All Phenotypes Bmp8b<tm1Blh> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bmp8b^tm1Blh/Bmp8b^tm1Blh	B6.129-Bmp8b^tm1Blh	MGI:2656839
hm2	Bmp8b^tm1Blh/Bmp8b^tm1Blh	either: B6.129-Bmp8b^tm1Blh or (involves: 129 * Black Swiss * C57BL/6)	MGI:2451100
hm3	Bmp8b^tm1Blh/Bmp8b^tm1Blh	involves: 129/Sv * Black Swiss	MGI:2451094
ht4	Bmp8b^tm1Blh/Bmp8b⁺	either: B6.129-Bmp8b^tm1Blh or (involves: 129 * Black Swiss * C57BL/6)	MGI:2451099
cx5	Bmp4^tm1Blh/Bmp4⁺ Bmp8b^tm1Blh/Bmp8b⁺	involves: 129/Sv * 129S2/SvPas * Black Swiss	MGI:3834139
cx6	Bmp8a^tm1Blh/Bmp8a⁺ Bmp8b^tm1Blh/Bmp8b⁺	involves: 129/Sv * 129S6/SvEvTac * Black Swiss	MGI:2450605

Allelic Composition	Bmp8b^tm1Blh/Bmp8b^tm1Blh
Genetic Background	B6.129-Bmp8b^tm1Blh

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp8b^tm1Blh mutation (1 available); any Bmp8b mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:63160 )

• Background Sensitivity: by the 6th backcross generation onto C57BL/6, only 33% of expected homozygotes are viable after E9.25

• Background Sensitivity: occurring in N6 backcross generation onto C57BL/6, but not N5

embryo

delayed embryo turning ( J:63160 )

• 25% of embryos show delayed turning

embryonic growth retardation ( J:63160 )

• seen at E8.75-E9.25

absent allantois ( J:63160 )

• sometimes absent

small allantois ( J:63160 )

• shorter allantois length

growth/size/body

embryonic growth retardation ( J:63160 )

• seen at E8.75-E9.25

reproductive system

absent primordial germ cells ( J:63160 )

cellular

absent primordial germ cells ( J:63160 )

Allelic Composition	Bmp8b^tm1Blh/Bmp8b^tm1Blh
Genetic Background	either: B6.129-Bmp8b^tm1Blh or (involves: 129 * Black Swiss * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp8b^tm1Blh mutation (1 available); any Bmp8b mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

delayed embryo turning ( J:63160 )

• 25% of mice exhibit delayed turning, N2-N6 backcross generation onto C57BL/6

absent allantois ( J:63160 )

• Background Sensitivity: 25% of mice lack an allantois, N2-N6 backcross generation onto C57BL/6

small allantois ( J:63160 )

• shorter allantois length at the headfold stage

reproductive system

absent primordial germ cells ( J:63160 )

• 92% of mutant embryos on a largely C57BL/6 background have no primordial germ cells

cellular

absent primordial germ cells ( J:63160 )

• 92% of mutant embryos on a largely C57BL/6 background have no primordial germ cells

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal male germ cell morphology ( J:34057 )

• 50% of mutant embryos show delayed male germ cell differentiation

decreased male germ cell number ( J:34057 )

• during early puberty

• complete germ cell depletion in all sterile males

• partial germ cell depletion in fertile males

abnormal primordial germ cell morphology ( J:63160 )

• primordial germ cell generation is delayed, with mutants showing no primordial germ cells at the late streak stage

decreased primordial germ cell number ( J:63160 )

• 57% of mutants have less than 40 primordial germ cells before the 24-somite stage

absent primordial germ cells ( J:63160 )

• 43% of mutants have no primordial germ cells

increased male germ cell apoptosis ( J:34057 )

• increase in apoptosis of germ cells in the degenerating seminiferous tubules

abnormal cell differentiation ( J:34057 )

• 50% of mutant embryos show delayed male germ cell differentiation

abnormal spermatogonia proliferation ( J:34057 )

• numbers of proliferating spermatogonia in the seminiferous tubules are decreased at 2 weeks of age

endocrine/exocrine glands

abnormal seminiferous tubule epithelium morphology ( J:34057 , J:46927 )

• the seminiferous epithelium contians only a single cell layer at 3 and 5 weeks of age (J:34057)

• in severe cases, only one layer of epithelium is present in the seminiferous tubule (J:46927)

small seminiferous tubules ( J:34057 )

seminiferous tubule degeneration ( J:34057 , J:46927 )

• tubules lack primary spermatocytes (J:34057)

• irregular elongated spermatids in the center (J:34057)

• spermatogonia and Sertoli cells at the periphery (J:34057)

• increased apoptosis of pachytene spermatocytes in early adulthood (J:34057)

(J:46927)

increased Leydig cell number ( J:34057 )

• local accumulation of interstitial Leydig cells in the seminiferous tubules in completely degenerated ares of the testis

small testis ( J:34057 , J:46927 )

• reduced testis size in fertile males (J:34057)

• testis size in sterile males is about 15% the size of testis in heterozygous littermates or wild-type mice (J:34057)

(J:46927)

decreased testis weight ( J:34057 )

testis degeneration ( J:34057 )

• complete testis degeneration in all sterile males

• partial degeneration in fertile males

reproductive system

abnormal male germ cell morphology ( J:34057 )

• 50% of mutant embryos show delayed male germ cell differentiation

decreased male germ cell number ( J:34057 )

• during early puberty

• complete germ cell depletion in all sterile males

• partial germ cell depletion in fertile males

abnormal primordial germ cell morphology ( J:63160 )

• primordial germ cell generation is delayed, with mutants showing no primordial germ cells at the late streak stage

decreased primordial germ cell number ( J:63160 )

• 57% of mutants have less than 40 primordial germ cells before the 24-somite stage

absent primordial germ cells ( J:63160 )

• 43% of mutants have no primordial germ cells

abnormal seminiferous tubule epithelium morphology ( J:34057 , J:46927 )

• the seminiferous epithelium contians only a single cell layer at 3 and 5 weeks of age (J:34057)

• in severe cases, only one layer of epithelium is present in the seminiferous tubule (J:46927)

small seminiferous tubules ( J:34057 )

seminiferous tubule degeneration ( J:34057 , J:46927 )

• tubules lack primary spermatocytes (J:34057)

• irregular elongated spermatids in the center (J:34057)

• spermatogonia and Sertoli cells at the periphery (J:34057)

• increased apoptosis of pachytene spermatocytes in early adulthood (J:34057)

(J:46927)

increased Leydig cell number ( J:34057 )

• local accumulation of interstitial Leydig cells in the seminiferous tubules in completely degenerated ares of the testis

small testis ( J:34057 , J:46927 )

• reduced testis size in fertile males (J:34057)

• testis size in sterile males is about 15% the size of testis in heterozygous littermates or wild-type mice (J:34057)

(J:46927)

decreased testis weight ( J:34057 )

testis degeneration ( J:34057 )

• complete testis degeneration in all sterile males

• partial degeneration in fertile males

abnormal spermatogenesis ( J:34057 )

• germ cell proliferation at puberty is blocked in 20-30% of testes

• delayed and reduced germ cell proliferation and differentiation in the remainder of testes

abnormal spermatogonia proliferation ( J:34057 )

• numbers of proliferating spermatogonia in the seminiferous tubules are decreased at 2 weeks of age

abnormal reproductive system physiology ( J:63160 )

• primordial germ cell generation is delayed, with mutants showing no primordial germ cells at the late streak stage

increased male germ cell apoptosis ( J:34057 )

• increase in apoptosis of germ cells in the degenerating seminiferous tubules

male infertility ( J:34057 )

• 10 of 18 homozygous males are sterile

embryo

embryonic growth retardation ( J:63160 )

• most embryos are developmentally retarded at E7.5-8.25

abnormal allantois morphology ( J:63160 )

• allantois is more elongated at the headfold stage, but is shorter overall than in wild-type

small allantois ( J:63160 )

delayed allantois development ( J:63160 )

• no allantoic bud is seen at the late streak stage and only a small bud is present at the neural plate stage indicating delayed allantois initiation

growth/size/body

embryonic growth retardation ( J:63160 )

• most embryos are developmentally retarded at E7.5-8.25

Allelic Composition	Bmp8b^tm1Blh/Bmp8b⁺
Genetic Background	either: B6.129-Bmp8b^tm1Blh or (involves: 129 * Black Swiss * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp8b^tm1Blh mutation (1 available); any Bmp8b mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

decreased primordial germ cell number ( J:63160 )

• reduced number of PGCs in mice on a largely C57BL/6 background

• at the headfold stage, the mean number of PBCs is about 60% that of wild-type

cellular

decreased primordial germ cell number ( J:63160 )

• reduced number of PGCs in mice on a largely C57BL/6 background

• at the headfold stage, the mean number of PBCs is about 60% that of wild-type

Allelic Composition	Bmp4^tm1Blh/Bmp4⁺ Bmp8b^tm1Blh/Bmp8b⁺
Genetic Background	involves: 129/Sv * 129S2/SvPas * Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp4^tm1Blh mutation (2 available); any Bmp4 mutation (21 available)
Bmp8b^tm1Blh mutation (1 available); any Bmp8b mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

decreased primordial germ cell number ( J:63160 )

• number of primordial germ cells is lower than in wild-type, but similar to numbers seen in Bmpb8 heterozygotes

cellular

decreased primordial germ cell number ( J:63160 )

• number of primordial germ cells is lower than in wild-type, but similar to numbers seen in Bmpb8 heterozygotes

Allelic Composition	Bmp8a^tm1Blh/Bmp8a⁺ Bmp8b^tm1Blh/Bmp8b⁺
Genetic Background	involves: 129/Sv * 129S6/SvEvTac * Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp8a^tm1Blh mutation (0 available); any Bmp8a mutation (19 available)
Bmp8b^tm1Blh mutation (1 available); any Bmp8b mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal male germ cell morphology ( J:46927 )

• about half of male mice examined exhibited abnormalities similar to homozygous Bmp8a^tm1Blh mice

abnormal spermatogenesis ( J:46927 )

• about 50% of male mice examined exhibited abnormalities similar to Bmp8a^tm1Blh/ Bmp8a^tm1Blh mice

epididymis epithelium degeneration ( J:46927 )

• is sometimes observed

immune system

granulomatous inflammation ( J:46927 )

• is sometimes noted in the epididymal tubules of breeding male mice

cellular

abnormal male germ cell morphology ( J:46927 )

• about half of male mice examined exhibited abnormalities similar to homozygous Bmp8a^tm1Blh mice

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