Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dll1tm1Gos mutation
(2 available);
any
Dll1 mutation
(46 available)
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mortality/aging
nervous system
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• overproduction of Isl1/Isl2+ motoneurons at E9.5 in the intermediate and ventral neural tube
• increase in the number of Chx10+ V2a, Gata3+ V2b and Evx1/Evx2+ V0 neurons at E10.5 in the intermediate and ventral neural tube
• expression analysis indicates and increase in the pace of neurogenesis
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• about a 40 - 50% reduction in the number of progenitor cells in the p0 domain of the spinal cord at E10.5
• progressive depletion of motorneuron progenitors over time
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• increase in the number of Chx10+ V2a, Gata3+ V2b and Evx1/Evx2+ V0 neurons at E10.5 in the intermediate and ventral neural tube
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• overproduction of Isl1/Isl2+ motoneurons at E9.5 in the intermediate and ventral neural tube
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cellular
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• overproduction of Isl1/Isl2+ motoneurons at E9.5 in the intermediate and ventral neural tube
• increase in the number of Chx10+ V2a, Gata3+ V2b and Evx1/Evx2+ V0 neurons at E10.5 in the intermediate and ventral neural tube
• expression analysis indicates and increase in the pace of neurogenesis
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Allelic
Composition |
Dll1tm1Gos/Dll1tm1Gos
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Genetic
Background |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dll1tm1Gos mutation
(2 available);
any
Dll1 mutation
(46 available)
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mortality/aging
embryo
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• tail rotation to the left in about 48% of embryos but random relative to heart looping
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• severe patterning defects in paraxial mesoderm
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• enlarged floor plate between E8.5 and E10.5
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• some regions appear as a sheet of cells associated with the dorsal primitive gut endoderm
• reduced number of notochord cells
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• rupture of surface, bulging of cells
• by late headfold stage, abnormal cell morphology disrupts symmetry
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• loss of monociliated cells
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• myoblasts span segment (somite) borders, indicating that borders are not maintained
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• irregularly shaped segments in the trunk
• distinct dermatomes present at E10.5 but segmental arrangement of myotome and sclerotome cells is disturbed
• myoblasts sometimes span space between adjacent segments
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• absence of segments in tail bud
• caudal sclerotome forms a uniform, loose, non segmental mass
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nervous system
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• excessive neuronal differentiation in CNS
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• enlarged floor plate between E8.5 and E10.5
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• wide
• irregularly spaced
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cardiovascular system
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• heart looping to the left in about 50% of embryos
• looping is sometimes incomplete at E8.5-9.5
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• severely hemorrhagic after E10
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endocrine/exocrine glands
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• pancreatic bud decreased in size
• composed primarily of endocrine cells
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cellular
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• loss of monociliated cells
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• excessive neuronal differentiation in CNS
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dll1tm1Gos mutation
(2 available);
any
Dll1 mutation
(46 available)
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immune system
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• in female, but not male, mice
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• in female, but not male, mice
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• female mice exhibit a decrease in CD8alpha,beta T cells compared with wild-type mice
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• male mice exhibit an increase in CD8alpha,beta T cells compared with wild-type mice
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homeostasis/metabolism
skeleton
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• whole body bone mineral content is reduced in female mice and tends to be reduced in male mice compared with wild-type mice
• however, bone content related to body weight is normal
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• whole body bone mineral density is reduced compared to in wild-type mice
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• specific bone mineral density is increased compared to in wild-type mice
• however, bone content related to body weight is normal
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growth/size/body
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• average body lean body mass and the average fat to lean mass ratio are reduced compared to in wild-type mice
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• at 6 weeks, average body weight is decreased compared with wild-type mice
• average fat-free dry mass is reduced compared to in wild-type mice
• however, body weight normalized to energy uptake is normal
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• mice are shorter than wild-type mice
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• mice fasted for 2 days exhibit a greater loss of body weight compared with similarly treated wild-type mice
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cardiovascular system
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• pulse and heart rate in female mice are decreased compared to in wild-type mice
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• the Q amplitude is increased compared to in wild-type mice
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• at 14 weeks in male mice
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• at 14 weeks in male mice
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• at 14 weeks in male mice
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adipose tissue
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• average body fat content and the average fat to lean mass ratio are reduced compared to in wild-type mice
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behavior/neurological
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• mice consume less food and have a reduced energy uptake compared with wild-type mice
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• mice exhibit a tendency towards reduced locomotor activity compared with wild-type mice
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digestive/alimentary system
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• mice produce less feces than wild-type mice
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hematopoietic system
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• in female, but not male, mice
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• in female, but not male, mice
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• female mice exhibit a decrease in CD8alpha,beta T cells compared with wild-type mice
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• male mice exhibit an increase in CD8alpha,beta T cells compared with wild-type mice
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Allelic
Composition |
Dll1tm1Gos/Dll1+
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Genetic
Background |
involves: 129S1/Sv * 129X1/SvJ |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dll1tm1Gos mutation
(2 available);
any
Dll1 mutation
(46 available)
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immune system
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• in female but not male mice
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• a non-significant reduction
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homeostasis/metabolism
growth/size/body
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• mice fasted for 2 days exhibit a greater loss of body weight compared with similarly treated wild-type mice
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skeleton
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• similar to on a C3 background, mice exhibit abnormal bone mineral density compared with wild-type mice
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hematopoietic system
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• in female but not male mice
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• a non-significant reduction
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dll1tm1Gos mutation
(2 available);
any
Dll1 mutation
(46 available)
Dll1tm2Gos mutation
(0 available);
any
Dll1 mutation
(46 available)
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mortality/aging
cardiovascular system
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• lumens of large arteries show a reduction in diameters at E18.5, with no significant differences in arterial wall thickness
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• lumen shows a reduction in diameter compared to controls
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• significant increase in capillary branch points in the skin is observed at E17.5
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• significant increase in capillary branch points in the skin is observed at E17.5
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muscle
integument
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• significant increase in capillary branch points in the skin is observed at E17.5
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Allelic
Composition |
Dll1tm1Gos/Dll1tm2Gos
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Genetic
Background |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dll1tm1Gos mutation
(2 available);
any
Dll1 mutation
(46 available)
Dll1tm2Gos mutation
(0 available);
any
Dll1 mutation
(46 available)
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mortality/aging
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• mice survive until birth
• mice do not survive postnatally
• however, mice survive beyond E10.5 when Dll1tm1Gos homozygotes die
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cellular
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• progenitor cells are lost due to premature differentiation and not an increase in apoptosis
• dermomyotome-derived myoblasts differentiate more rapidly than in wild-type mice
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• beginning at E14.5, the number of secondary myotubes are severely reduced
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muscle
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• progenitor cells are lost due to premature differentiation and not an increase in apoptosis
• dermomyotome-derived myoblasts differentiate more rapidly than in wild-type mice
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• beginning at E14.5, the number of secondary myotubes are severely reduced
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• at E13.5, skeletal muscle is hypotrophied
• at E18.5, skeletal muscle is severely reduced
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behavior/neurological
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• mice are motionless at E18.5
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embryo
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• mice exhibit defects in segmentation due to disrupted somitogenesis
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skeleton
growth/size/body
hearing/vestibular/ear
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• unlike in wild-type mice, cells within the organ of Corti continue to proliferate between E14.5 and E17.5
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• hair cells are disorganized and very densely packed
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• cochlea exhibit a greater increase in inner hair cells than in Jag2tm1Grid homozygotes
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• hair cell stereocilia bundles exhibit a lose of polarity and disorganization
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• many of the missing supporting cells are derived from the Deiter's cell population
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nervous system
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• hair cells are disorganized and very densely packed
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• cochlea exhibit a greater increase in inner hair cells than in Jag2tm1Grid homozygotes
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• hair cell stereocilia bundles exhibit a lose of polarity and disorganization
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hearing/vestibular/ear
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• cells within the organ of Corti, including pillar cells, Dieter's cells and Hensen's cells, continue to proliferate between E14.5 and E17.5 unlike in wild-type mice
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• cochlea exhibit a greater increase in inner hair cells than in Jag2tm1Grid homozygotes
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nervous system
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• cochlea exhibit a greater increase in inner hair cells than in Jag2tm1Grid homozygotes
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Allelic
Composition |
Dll1tm1Gos/Dll1+
Jag2tm1Grid/Jag2+
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Genetic
Background |
involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J |
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hearing/vestibular/ear
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• cochlea possess increased inner hair cells but not as many as in Jag2tm1Grid homozygotes
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nervous system
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• cochlea possess increased inner hair cells but not as many as in Jag2tm1Grid homozygotes
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Allelic
Composition |
Notch2tm1Grid/Notch2+
Dll1tm1Gos/Dll1+
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Genetic
Background |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J |
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renal/urinary system
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N |
• no kidney defects were observed despite expression of both genes in the developing glomerulus
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Analysis Tools