All Phenotypes Hnf1b<+> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Hnf1b^tm2Ics/Hnf1b⁺	involves: 129 * C57BL/6N	MGI:6716064
cn2	Hnf1b^tm1Sce/Hnf1b⁺ Wnt4^{tm2(EGFP/cre)Svo}/Wnt4⁺	involves: 129P2/OlaHsd	MGI:5471842
cn3	Hnf1b^tm1Ics/Hnf1b⁺ Wnt4^{tm2(EGFP/cre)Svo}/Wnt4⁺	involves: 129P2/OlaHsd	MGI:5471841

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

decreased pancreatic acinar cell number ( J:306082 )

• at age 3 months

pancreatic acinar hypoplasia ( J:306082 )

• few acinar lobules

abnormal pancreatic duct morphology ( J:306082 )

• shorter primary cilia on ductal cells at age 3 months

endocrine/exocrine glands

decreased pancreatic acinar cell number ( J:306082 )

• at age 3 months

pancreatic acinar hypoplasia ( J:306082 )

• few acinar lobules

abnormal pancreatic duct morphology ( J:306082 )

• shorter primary cilia on ductal cells at age 3 months

decreased pancreatic islet number ( J:306082 )

• 20% reduction of total islet volume

• 28% reduction of total large islet volume

• 22% reduction in number of large islets

small pancreatic islets ( J:306082 )

• reduction in individual large islet volume

• 20% reduction of total islet volume

• 28% reduction of total large islet volume

pancreas fibrosis ( J:306082 )

pancreas lipomatosis ( J:306082 )

pancreatic acinar-to-ductal metaplasia ( J:306082 )

decreased insulin secretion ( J:306082 )

• 65% reduction in pancreatic insulin levels

• normal glucose-stimulated insulin secretion by isolated islets in vitro

chronic pancreas inflammation ( J:306082 )

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:306082 )

N	• normal peripheral insulin sensitivity in insulin tolerance test (ITT) at age 24 weeks

decreased insulin secretion ( J:306082 )

• 65% reduction in pancreatic insulin levels

• normal glucose-stimulated insulin secretion by isolated islets in vitro

increased fasting circulating glucose level ( J:306082 )

hyperglycemia ( J:306082 )

decreased circulating insulin level ( J:306082 )

• at age 12 weeks

impaired glucose tolerance ( J:306082 )

• higher blood glucose levels in the intraperitoneal glucose tolerance tests (IPGTT)

immune system

chronic pancreas inflammation ( J:306082 )

Allelic Composition	Hnf1b^tm1Sce/Hnf1b⁺ Wnt4^{tm2(EGFP/cre)Svo}/Wnt4⁺
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hnf1b^tm1Sce mutation (2 available); any Hnf1b mutation (16 available)
Wnt4^{tm2(EGFP/cre)Svo} mutation (1 available); any Wnt4 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

renal/urinary system phenotype ( J:194051 )

N	• glomerular cysts and enlarged tubules are not seen, unlike in mice heterozygous for Hnf1b^tm1Ics and Wnt4^{tm2(EGFP/cre)Svo}

Allelic Composition	Hnf1b^tm1Ics/Hnf1b⁺ Wnt4^{tm2(EGFP/cre)Svo}/Wnt4⁺
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hnf1b^tm1Ics mutation (0 available); any Hnf1b mutation (16 available)
Wnt4^{tm2(EGFP/cre)Svo} mutation (1 available); any Wnt4 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

renal glomerulus cyst ( J:194051 )

• in some mice

abnormal renal tubule morphology ( J:194051 )

• enlarged, more obvious at E15.5 than at P0

growth/size/body

renal glomerulus cyst ( J:194051 )

• in some mice

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