Phenotypes associated with this allele

• Allele Symbol: Foxa2⁺
• Allele Name: wild type
• Allele ID: MGI:1857728
• Summary: 17 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Foxa2^tm1.1Khk/Foxa2^+	involves: 129P2/OlaHsd * C57BL/6 * CD-1	MGI:6393317
ht2	Foxa2^tm1Dnl/Foxa2^+	involves: 129P2/OlaHsd * C57BL/6J	MGI:3849568
ht3	Foxa2^tm1Jrt/Foxa2^+	involves: 129S1/Sv * 129X1/SvJ	MGI:3625857
ht4	Foxa2^tm1Jrt/Foxa2^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:2177168
ht5	Foxa2^tm1Jrt/Foxa2^+	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:2177169
cn6	Foxa2^tm2.1(cre/Esr1*)Moon/Foxa2^+ Nkx2-5^tm1Krc/Nkx2-5^tm1Krc	involves: 129 * C57BL/6	MGI:5643695
cn7	Foxa1^tm1Khk/Foxa1^tm1Khk Foxa2^tm1Khk/Foxa2^+ Tg(Pdx1-cre)6Cvw/0	involves: 129 * C57BL/6 * CBA * SJL	MGI:3831161
cn8	Nipbl^Gt(EUCE313f02)1.1Hmgu/Nipbl^+ Foxa2^tm1(cre)Heli/Foxa2^+	involves: 129P2/OlaHsd * 129S2/SvPas * CD-1	MGI:7492232
cn9	Hes1^tm1Kag/Hes1^tm1Kag Foxa2^tm3.1(icre)Heli/Foxa2^+	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:5428766
cn10	Mib1^tm2Kong/Mib1^tm2Kong Foxa2^tm3.1(icre)Heli/Foxa2^+	involves: 129P2/OlaHsd * C57BL/6 * SJL	MGI:5428765
cn11	Gt(ROSA)26Sor^tm1.1(Maml1/EGFP)Hri/? Foxa2^tm3.1(icre)Heli/Foxa2^+	involves: 129P2/OlaHsd * C57BL/6 * SJL	MGI:5428767
cn12	Dll1^tm1.1Hri/Dll1^tm1.1Hri Foxa2^tm3.1(icre)Heli/Foxa2^+	involves: 129P2/OlaHsd * C57BL/6 * SJL	MGI:5428768
cn13	Fgfr1^tm3.2Cxd/Fgfr1^tm3.2Cxd Fgfr2^tm1Dor/Fgfr2^tm1Dor Foxa2^tm2.1(cre/Esr1*)Moon/Foxa2^+	involves: 129S6/SvEvTac * 129X1/SvJ	MGI:3829047
cn14	Fgf8^tm1Mrc/Fgf8^tm2Moon Foxa2^tm2.1(cre/Esr1*)Moon/Foxa2^+	Not Specified	MGI:3829041
cx15	Foxa2^tm1Jrt/Foxa2^+ Gsc^tm1Bhr/Gsc^tm1Bhr	involves: 129 * C57BL/6 * CD-1	MGI:2169198
cx16	9030622O22Rik^em1Eem/9030622O22Rik^+ Foxa2^tm1.1Khk/Foxa2^+	involves: 129P2/OlaHsd * C57BL/6 * CD-1	MGI:6393316
cx17	Foxa2^tm1Jrt/Foxa2^+ Nodal^tm1Rob/Nodal^+	involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ	MGI:3625856

Genotype
MGI:6393317

ht1

• Allelic Composition: Foxa2^tm1.1Khk/Foxa2⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

respiratory system

respiratory system inflammation ( J:284174 )

• mice exhibit areas of peribronchial and perivascular inflammation

abnormal respiratory mucosa goblet cell morphology ( J:284174 )

• goblet cell metaplasia

homeostasis/metabolism

increased susceptibility to injury ( J:284174 )

• mice show defects in regeneration of the airway epithelium after injury with naphthalene, including incomplete re-epithelialization of the lung airways, peribronchial and perivascular inflammation, goblet cell metaplasia

immune system

respiratory system inflammation ( J:284174 )

• mice exhibit areas of peribronchial and perivascular inflammation

Genotype
MGI:3849568

ht2

• Allelic Composition: Foxa2^tm1Dnl/Foxa2⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

mortality/aging

neonatal lethality, incomplete penetrance ( J:19896 )

• about 10% of mice die within 24 h of birth

growth/size/body

malocclusion ( J:19896 )

• seen in over 50% of mice

reproductive system

absent estrus ( J:19896 )

♀ • almost 50% of females fail to pass through estrus

absent estrous cycle ( J:19896 )

♀

increased miscarriage rate ( J:19896 )

♀ • fewer than 50% of females carry embryos to term

reduced female fertility ( J:19896 )

♀

behavior/neurological

impaired righting response ( J:19896 )

• many are unable to right themselves when placed on their backs

abnormal gait ( J:19896 )

• circular gait

homeostasis/metabolism

increased circulating free fatty acids level ( J:95662 )

increased circulating triglyceride level ( J:95662 )

abnormal glucose homeostasis ( J:95662 )

• hepatic glucose output is elevated and hepatic insulin sensitivity is reduced in mice fed a high fat diet

increased liver triglyceride level ( J:95662 )

• increased hepatic levels

abnormal metabolism ( J:95662 )

• ketogenesis is significantly decreased in mice fed a standard chow diet and this reduction is more severe in mice fed a high fat diet

• beta-oxidation is reduced in mice fed a high fat diet

skeleton

malocclusion ( J:19896 )

• seen in over 50% of mice

craniofacial

malocclusion ( J:19896 )

• seen in over 50% of mice

liver/biliary system

increased liver triglyceride level ( J:95662 )

• increased hepatic levels

Genotype
MGI:3625857

ht3

• Allelic Composition: Foxa2^tm1Jrt/Foxa2⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

mortality/aging

premature death ( J:19895 )

• some of those that survive until weaning die by 3 months of age

postnatal lethality ( J:19895 )

• Background Sensitivity: loss prior to weaning is higher on a mixed 129 and C57BL/6 background than on a 129 background

craniofacial

long incisors ( J:19895 )

• overgrowth of the upper and lower incisors is seen in mice with malocclusion

malocclusion ( J:19895 )

• malocclusion of the jaws is seen in those that die by 3 months of age

behavior/neurological

hunched posture ( J:19895 )

• seen in those that die by 3 months of age

circling ( J:19895 )

• seen in those that die by 3 months of age

growth/size/body

long incisors ( J:19895 )

• overgrowth of the upper and lower incisors is seen in mice with malocclusion

malocclusion ( J:19895 )

• malocclusion of the jaws is seen in those that die by 3 months of age

decreased body size ( J:19895 )

• seen in those that die by 3 months of age

skeleton

long incisors ( J:19895 )

• overgrowth of the upper and lower incisors is seen in mice with malocclusion

malocclusion ( J:19895 )

• malocclusion of the jaws is seen in those that die by 3 months of age

Genotype
MGI:2177168

ht4

• Allelic Composition: Foxa2^tm1Jrt/Foxa2⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

mortality/aging

premature death ( J:19895 )

• some of those that survive until weaning die by 3 months of age

postnatal lethality ( J:19895 )

• Background Sensitivity: loss prior to weaning is higher on a mixed 129 and C57BL/6 background than on a 129 background

craniofacial

long incisors ( J:19895 )

• overgrowth of the upper and lower incisors is seen in mice with malocclusion

malocclusion ( J:19895 )

• malocclusion of the jaws is seen in those that die by 3 months of age

behavior/neurological

hunched posture ( J:19895 )

• seen in those that die by 3 months of age

circling ( J:19895 )

• seen in those that die by 3 months of age

growth/size/body

long incisors ( J:19895 )

• overgrowth of the upper and lower incisors is seen in mice with malocclusion

malocclusion ( J:19895 )

• malocclusion of the jaws is seen in those that die by 3 months of age

decreased body size ( J:19895 )

• seen in those that die by 3 months of age

skeleton

long incisors ( J:19895 )

• overgrowth of the upper and lower incisors is seen in mice with malocclusion

malocclusion ( J:19895 )

• malocclusion of the jaws is seen in those that die by 3 months of age

Genotype
MGI:2177169

ht5

• Allelic Composition: Foxa2^tm1Jrt/Foxa2⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

mortality/aging

premature death ( J:19895 )

• about 20% of those that survive until weaning die by 3 months of age and display abnormalities

postnatal lethality ( J:19895 )

• Background Sensitivity: loss prior to weaning is higher on a mixed 129 and C57BL/6 background than on a 129 background or mixed 129 and CD-1 background

craniofacial

long incisors ( J:19895 )

• overgrowth of the upper and lower incisors is seen in mice with malocclusion

malocclusion ( J:19895 )

• malocclusion of the jaws is seen in those that die by 3 months of age

behavior/neurological

hunched posture ( J:19895 )

• seen in those that die by 3 months of age

circling ( J:19895 )

• seen in those that die by 3 months of age

growth/size/body

long incisors ( J:19895 )

• overgrowth of the upper and lower incisors is seen in mice with malocclusion

malocclusion ( J:19895 )

• malocclusion of the jaws is seen in those that die by 3 months of age

decreased body size ( J:19895 )

• seen in those that die by 3 months of age

skeleton

long incisors ( J:19895 )

• overgrowth of the upper and lower incisors is seen in mice with malocclusion

malocclusion ( J:19895 )

• malocclusion of the jaws is seen in those that die by 3 months of age

Genotype
MGI:5643695

cn6

• Allelic Composition: Foxa2^{tm2.1(cre/Esr1*)Moon}/Foxa2⁺; Nkx2-5^tm1Krc/Nkx2-5^tm1Krc
• Genetic Background: involves: 129 * C57BL/6

cardiovascular system

cardiovascular system phenotype ( J:214093 )

N • pups from pregnant females treated with tamoxifen at E6.5-7 do not exhibit outflow tract septation or alignment defects

Genotype
MGI:3831161

cn7

• Allelic Composition: Foxa1^tm1Khk/Foxa1^tm1Khk; Foxa2^tm1Khk/Foxa2⁺; Tg(Pdx1-cre)6Cvw/0
• Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:143476 )

N • unlike in mice lacking both alleles of Fox2a, pancreatic development is normal

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:143476 )

N • mice are euglycemic

Genotype
MGI:7492232

cn8

• Allelic Composition: Nipbl^{Gt(EUCE313f02)1.1Hmgu}/Nipbl⁺; Foxa2^tm1(cre)Heli/Foxa2⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * CD-1

cardiovascular system

atrial septal defect ( J:236978 )

• in 26% of hearts at E17.5

Genotype
MGI:5428766

cn9

• Allelic Composition: Hes1^tm1Kag/Hes1^tm1Kag; Foxa2^{tm3.1(icre)Heli}/Foxa2⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

endocrine/exocrine glands

abnormal pancreas development ( J:184814 )

• embryos show an increase in Neurog3+ve cells at E9.5; by E10.5, an increase in glucagon+ve cells is seen

• at E15.5, the insulin +ve area of the pancreatic tissue is reduced by 65% compared to control embryos similar to the dnMaml-expressing embryos

• some DBA+ve cells are observed in E18.5 embryos

• proximal-distal patterning is altered in the embryonic pancreas; at E15.5, Nkx6-1+ve, Ptf1a-ve cells are reduced in the proximal domain by 85% while Hnf1b and DBA+ve cells are reduced in number with a concurrent increase in Nkx6-1-ve, Ptf1a+ve cells as well as Cpa+ve and amylase +ve cells

• Nkx6-1 and Ptf1a double-positive cells are observed in significant numbers

• at E12.5, Nkx6-1+ve Ptf1a-ve are present, but reduced in numbers by 50% compared to controls along with no increase in Nkx6-1-ve Ptf1a+ve cells

abnormal pancreatic beta cell differentiation ( J:184814 )

• at E15.5, the insulin +ve area of the pancreatic tissue is reduced by 65% compared to control embryos

cellular

abnormal pancreatic beta cell differentiation ( J:184814 )

• at E15.5, the insulin +ve area of the pancreatic tissue is reduced by 65% compared to control embryos

Genotype
MGI:5428765

cn10

• Allelic Composition: Mib1^tm2Kong/Mib1^tm2Kong; Foxa2^{tm3.1(icre)Heli}/Foxa2⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

endocrine/exocrine glands

absent pancreatic duct ( J:184814 )

• loss of DBA+ve (D. biflorus agglutinin) duct structures is observed by E18.5

abnormal pancreas development ( J:184814 )

• at E9.5, an excess of Neurog3+ve cells is found in the dorsal pancreatic bud; near complete conversion of dorsal bud cells to glucagon+ve cells occurs by E10.5

• at E10.5, dorsal pancreas is absent, but ventral pancreatic anlage forms normally

• proximal-distal patterning is altered in the embryonic pancreas; at E15.5, Nkx6-1+ve, Ptf1a-ve cells are absent from the proximal domain while Hnf1b and DBA+ve cells are also lost, with a concurrent increase in Nkx6-1-ve, Ptf1a+ve cells as well as Cpa+ve and amylase +ve cells

• at E12.5, Nkx6-1+ve Ptf1a-ve are present, but reduced in numbers by 50% compared to controls along with a corresponding increase in Nkx6-1-ve Ptf1a+ve cells

abnormal pancreatic beta cell differentiation ( J:184814 )

• insulin-producing cells are absent by E18.5

digestive/alimentary system

absent pancreatic duct ( J:184814 )

• loss of DBA+ve (D. biflorus agglutinin) duct structures is observed by E18.5

cellular

abnormal pancreatic beta cell differentiation ( J:184814 )

• insulin-producing cells are absent by E18.5

Genotype
MGI:5428767

cn11

• Allelic Composition: Gt(ROSA)26Sor^{tm1.1(Maml1/EGFP)Hri}/?; Foxa2^{tm3.1(icre)Heli}/Foxa2⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

endocrine/exocrine glands

abnormal pancreas development ( J:184814 )

• embryos show an increase in Neurog3+ve cells at E9.5; by E10.5, an increase in glucagon+ve cells is seen

• at E15.5, the insulin +ve area of the pancreatic tissue is reduced by 65% compared to control embryos

• proximal-distal patterning is altered in the embryonic pancreas; at E15.5, Nkx6-1+ve, Ptf1a-ve cells are reduced in the proximal domain by 75% while Hnf1b and DBA+ve cells are reduced in number

• at E12.5, Nkx6-1+ve Ptf1a-ve are present, but reduced in numbers by 50% compared to controls along with a corresponding increase in Nkx6-1-ve Ptf1a+ve cells

abnormal pancreatic beta cell differentiation ( J:184814 )

• at E15.5, the insulin +ve area of the pancreatic tissue is reduced by 65% compared to control embryos

cellular

abnormal pancreatic beta cell differentiation ( J:184814 )

• at E15.5, the insulin +ve area of the pancreatic tissue is reduced by 65% compared to control embryos

Genotype
MGI:5428768

cn12

• Allelic Composition: Dll1^tm1.1Hri/Dll1^tm1.1Hri; Foxa2^{tm3.1(icre)Heli}/Foxa2⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

endocrine/exocrine glands

abnormal pancreas development ( J:184814 )

• at E10.5, an excessive formation of glucagon +ve cells is observed

• reduced numbers of Nkx6-1+ve Ptf1a-ve cells are detected at E12.5

• however, no apparent defects in proximal-distal patterning in E15.5 and E18.5 embryos are observed

Genotype
MGI:3829047

cn13

• Allelic Composition: Fgfr1^tm3.2Cxd/Fgfr1^tm3.2Cxd; Fgfr2^tm1Dor/Fgfr2^tm1Dor; Foxa2^{tm2.1(cre/Esr1*)Moon}/Foxa2⁺
• Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

mortality/aging

mortality/aging ( J:143444 )

N • despite disruption of vascular development mice survive to birth

cardiovascular system

cardiovascular system phenotype ( J:143444 )

N • despite ubiquitous expression of these genes in the anterior of the embryo, no defects in outflow tract development are seen

abnormal vascular development ( J:143444 )

• disruption of vascular development

Genotype
MGI:3829041

cn14

• Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm2Moon; Foxa2^{tm2.1(cre/Esr1*)Moon}/Foxa2⁺
• Genetic Background: Not Specified

cardiovascular system

cardiovascular system phenotype ( J:143444 )

N • no defects in outflow tract development are seen

Genotype
MGI:2169198

cx15

• Allelic Composition: Foxa2^tm1Jrt/Foxa2⁺; Gsc^tm1Bhr/Gsc^tm1Bhr
• Genetic Background: involves: 129 * C57BL/6 * CD-1

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:41809 )

• die around E11.5

embryo

abnormal pharyngeal arch morphology ( J:41809 )

• abnormal at E8.75

abnormal first pharyngeal arch morphology ( J:41809 )

• pyknotic cells are seen in the mesenchyme of the first branchial arches

• the first branchial arch arteries are either not visible or poorly formed

• epithelium of the first arch fails to fuse ventrally with the pharyngeal endoderm

abnormal first pharyngeal arch artery morphology ( J:41809 )

• the first branchial arch arteries are either not visible or poorly formed

small first pharyngeal arch ( J:41809 )

• at E9.5

• expression analysis indicates reduced populations of both mesodermal and neural crest cells

abnormal second pharyngeal arch morphology ( J:41809 )

• pyknotic cells are seen in the mesenchyme of the second branchial arches

small second pharyngeal arch ( J:41809 )

• at E9.5

• expression analysis indicates reduced populations of both mesodermal and neural crest cells

abnormal embryo development ( J:41809 )

• at E8.75 defects are seen in the anterior end of the embryo including the region of the heart; however, development posterior to the heart is normal

• variable severity of the defects at E9.0 - E9.5

abnormal dorsal-ventral axis patterning ( J:41809 )

• at E9.0 - E9.5 dorsal-ventral patterning of the forebrain is abnormal

• at E9.0 - E9.5 in severely affected embryos expression analysis indicates ventral expansion of dorsal cell fates in floor plate cells with resulting loss of ventral structures

• however, anterior-posterior patterning of the neural tube is unaffected

embryonic growth arrest ( J:41809 )

• arrest around the 20 - 25 somite stage

embryonic growth retardation ( J:41809 )

• at E9.0 - E9.5

abnormal neural tube morphology ( J:41809 )

• at E9.5 in severely affected embryos the floor and roof of the neural tube are in contact with each other at the diencephalic-mesencephalic junction

• at E9.0 - E9.5 in severely affected embryos expression analysis indicates ventral expansion of dorsal cell fates in floor plate cells with resulting loss of ventral structures

• however, anterior-posterior patterning of the neural tube is unaffected

decreased embryonic neuroepithelium thickness ( J:41809 )

• at E9.5 in less severely affected embryos thinning of the neuroepithelium is seen in the forebrain, hindbrain, and spinal cord

• reduction in neuroepithelium is most severe in the forebrain

abnormal notochord morphology ( J:41809 )

• in severely affected embryos notochord cells disappear from the rostral half of the embryo by E9.5

• however, in less severely affected embryos notochord cells are maintained

decreased somite size ( J:41809 )

• reduced in size at E9.0 - E9.5

cardiovascular system

abnormal dorsal aorta morphology ( J:41809 )

• at E9.5 the dorsal aorta is elongated, enlarged, or disorganized

abnormal first pharyngeal arch artery morphology ( J:41809 )

• the first branchial arch arteries are either not visible or poorly formed

abnormal anterior cardinal vein morphology ( J:41809 )

• greatly enlarged anterior cardinal veins at E9.5

abnormal heart development ( J:41809 )

• by E9.5, the dorsal mesocardium fails to form resulting in connection of the heart to the gut

abnormal heart looping ( J:41809 )

• defects in heart looping are seen at E8.75

• at E9.5 the heart is a straight or S-shaped tube at the midline

absent dorsal mesocardium ( J:41809 )

• the dorsal mesocardium fails to form

vision/eye

abnormal optic vesicle formation ( J:41809 )

• smaller at E9.5 in less severely affected embryos

absent optic vesicle ( J:41809 )

• at E9.5 in more severely affected embryos the optic vesicle is lost as a result of lack of maintenance as optic vesicles are present at E8.75

nervous system

abnormal neural tube morphology ( J:41809 )

• at E9.5 in severely affected embryos the floor and roof of the neural tube are in contact with each other at the diencephalic-mesencephalic junction

• at E9.0 - E9.5 in severely affected embryos expression analysis indicates ventral expansion of dorsal cell fates in floor plate cells with resulting loss of ventral structures

• however, anterior-posterior patterning of the neural tube is unaffected

decreased embryonic neuroepithelium thickness ( J:41809 )

• at E9.5 in less severely affected embryos thinning of the neuroepithelium is seen in the forebrain, hindbrain, and spinal cord

• reduction in neuroepithelium is most severe in the forebrain

abnormal brain morphology ( J:41809 )

abnormal forebrain development ( J:41809 )

• dorsal-ventral patterning is abnormal

decreased forebrain size ( J:41809 )

• dramatically reduced at E8.75

decreased hindbrain size ( J:41809 )

• reduced in size at E9.0 - E9.5

decreased spinal cord size ( J:41809 )

• at E9.0 - E9.5

respiratory system

abnormal pharynx morphology ( J:41809 )

• smaller and abnormally shaped

small pharynx ( J:41809 )

growth/size/body

embryonic growth retardation ( J:41809 )

• at E9.0 - E9.5

craniofacial

abnormal pharyngeal arch morphology ( J:41809 )

• abnormal at E8.75

abnormal first pharyngeal arch morphology ( J:41809 )

• pyknotic cells are seen in the mesenchyme of the first branchial arches

• the first branchial arch arteries are either not visible or poorly formed

• epithelium of the first arch fails to fuse ventrally with the pharyngeal endoderm

abnormal first pharyngeal arch artery morphology ( J:41809 )

• the first branchial arch arteries are either not visible or poorly formed

small first pharyngeal arch ( J:41809 )

• at E9.5

• expression analysis indicates reduced populations of both mesodermal and neural crest cells

abnormal second pharyngeal arch morphology ( J:41809 )

• pyknotic cells are seen in the mesenchyme of the second branchial arches

small second pharyngeal arch ( J:41809 )

• at E9.5

• expression analysis indicates reduced populations of both mesodermal and neural crest cells

Genotype
MGI:6393316

cx16

• Allelic Composition: 9030622O22Rik^em1Eem/9030622O22Rik⁺; Foxa2^tm1.1Khk/Foxa2⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1

immune system

respiratory system inflammation ( J:284174 )

• by 8-12 weeks of age, mice exhibit areas of peribronchial and perivascular inflammation, consisting predominantly of B220+ B cells

• inflammation is most notable in the subepithelial region of airway branch points

• CD3e+ T cells are found interspersed among the B cells at foci of inflammation

respiratory system

respiratory system inflammation ( J:284174 )

• by 8-12 weeks of age, mice exhibit areas of peribronchial and perivascular inflammation, consisting predominantly of B220+ B cells

• inflammation is most notable in the subepithelial region of airway branch points

• CD3e+ T cells are found interspersed among the B cells at foci of inflammation

abnormal respiratory mucosa goblet cell morphology ( J:284174 )

• goblet cell metaplasia, with greater numbers of goblet cells than in single Foxa2 heterozygotes

Genotype
MGI:3625856

cx17

• Allelic Composition: Foxa2^tm1Jrt/Foxa2⁺; Nodal^tm1Rob/Nodal⁺
• Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ

embryo

abnormal direction of embryo turning ( J:32935 )

• in embryos with loss of left-right asymmetry in Nodal expression the direction of turning is randomized

delayed embryo turning ( J:32935 )

• seen in all embryos

growth/size/body

situs ambiguus ( J:32935 )

• in 7 of 10 mutants the positioning of the abdominal viscera and heart is abnormal