Phenotypes associated with this allele

• Allele Symbol: Hoxd⁺
• Allele Name: wild type
• Allele ID: MGI:1857662
• Summary: 9 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Hoxd^tm5Ddu/Hoxd^+	involves: 129S2/SvPas	MGI:3721599
ht2	Hoxd^tm21(Hoxd11)Ddu/Hoxd^+	involves: 129S2/SvPas	MGI:3810764
ht3	Hoxd^tm21(Hoxd11)Ddu/Hoxd^+	involves: 129S2/SvPas * C57BL/6 * CBA	MGI:5508536
ht4	Hoxd^tm12Ddu/Hoxd^+	involves: 129S2/SvPas * C57BL/6 * DBA/2	MGI:3690718
cx5	Hoxa^tm1.1Ssp/Hoxa^+ Hoxd^tm1.1Ssp/Hoxd^+	involves: 129 * CD-1	MGI:5522978
cx6	Hoxa^tm1.1Ssp/Hoxa^tm1.1Ssp Hoxd^tm1.1Ssp/Hoxd^+	involves: 129 * CD-1	MGI:5522980
cx7	Hoxd^tm11Ddu/Hoxd^+ Tg(Hoxd9/lacZ/neo)4Ddu/0	involves: 129S2/SvPas	MGI:4361583
cx8	Hoxa11^tm1Ssp/Hoxa11^+ Hoxd^tm3Ddu/Hoxd^+	involves: 129S2/SvPas * C57BL/6 * CF-1 * SJL	MGI:2178137
cx9	Del(2Hoxd11-Hoxd13)29Ddu/Hoxd^tm3Ddu	involves: 129S2/SvPas * C57BL/6 * SJL	MGI:2178141

Genotype
MGI:3721599

ht1

• Allelic Composition: Hoxd^tm5Ddu/Hoxd⁺
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

decreased lumbar vertebrae number ( J:45706 )

• 6 of 25 mice exhibit an L5 configuration instead of the L6 configuration found in wild-type mice

Genotype
MGI:3810764

ht2

• Allelic Composition: Hoxd^{tm21(Hoxd11)Ddu}/Hoxd⁺
• Genetic Background: involves: 129S2/SvPas

renal/urinary system

dilated renal tubule ( J:131874 )

• in 50% of mice

Genotype
MGI:5508536

ht3

• Allelic Composition: Hoxd^{tm21(Hoxd11)Ddu}/Hoxd⁺
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

behavior/neurological

behavior/neurological phenotype ( J:199759 )

N • female mice exhibit normal courting behavior

Genotype
MGI:3690718

ht4

• Allelic Composition: Hoxd^tm12Ddu/Hoxd⁺
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

mortality/aging

prenatal lethality ( J:91567 )

embryo

abnormal rostral-caudal axis patterning ( J:91567 )

• anterior ectopic expression of Hoxd11 and Hoxd13

Genotype
MGI:5522978

cx5

• Allelic Composition: Hoxa^tm1.1Ssp/Hoxa⁺; Hoxd^tm1.1Ssp/Hoxd⁺
• Genetic Background: involves: 129 * CD-1

reproductive system

abnormal internal female genitalia morphology ( J:198638 )

♀ • often display an elongated uterotubal junction

abnormal vas deferens morphology ( J:198638 )

♂ • show some gross coiling of the anterior vas deferens

female infertility ( J:198638 )

♀ • about 26% of females with a vaginal plug fail to produce pups

reduced female fertility ( J:198638 )

♀ • females that do become pregnant have smaller litters

decreased litter size ( J:198638 )

♀

Genotype
MGI:5522980

cx6

• Allelic Composition: Hoxa^tm1.1Ssp/Hoxa^tm1.1Ssp; Hoxd^tm1.1Ssp/Hoxd⁺
• Genetic Background: involves: 129 * CD-1

reproductive system

abnormal uterus morphology ( J:198638 )

♀ • anteriorization of the uterus is exacerbated compared to mice homozygous for the Hoxa mutation alone

♀ • coiled for nearly half the length

♀ • uteri closely resemble oviducts

♀ • reduction of the stromal layer and an increase in luminal branching

thin myometrium ( J:198638 )

♀

thin uterus ( J:198638 )

♀ • extremely thin

abnormal cauda epididymis morphology ( J:198638 )

♂ • smaller tubules which resemble those in the more anterior caput

♂ • smaller with an extremely thin muscle layer, thinning is more severe than in mice homozygous for the Hoxa mutation alone

small epididymis ( J:198638 )

♂ • smaller caudal epididymis

abnormal vas deferens morphology ( J:198638 )

♂ • significant enhancement of the anteriorization compared to mice homozygous for the Hoxa mutation alone

♂ • extreme coiling from the epididymal junction extending posterior for approximately one-third of the length

♂ • resembles the wild-type caudal epididymis with thinner muscle and stromal layers

female infertility ( J:198638 )

♀

male infertility ( J:198638 )

♂

Genotype
MGI:4361583

cx7

• Allelic Composition: Hoxd^tm11Ddu/Hoxd⁺; Tg(Hoxd9/lacZ/neo)4Ddu/0
• Genetic Background: involves: 129S2/SvPas

limbs/digits/tail

abnormal digit morphology ( J:82850 )

• some mice carrying both mutant loci in trans lack the joint between P1 and P2 in digit III

• all forelimbs of mice carrying both mutant loci in trans exhibit a supernumerary postaxial bony element

abnormal phalanx morphology ( J:82850 )

• mice carrying both mutant loci in trans show loss of phalange 2 in digit II

• most mice carrying both mutant loci in trans lose phalange 2 in digit V

abnormal metatarsal bone morphology ( J:82850 )

• the first metatarsal of hindlimbs is dysmorphic in mice carrying both mutant loci in trans, with an aberrantly thick and shorter aspect, and is occasionally fused to P1

skeleton

abnormal phalanx morphology ( J:82850 )

• mice carrying both mutant loci in trans show loss of phalange 2 in digit II

• most mice carrying both mutant loci in trans lose phalange 2 in digit V

abnormal metatarsal bone morphology ( J:82850 )

• the first metatarsal of hindlimbs is dysmorphic in mice carrying both mutant loci in trans, with an aberrantly thick and shorter aspect, and is occasionally fused to P1

Genotype
MGI:2178137

cx8

• Allelic Composition: Hoxa11^tm1Ssp/Hoxa11⁺; Hoxd^tm3Ddu/Hoxd⁺
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * CF-1 * SJL

skeleton

skeleton phenotype ( J:47900 )

N • normal morphology of the ulna, radius, tibia, and fibula

Genotype
MGI:2178141

cx9

• Allelic Composition: Del(2Hoxd11-Hoxd13)29Ddu/Hoxd^tm3Ddu
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

limbs/digits/tail

abnormal digit morphology ( J:47900 )

• reductions in size of digits II and V

polydactyly ( J:47900 )