Phenotypes associated with this allele

• Allele Symbol: Vil1^tm1Syr
• Allele Name: targeted mutation 1, Sylvie Robine
• Allele ID: MGI:1859841
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Vil1^tm1Syr/Vil1^tm1Syr	involves: 129S2/SvPas * C57BL/6 * DBA/2	MGI:2653743
cn2	Hprt1^tm1(CAG-mCherry/Villin)Syr/? Vil1^tm1Syr/Vil1^tm1Syr Tg(Vil1-cre/ERT2)23Syr/0	involves: C57BL/6	MGI:5512864
cn3	Hprt1^tm2(CAG-mCherry/Villin*)Syr/? Vil1^tm1Syr/Vil1^tm1Syr Tg(Vil1-cre/ERT2)23Syr/0	involves: C57BL/6	MGI:5512865

Genotype
MGI:2653743

hm1

• Allelic Composition: Vil1^tm1Syr/Vil1^tm1Syr
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

impaired wound healing ( J:57346 )

• after oral administration of dextran sulfate sodium, increased numbers of large mucosal lesions in colonic epithelium and decreased median survival time was observed

Genotype
MGI:5512864

cn2

• Allelic Composition: Hprt1^{tm1(CAG-mCherry/Villin)Syr}/?; Vil1^tm1Syr/Vil1^tm1Syr; Tg(Vil1-cre/ERT2)23Syr/0
• Genetic Background: involves: C57BL/6

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:196199 )

N • after tamoxifen induction

N • injury repair after carbachol treatment is complete after 7 days as in control mice

N • columnar epithelium begins to flatten 30 minutes after injury with sodium deoxycholate

N • apico-basal polarity lost, microvillus disassembly

Genotype
MGI:5512865

cn3

• Allelic Composition: Hprt1^{tm2(CAG-mCherry/Villin*)Syr}/?; Vil1^tm1Syr/Vil1^tm1Syr; Tg(Vil1-cre/ERT2)23Syr/0
• Genetic Background: involves: C57BL/6

homeostasis/metabolism

impaired wound healing ( J:196199 )

• failure to heal properly at 3 and 7 days after carbachol treatment in tamoxifen induced mice

• very few cells in contact with sodium deoxycholate induced injury show polarity loss