Hoxd^tm12Ddu
Targeted Allele Detail

Summary

• Symbol: Hoxd^tm12Ddu
• Name: homeobox D cluster; targeted mutation 12, Denis Duboule
• MGI ID: MGI:3051374
• Gene: Hoxd Location: unknown Genetic Position: Chr2, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91567
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted
• Mutation: Inversion
• Hoxd^tm12Ddu involves 13 genes/genome features (Hoxd13, Hoxd12, Hoxd11 ...) View all
• Mutation details: This allele involved the use of an embryonic stem cell line with a Hoxd11/lac/loxP reporter gene inserted 5' of Hoxd13. A floxed neo was inserted 3' to the Hoxd1 gene in the reverse orientation. Crossing with mice in which Cre is expressed in the germ line excised the neo and reversed the orientation of the larger floxed sequence. (J:91567)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxd Mutation: 0 strains or lines available

Notes

Mutant mice were generated from TgH[d11/lac]Ge cells (the targeted D3 ES cells).

References

• Original: J:91567 Zakany J, et al., A dual role for Hox genes in limb anterior-posterior asymmetry. Science. 2004 Jun 11;304(5677):1669-72
• All: 1 reference(s)