Phenotypes associated with this allele

• Allele Symbol: Bmi1⁺
• Allele Name: wild type
• Allele ID: MGI:1857636
• Summary: 10 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Bmi1^tm1.1(KOMP)Vlcg/Bmi1^+	C57BL/6N-Bmi1^tm1.1(KOMP)Vlcg/MbpMmucd	MGI:6325116
ht2	Bmi1^tm1Brn/Bmi1^+	involves: 129P2/OlaHsd	MGI:2674271
ht3	Bmi1^tm1Ilw/Bmi1^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3806981
ht4	Bmi1^tm2Ilw/Bmi1^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3806982
cn5	Bmi1^tm1(cre/ERT)Mrc/Bmi1^+ Ctnnb1^tm1Mmt/Ctnnb1^+	involves: 129S1/Sv * 129X1/SvJ	MGI:3805821
cn6	Bmi1^tm1(cre/ERT)Mrc/Bmi1^+ Gt(ROSA)26Sor^tm1(DTA)Mrc/Gt(ROSA)26Sor^+	involves: 129S1/Sv * 129X1/SvJ	MGI:3805820
cn7	Gt(ROSA)26Sor^tm4(EWSR1/ATF1)Mrc/Gt(ROSA)26Sor^+ Bmi1^tm1(cre/ERT)Mrc/Bmi1^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5495321
cx8	Pcgf2^tm1Hko/Pcgf2^tm1Hko Bmi1^tm1Brn/Bmi1^+	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3577617
cx9	Bmi1^tm1Brn/Bmi1^+ E2f6^tm1Lees/E2f6^tm1Lees	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6	MGI:3790811
cx10	Bmi1^tm1Brn/Bmi1^+ E2f6^tm1Lees/E2f6^+	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6	MGI:3790812

Genotype
MGI:6325116

ht1

• Allelic Composition: Bmi1^{tm1.1(KOMP)Vlcg}/Bmi1⁺
• Genetic Background: C57BL/6N-Bmi1^{tm1.1(KOMP)Vlcg}/MbpMmucd
• Cell Lines: 12981A-D5

Data Sources

IMPC Data for Bmi1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

abnormal embryo size ( J:211773 )

♀

IMPC - TCP

growth/size/body

abnormal embryo size ( J:211773 )

♀

IMPC - TCP

homeostasis/metabolism

edema ( J:211773 )

IMPC - TCP

vision/eye

anophthalmia ( J:211773 )

♀

IMPC - TCP

Genotype
MGI:2674271

ht2

• Allelic Composition: Bmi1^tm1Brn/Bmi1⁺
• Genetic Background: involves: 129P2/OlaHsd

skeleton

thoracic vertebral transformation ( J:134271 )

• transformation of T13 to L1 is seen in 13% of heterozygous mice

cervical vertebral transformation ( J:134271 )

• partial or complete transformation of C7 to T1 is seen in 31% and 19% of heterozygous mice, respectively

lumbar vertebral transformation ( J:134271 )

• transformation of L6 to S1 is seen in 50% of heterozygous mice

Genotype
MGI:3806981

ht3

• Allelic Composition: Bmi1^tm1Ilw/Bmi1⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

normal phenotype

no abnormal phenotype detected ( J:138039 )

• mice are indistinguishable from wild-type mice

Genotype
MGI:3806982

ht4

• Allelic Composition: Bmi1^tm2Ilw/Bmi1⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

normal phenotype

no abnormal phenotype detected ( J:138039 )

• mice are indistinguishable from wild-type mice

Genotype
MGI:3805821

cn5

• Allelic Composition: Bmi1^{tm1(cre/ERT)Mrc}/Bmi1⁺; Ctnnb1^tm1Mmt/Ctnnb1⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

mortality/aging

premature death ( J:138364 )

• mice die 50 days following administration of tamoxifen

neoplasm

increased intestinal adenoma incidence ( J:138364 )

• beginning 22 days following administration of tamoxifen

digestive/alimentary system

abnormal crypts of Lieberkuhn morphology ( J:138364 )

• the number of proliferating cells within crypts is increased 15 days following administration of tamoxifen

increased intestinal adenoma incidence ( J:138364 )

• beginning 22 days following administration of tamoxifen

endocrine/exocrine glands

abnormal crypts of Lieberkuhn morphology ( J:138364 )

• the number of proliferating cells within crypts is increased 15 days following administration of tamoxifen

Genotype
MGI:3805820

cn6

• Allelic Composition: Bmi1^{tm1(cre/ERT)Mrc}/Bmi1⁺; Gt(ROSA)26Sor^tm1(DTA)Mrc/Gt(ROSA)26Sor⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

mortality/aging

premature death ( J:138364 )

• mice die 2 to 3 days following administration of tamoxifen for three consecutive days after weaning

digestive/alimentary system

abnormal duodenum crypts of Lieberkuhn morphology ( J:138364 )

• following administration of one dose of tamoxifen after weaning, mice exhibit areas of the duodenum that are devoid of crypt cells

• however, crypt cells recover by 9 months of age

abnormal jejunum crypts of Lieberkuhn morphology ( J:138364 )

• following administration of one dose of tamoxifen after weaning, mice exhibit areas of the jejunum that are devoid of crypt cells

• however, crypt cells recover by 9 months of age

growth/size/body

slow postnatal weight gain ( J:138364 )

• following administration of one dose of tamoxifen after weaning

• however, normal weight is recovered by 9 months of age

endocrine/exocrine glands

abnormal duodenum crypts of Lieberkuhn morphology ( J:138364 )

• following administration of one dose of tamoxifen after weaning, mice exhibit areas of the duodenum that are devoid of crypt cells

• however, crypt cells recover by 9 months of age

abnormal jejunum crypts of Lieberkuhn morphology ( J:138364 )

• following administration of one dose of tamoxifen after weaning, mice exhibit areas of the jejunum that are devoid of crypt cells

• however, crypt cells recover by 9 months of age

Genotype
MGI:5495321

cn7

• Allelic Composition: Gt(ROSA)26Sor^{tm4(EWSR1/ATF1)Mrc}/Gt(ROSA)26Sor⁺; Bmi1^{tm1(cre/ERT)Mrc}/Bmi1⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

neoplasm

increased tumor incidence ( J:194308 )

• fully penetrant tumorigenesis when tamoxifen is injected after 3 weeks of age

• tumors in deep mesenchymal tissues of the limbs and trunk

• most tumors form adjacent to bone but some are totally in muscle

• all tumors with "clear cell" morphology

Genotype
MGI:3577617

cx8

• Allelic Composition: Pcgf2^tm1Hko/Pcgf2^tm1Hko; Bmi1^tm1Brn/Bmi1⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

craniofacial

abnormal craniofacial bone morphology ( J:68216 )

split exoccipital bone ( J:68216 )

cleft secondary palate ( J:68216 )

skeleton

abnormal scapula morphology ( J:68216 )

acromion hypoplasia ( J:68216 )

• acromion is poorly formed

scapular bone foramen ( J:68216 )

• holes are seen in the blade of the scapula

abnormal axial skeleton morphology ( J:68216 )

abnormal craniofacial bone morphology ( J:68216 )

split exoccipital bone ( J:68216 )

abnormal rib joint morphology ( J:68216 )

• rudimentary ribs attached to C6

abnormal cervical atlas morphology ( J:68216 )

• atlas resembles the third cervical vertebra

cervical vertebral transformation ( J:68216 )

• atlas resembles the third cervical vertebra

abnormal sternum ossification ( J:68216 )

• ectopic ossification centers in sternum

digestive/alimentary system

cleft secondary palate ( J:68216 )

growth/size/body

cleft secondary palate ( J:68216 )

Genotype
MGI:3790811

cx9

• Allelic Composition: Bmi1^tm1Brn/Bmi1⁺; E2f6^tm1Lees/E2f6^tm1Lees
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

skeleton

thoracic vertebral transformation ( J:134271 )

• transformation of T13 to L1 is seen in 77% of compound mutant mice

cervical vertebral transformation ( J:134271 )

• partial or complete transformation of C7 to T1 is seen in 27% and 4% of compound mutant mice, respectively

lumbar vertebral transformation ( J:134271 )

• transformation of L6 to S1 is seen in 92% of compound mutant mice

Genotype
MGI:3790812

cx10

• Allelic Composition: Bmi1^tm1Brn/Bmi1⁺; E2f6^tm1Lees/E2f6⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

skeleton

thoracic vertebral transformation ( J:134271 )

• transformation of T7 to T8 and T13 to L1 are seen in 4% and 50% of double heterozygous mice, respectively

cervical vertebral transformation ( J:134271 )

• partial or complete transformation of C7 to T1 is seen in 42% and 8% of double heterozygous mice, respectively

• transformation of C5 to C6 is seen in 4% of double heterozygous mice

lumbar vertebral transformation ( J:134271 )

• transformation of L6 to S1 is seen in 73% of double heterozygous mice