncytial virus (RSV)) then challenged with RSV display lower percentages and total numbers of eosinophils in the bronchoalveolar lavage (BAL) compared to wild-type mice
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hematopoietic system
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• microglial cells fail to express the cell marker Ym1 (Chi3l3)
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• lower circulating levels of IgE in normal and bacterial infected mice
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• lower circulating levels in normal and bacterial infected mice
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• mice are unable to mount an effective Th2 response to N. brasiliensis bacteria as determined by Th2 cyotkine production by T cells
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nervous system
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• microglial cells fail to express the cell marker Ym1 (Chi3l3)
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immune system
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• in the thymus, as in Il7rtm1.1Asin/Il7rtm1Imx Tg(Cd8a*-cre)#Asin mice
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hematopoietic system
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• in the thymus, as in Il7rtm1.1Asin/Il7rtm1Imx Tg(Cd8a*-cre)#Asin mice
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respiratory system
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• enlarged alveoli and a histologic picture of emphysema are found, similar to that seen in tight skin heterozygotes with normal IL4RA expression
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immune system
N |
• unlike tight skin mice, these compound mutants do not develop autoantibodies against the scleroderma antigens topoisomerase I and fibrillin 1
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integument
N |
• the cutaneous hyperplasia found in tight skin heterozygotes is diminished in these compound mutants and the thickness of the skin is normal
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• electron micrographs of skin show a predominance of abnormally small diameter collagen fibers, although there is reduced fibrotic development compared with tight skin mice with wildtype expression of IL4RA
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Allelic Composition |
Fbn1Tsk/Fbn1+ Il4ratm1Sz/Il4ra+
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Genetic Background |
involves: BALB/cJ * C57BL/6J * C57BL/10 * DBA/2 |
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respiratory system
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• enlarged alveoli and a histologic picture of emphysema are found, similar to that seen in tight skin heterozygotes that are wildtype for Il4ra
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immune system
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• increased anti-topoisomerase antibodies relative to wildtype, but lower than in tight skin mice wildtype for Il4ra
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integument
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• the skin is as thick as tight skin heterozygotes wildtype for Il4ra
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