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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Syk+
wild type
MGI:1857464
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		SykM2Btlr/Syk+ C57BL/6J-SykM2Btlr MGI:5775071
ht2
 		Syktm1b(EUCOMM)Hmgu/Syk+ C57BL/6N-Syktm1b(EUCOMM)Hmgu/Ieg MGI:6263619


Genotype
MGI:5775071
ht1
Allelic
Composition		 SykM2Btlr/Syk+
Genetic
Background		 C57BL/6J-SykM2Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
SykM2Btlr mutation (0 available); any Syk mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal NK cell differentiation ( J:231803 )
• increased frequencies of natural killer cells in the peripheral blood
decreased inflammatory response ( J:231803 )
• in response to priming with lipopolysaccharide (LPS) followed by nigericin treatment

hematopoietic system
abnormal NK cell differentiation ( J:231803 )
• increased frequencies of natural killer cells in the peripheral blood




Genotype
MGI:6263619
ht2
Allelic
Composition		 Syktm1b(EUCOMM)Hmgu/Syk+
Genetic
Background		 C57BL/6N-Syktm1b(EUCOMM)Hmgu/Ieg
Cell Lines HEPD0722_4_A07
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Syktm1b(EUCOMM)Hmgu mutation (1 available); any Syk mutation (45 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
adipose tissue

behavior/neurological

growth/size/body
decreased lean body mass ( J:211773 )
IMPC - HMGU




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory