All Phenotypes Wld<s> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Wld^s/Wld^s	C57BL/6Ola-Wld^s	MGI:4438866
cx2	Cmtm5^{tm1d(KOMP)Wtsi}/Cmtm5^{tm1d(KOMP)Wtsi} Wld^s/+	B6(Cg)-Wld^s Cmtm5^{tm1d(KOMP)Wtsi}	MGI:7331615
cx3	Nmnat2^{Gt(EUCE0262a08)Hmgu}/Nmnat2^{Gt(EUCE0262a08)Hmgu} Wld^s/+	involves: 129P2/OlaHsd * C57BL/6J * C57BL/6Ola	MGI:5543591
cx4	Nmnat2^{Gt(EUCE0262a08)Hmgu}/Nmnat2^{Gt(EUCE0262a08)Hmgu} Wld^s/Wld^s	involves: 129P2/OlaHsd * C57BL/6J * C57BL/6Ola	MGI:5543592
cx5	Tg(SOD1*G93A)1Gur/0 Wld^s/Wld^s	involves: C57BL/6J * C57BL/6Ola * SJL/J	MGI:4835779
cx6	Tg(SOD1*G93A)1Gur/0 Wld^s/+	involves: C57BL/6J * C57BL/6Ola * SJL/J	MGI:4835781

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

slow Wallerian degeneration ( J:3359 , J:15229 , J:19950 , J:19951 )

• 1 year old C57BL/Ola mice showed faster Wallerian degeneration than 4 week old mice, with compund action potentials recorded in a distal nerve stump 5 days after section in 4 week old mutant mice, but not 1 year old mutant mice (J:3359)

• following optic nerve transection, the axons of retinal ganglion cells undergo very slow Wallerian degeneration (J:19950)

• 5 days after severing the sciatic nerve, mice show slow Wallerian degeneration evidenced by an intact cytoskeleton and plasma membrane, while control mice show a destruction of cytoarchitecture in the distal portion of the severed nerve (J:19951)

• in addition, the distal portions of mutant severed nerves show an ability to conduct action potentials up to 14 days post section, while control nerves stop conducting 2 days after the nerve is cut (J:19951)

• invasion by polymorphs and macrophages of the distal portion of the severed nerve is not observed in mutant mice, resulting in an absence of myelin breakdown; controls show an increase in myeloperoxidase positive cells and Schwann cell proliferation within 3 days of section (J:19951)

retina ganglion cell degeneration ( J:19950 )

• while retinal ganglion cells undergo retrograde degeneration in response to optic nerve injury, they do so at a much slower rate than in other strains

abnormal peripheral nervous system regeneration ( J:12834 )

• the rate of regeneration and recovery of function after sciatic nerve crush is incomplete compared to C57BL/6J mice, as determined by sciatic functional index (SFI) using measurements of walking ability and by measurements of axonal transport

delayed peripheral nervous system regeneration ( J:12834 , J:19951 )

• the rate of regeneration and recovery of function after sciatic nerve crush is delayed compared to C57BL/6J mice, as determined by SFI using measurments of walking ability and by measurements of axonal transport (J:12834)

• the rate of regeneration and recovery of function after facial nerve crush is delayed compared to C57BL/6J mice, as observed by vibrissae movement (J:12834)

• the rate of regeneration and recovery of motor function in the soleus muscle after a crush of the sciatic nerve is similar in mutant mice and controls, with a slight delay in recovery of normal conduction velocity in mutant mice (J:19951)

vision/eye

retina ganglion cell degeneration ( J:19950 )

• while retinal ganglion cells undergo retrograde degeneration in response to optic nerve injury, they do so at a much slower rate than in other strains

homeostasis/metabolism

slow Wallerian degeneration ( J:3359 , J:15229 , J:19950 , J:19951 )

• following optic nerve transection, the axons of retinal ganglion cells undergo very slow Wallerian degeneration (J:19950)

Allelic Composition	Cmtm5^{tm1d(KOMP)Wtsi}/Cmtm5^{tm1d(KOMP)Wtsi} Wld^s/+
Genetic Background	B6(Cg)-Wld^s Cmtm5^{tm1d(KOMP)Wtsi}

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cmtm5^{tm1d(KOMP)Wtsi} mutation (0 available); any Cmtm5 mutation (17 available)
Wld^s mutation (1 available); any Wld mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal axon morphology ( J:327261 )

• mice show reduced number of pathologically appearing axons in optic nerves at 6 months of age compared to homozygous Cmtm5^{tm1d(KOMP)Wtsi} mice but still increased number compared to wild-type mice

Allelic Composition	Nmnat2^{Gt(EUCE0262a08)Hmgu}/Nmnat2^{Gt(EUCE0262a08)Hmgu} Wld^s/+
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * C57BL/6Ola

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nmnat2^{Gt(EUCE0262a08)Hmgu} mutation (0 available); any Nmnat2 mutation (270 available)
Wld^s mutation (1 available); any Wld mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:200901 )

• die within a few hours of birth

• unlike Nmnat2 single mutants, double mutants initiate breathing in most cases

behavior/neurological

behavior/neurological phenotype ( J:200901 )

N	• unlike Nmnat2 single mutants, double mutants do not display a hunched posture

muscle

muscle phenotype ( J:200901 )

N	• unlike Nmnat2 single mutants, muscle mass and diaphragm morphology are similar to controls in double mutants

nervous system

nervous system phenotype ( J:200901 )

• at E14.5 intercostal and hindlimb nerves show a grossly normal morphology and loss of dorsal root ganglia cells and spinal cord motor neurons later in development is largely prevented, unlike in Nmnat2 single mutants

• the optic nerve and olfactory bulb defects in single Nmnat2 single mutants are largely rescued in double mutants

renal/urinary system

renal/urinary system phenotype ( J:200901 )

N	• unlike Nmnat2 single mutants, double mutants do not display a distended bladder

Allelic Composition	Nmnat2^{Gt(EUCE0262a08)Hmgu}/Nmnat2^{Gt(EUCE0262a08)Hmgu} Wld^s/Wld^s
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * C57BL/6Ola

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:200901 )

• double homozygous mice survive to breeding age without overt signs of abnormality and are fertile

Allelic Composition	Tg(SOD1*G93A)1Gur/0 Wld^s/Wld^s
Genetic Background	involves: C57BL/6J * C57BL/6Ola * SJL/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(SOD1*G93A)1Gur mutation (4 available)
Wld^s mutation (1 available); any Wld mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:105092 )

• prolonged survival (140.335 vs. 131.13.7 days), compare with Tg(SOD1*G93A)1Gur mice

• female mice survive longer than the male (1455.1 vs. 1355.5 days)

Allelic Composition	Tg(SOD1*G93A)1Gur/0 Wld^s/+
Genetic Background	involves: C57BL/6J * C57BL/6Ola * SJL/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(SOD1*G93A)1Gur mutation (4 available)
Wld^s mutation (1 available); any Wld mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:105092 )

• prolonged survival (141.98.9 vs. 131.13.7 days), compare with Tg(SOD1*G93A)1Gur mice

• female mice survive longer than the male (145.48.2 vs. 137.67.9 days)

nervous system

slow Wallerian degeneration ( J:105092 )

• 5 days after sciatic nerve transection, mice show delayed Wallerian degeneration, while Tg(SOD1*G93A)1Gur mice show a loss of axons and presence of myelin ovoids and phagocytes

abnormal motor neuron innervation pattern ( J:105092 )

• delayed denervation at the neuromuscular junction

• more axons and innervated neuromuscular junctions in nerve roots than Tg(SOD1*G93A)1Gur mutants at day 80

decreased motor neuron number ( J:105092 )

• similar levels of ventral root axon loss to that seen in Tg(SOD1*G93A)1Gur mice

decreased sensory neuron number ( J:105092 )

• similar levels of dorsal root axon loss to that seen in Tg(SOD1*G93A)1Gur mice

homeostasis/metabolism

slow Wallerian degeneration ( J:105092 )

• 5 days after sciatic nerve transection, mice show delayed Wallerian degeneration, while Tg(SOD1*G93A)1Gur mice show a loss of axons and presence of myelin ovoids and phagocytes

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