Analysis Tools|
Allele Symbol Allele Name Allele ID |
Gli2+ wild type MGI:1858024 |
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| Summary |
12 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• gradual loss of hair beginning on the dorsal neck and preceding caudally down the back in mice over 3 weeks of age
• around 5 months of age mice lack hair around the neck
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• expression of ventral neural tube patterning markers is altered compared to in wild-type mice
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• expression of ventral neural tube patterning markers is altered compared to in wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• alveolar stem cell renewal is disrupted, with tamoxifen-treated mice showing reduced fractions of SFTPC+ alveolar stem cells that incorporate BrdU during normal homeostasis and during injury with bleomycin
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• tamoxifen-treated mice show reduced density of alveoli in the distal lung
• tamoxifen-treated mice exhibit a more simplified alveolar structure in which secondary crests are absent from the enlarged alveoli
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• tamoxifen-treated mice show a loss of SFTPC+ type 2 pneumocytes from the distal alveolar region
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• tamoxifen-treated mice show enlarged alveolus size
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• tamoxifen-treated mice exhibit emphysematous changes in the alveolar airspace characterized by a 20% enlargement of airspace, increase in mean chord length, enlarged alveolus size, and reduced density of alveoli in the distal lung
• lungs of tamoxifen-treated mice show elevated low attenuation volume/total lung volume ratio, indicating airspace enlargement and emphysema
• however, no evidence of increased inflammatory cells or increased in the number of apoptotic cells in the lungs of tamoxifen-treated mice are seen
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| pulmonary emphysema | DOID:9675 |
OMIM:130700 |
J:264185 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at E10.5
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• fused telencephalic vesicles are seen at E10.5
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• loss of many ventral tissues is seen at E10.5
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• at E10.5
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• females die by 6 weeks of age
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• polydactyl is enhanced compared to mice heterozygous for Gli3Xt-J alone
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• all males are sterile
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• hair loss is more severe compared to mice heterozygous for Gli2tm3.1(Gli2)Alj alone
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the motor neuron progenitor domain is greatly expanded dorsally however motor neuron appear to differentiate normally
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at E10.5, some floor plate cells have been lost
• in severely affected embryos, Foxa2-expressing cells are absent; Nkx2-2 interneurons are greatly reduced
• motor neurons occupy a more ventral position compared to controls
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• at E10.5, some floor plate cells have been lost
• in severely affected embryos, Foxa2-expressing cells are absent; Nkx2-2 interneurons are greatly reduced
• motor neurons occupy a more ventral position compared to controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• expression of ventral neural tube patterning markers is altered compared to in wild-type mice
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• expression of ventral neural tube patterning markers is altered compared to in wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• show an enhancement of the Gli3 null phenotype
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• neural arches of other cervical vertebrae are fused in addition to the fusion of the C1 and C2 neural arches
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• most die shortly after birth with only 3.8% surviving to weaning age
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• variable loss of cells expressing floor plate markers is seen in 2 of 5 mice in random patches in the posterior regions
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• at E12.5 and 14, notochord has not regressed from the ventral spinal cord
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• animals which survive to weaning are smaller
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• animals unable to right themselves
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• hopping gait
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• variable loss of cells expressing floor plate markers is seen in 2 of 5 mice in random patches in the posterior regions
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• motor neurons are located closer to the midline than normal
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• at E18.5, the left lobe is reduced in width
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• at E12.5, slight reduction in size of accessory lobe visible
• at E18.5, the accessory lobe is reduced in length and in width
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• at E18.5, the right cranial lobe is reduced in length
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• external genitalia are incompletely developed
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• at 5-7 weeks of age the gut is distended
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• some embryos lack mammary bud pair number 3 and number 5
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• some embryos lack mammary bud pair number 3 and number 5
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 01/06/2026 MGI 6.24 |
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