Syk^M2Btlr
Chemically induced Allele Detail

Summary

• Symbol: Syk^M2Btlr
• Name: spleen tyrosine kinase; mutation 2, Bruce Beutler
• MGI ID: MGI:5775011
• Synonyms: Sisyphus
• Gene: Syk Location: Chr13:52737209-52802828 bp, + strand Genetic Position: Chr13, 27.41 cM, cytoband B-C2
• Alliance: Syk^M2Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced A to G transition at base pair 52,640,790 (v38) on chromosome 13, or base pair 59,535 in the GenBank genomic region NC_000079. The mutation corresponds to residue 1,775 in the mRNA sequence NM_011518 within exon 11 of 14 total exons and residue 1,771 in the mRNA sequence NM_001198977 within exon 11 of 14 total exons. The mutation results in a tyrosine (Y) to cysteine (C) substitution at position 520 (Y520C). (J:231803)
• Inheritance: Dominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Syk Mutation: 42 strains or lines available

References

• Original: J:231803 SoRelle J, et al., Mutagenetix entry for Sisyphus. MGI Direct Data Submission. 2016
• All: 1 reference(s)