Analysis Tools
mortality/aging
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• homozygotes die between E12.5 and term
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cardiovascular system
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• at E15.5, 2 out of 6 homozygotes display extremely thin ventricular walls along with a swollen heart and a rounded apex, while 3 out of 6 mutants show thin ventricular walls in the absence of swelling; the remaining one homozygote displays a morphologically normal heart
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• at E15.5, homozygotes display a thin ventricular myocardium relative to wild-type mice
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small heart
(
J:42943
)
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• at E10.5-E13.5, mutant hearts appear to be smaller than wild-type hearts
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• at E15.5, 5 out of 6 homozygotes exhibit thin ventricular walls, in the absence of ventricular septal defects
• no significant differences in ventricular wall thickness are observed at E11.5 and E13.5
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• at E15.5, mutant hearts display insufficient cardiomyocyte proliferation, in the absence of abnormal cell differentiation or cell death
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embryo
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• at E10.5-E13.5, homozygous embryos appear to be shorter than wild-type embryos
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growth/size/body
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• at E10.5-E13.5, homozygous embryos appear to be shorter than wild-type embryos
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nervous system
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• at E11.5 and E12.5, homozygotes exhibit a significantly increased apoptosis of motoneurons in the ventral horn of lower medulla and the upper cervical spinal cord
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muscle
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• at E15.5, homozygotes display a thin ventricular myocardium relative to wild-type mice
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• at E15.5, mutant hearts display insufficient cardiomyocyte proliferation, in the absence of abnormal cell differentiation or cell death
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hematopoietic system
| N |
• at E12.5, homozygotes exhibit neither anemia nor abnormal red blood cells in peripheral blood vessels
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liver/biliary system
| N |
• at E12.5, homozygotes display a histologically normal liver relative to wild-type mice
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cellular
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• at E15.5, mutant hearts display insufficient cardiomyocyte proliferation, in the absence of abnormal cell differentiation or cell death
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• at E11.5 and E12.5, homozygotes exhibit a significantly increased apoptosis of motoneurons in the ventral horn of lower medulla and the upper cervical spinal cord
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