Del(2Hoxd1-Hoxd13)1Ddu
Targeted Allele Detail
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Symbol: |
Del(2Hoxd1-Hoxd13)1Ddu |
Name: |
deletion, Chr 2, Denis Duboule 1 |
MGI ID: |
MGI:3616018 |
Synonyms: |
del(1-13), Del1Ddu, TgH(d11/lac/Del9)Ge |
Gene: |
Del(2Hoxd1-Hoxd13)1Ddu Location: Chr2:74498654-74595486 bp Genetic Position: Chr2, Syntenic
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Germline Transmission: |
Earliest citation of germline transmission:
J:70547
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Parent Cell Line: |
D3 (ES Cell)
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Strain of Origin: |
129S2/SvPas
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Intergenic deletion, Intragenic deletion
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Del(2Hoxd1-Hoxd13)1Ddu involves 16 genes/genome features (Hoxd13, Hoxd12, Hoxd11 ...)
View all
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Mutation details: This allele was created in the same ES cells used to create Hoxdtm2Ddu and thus has a loxP site located 5' of Hoxd13. A lacZ reporter sequence followed by a PGKneo selection cassette was inserted into exon 2. In vitro cre expression removed the entire Hoxd cluster replacing it with a Hoxd11/lacZ fusion gene.
(J:70547)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Del(2Hoxd1-Hoxd13)1Ddu Mutation: |
0 strains or lines available
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Original: |
J:70547 Zakany J, et al., Localized and transient transcription of Hox genes suggests a link between patterning and the segmentation clock. Cell. 2001 Jul 27;106(2):207-17 |
All: |
17 reference(s) |
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