Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Soat1tm1Far mutation
(3 available);
any
Soat1 mutation
(40 available)
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Adrenal lipid depletion in Soat1tm1Far/Soat1tm1Far mice
endocrine/exocrine glands
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• adrenal glands are translucent and brownish instead of opaque and whitish-yellow as in wild-type and lack neutral lipids
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homeostasis/metabolism
hematopoietic system
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• reduction in cholesterol ester levels in peritoneal macrophages
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immune system
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• reduction in cholesterol ester levels in peritoneal macrophages
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liver/biliary system
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• hepatic cholesterol ester levels are 30% lower in mutants fed a chow diet but are similar to wild-type when fed a high-fat diet
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Apoetm1Unc/Apoetm1Unc Soat1tm1Far/Soat1tm1Far mice display severe xanthomatosis
homeostasis/metabolism
cardiovascular system
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• mutants fed a Western diet develop atherosclerotic lesions, however lesions are smaller than in single Apoe homozygotes
• aortic lesion composition differs from that in Apoe homozygotes, with lower neutral lipid content and fewer cholesterol crystals and a paucity of macrophages in the most advanced lesions
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immune system
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• cholesterol deposition in the skin is accompanied by a severe, pleomorphic inflammatory cell infiltrate with features of acute and chronic inflammation, including large numbers of neutrophils, multinucleated giant cells with occasional intracellular cholesterol clefts, and frequent mononuclear cells, lymphocytes, and plasma cells
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nervous system
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• free cholesterol crystal deposits are seen in brains of mutants fed a Western diet for 3 months, mostly near the choroid plexus
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integument
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• cholesterol deposition in the skin is accompanied by a severe, pleomorphic inflammatory cell infiltrate with features of acute and chronic inflammation, including large numbers of neutrophils, multinucleated giant cells with occasional intracellular cholesterol clefts, and frequent mononuclear cells, lymphocytes, and plasma cells
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• by 2-3 months of age, fur appears dull and mutants show pruritus
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• diffuse hair loss occurs by 5-6 months of age and leads to severe lesions
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• free cholesterol content of the skin is 6- to 7-fold higher than in controls at 4 months of age
• mutants fed a Western diet exhibit more severe skin changes and at an earlier age (6 weeks) than wild-type or mutants fed a chow diet
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• the dermis exhibits diffuse needle-shaped lucencies indicative of cholesterol crystals; crystals appear predominantly extracellularly and are seen in or below the reticular dermis
• deeper layers of the dermis show marked proliferation of fibroblasts and extensive collagen deposition
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• hyperkeratosis at the skin surface
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• develop severe skin lesions within months when fed a chow diet
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• by 2-3 months of age, show pruritus
• by 5-6 months of age, excoriation occurs and leads to severe lesions
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Soat1tm1Far/Soat1tm1Far Ldlrtm1Her/Ldlrtm1Her mice fed an atherogenic diet for 2 months display severe xanthomatosis
homeostasis/metabolism
cardiovascular system
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• mutants fed a Western diet develop atherosclerotic lesions
• aortic lesion composition differs from that in Apoe homozygotes, with lower neutral lipid content and fewer cholesterol crystals
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immune system
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• severe, pleomorphic inflammatory reaction accompanies the cholesterol deposition in atherogenic diet fed mutants, however the features are different from those in double Soat1 and Apoe mutants
• inflammatory cells are predominantly macrophages, lymphocytes, and plasma cells, with fewer neutrophils than in double Soat1 and Apoe mutants
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nervous system
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• mutants fed an atherogenic diet exhibit crystalline cholesterol deposits in the brains, particularly near the choroid plexus and in the cerebellum
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• mutants fed an atherogenic diet exhibit crystalline cholesterol deposits in the cerebellum
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integument
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• skin of mutants fed an atherogenic diet shows edematous lesions
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• severe, pleomorphic inflammatory reaction accompanies the cholesterol deposition in atherogenic diet fed mutants, however the features are different from those in double Soat1 and Apoe mutants
• inflammatory cells are predominantly macrophages, lymphocytes, and plasma cells, with fewer neutrophils than in double Soat1 and Apoe mutants
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• diffuse deposition of cholesterol crystals in the reticular and papillary dermis of mutants fed an atherogenic diet
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• skin lesions are seen only when mutants are fed a Western diet and not when fed a chow diet
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• mutants fed an atherogenic diet, but not a chow diet, develop diffuse, massive thickening of the skin compared to single Ldlr mutants
• however, do not develop skin excoriations, hair loss or pruritic skin
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Analysis Tools