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Targeted Allele Detail
Symbol: Bmi1tm1Brn
Name: Bmi1 polycomb ring finger oncogene; targeted mutation 1, Anton Berns
MGI ID: MGI:1857632
Synonyms: bmi-1-, Bmi1-
Gene: Bmi1  Location: Chr2:18681829-18691440 bp, + strand  Genetic Position: Chr2, 12.9 cM
Alliance: Bmi1tm1Brn page
Germline Transmission:  Earliest citation of germline transmission: J:17712
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe sequences encoding the ATG start codon, the zinc finger motif, and part of the helix-turn-helix motif were replaced either with a hygromycin-resistance cassette or one that conveyed neomycin-resistance. (J:17712)
Inheritance:    Semidominant
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 126 assay results
In Structures Affected by this Mutation: 27 anatomical structures
Tumor Data
List all tumor models in MMHCdb carrying Bmi1tm1Brn
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Bmi1 Mutation:  26 strains or lines available
Original:  J:17712 van der Lugt NM, et al., Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene. Genes Dev. 1994 Apr 1;8(7):757-69
All:  84 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory