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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		SykM2Btlr
mutation 2, Bruce Beutler
MGI:5775011
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		SykM2Btlr/SykM2Btlr C57BL/6J-SykM2Btlr MGI:5775070
ht2
 		SykM2Btlr/Syk+ C57BL/6J-SykM2Btlr MGI:5775071


Genotype
MGI:5775070
hm1
Allelic
Composition		 SykM2Btlr/SykM2Btlr
Genetic
Background		 C57BL/6J-SykM2Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
SykM2Btlr mutation (0 available); any Syk mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal NK cell differentiation ( J:231803 )
• increased frequencies of natural killer cells in the peripheral blood
decreased inflammatory response ( J:231803 )
• in response to priming with lipopolysaccharide (LPS) followed by nigericin treatment

hematopoietic system
abnormal NK cell differentiation ( J:231803 )
• increased frequencies of natural killer cells in the peripheral blood




Genotype
MGI:5775071
ht2
Allelic
Composition		 SykM2Btlr/Syk+
Genetic
Background		 C57BL/6J-SykM2Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
SykM2Btlr mutation (0 available); any Syk mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal NK cell differentiation ( J:231803 )
• increased frequencies of natural killer cells in the peripheral blood
decreased inflammatory response ( J:231803 )
• in response to priming with lipopolysaccharide (LPS) followed by nigericin treatment

hematopoietic system
abnormal NK cell differentiation ( J:231803 )
• increased frequencies of natural killer cells in the peripheral blood




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory