All Phenotypes Ptgs1<tm1Unc> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ptgs1^tm1Unc/Ptgs1^tm1Unc	B6.129P2-Ptgs1^tm1Unc	MGI:4366288
hm2	Ptgs1^tm1Unc/Ptgs1^tm1Unc	B6;129P2-Ptgs1^tm1Unc/Tac	MGI:4366286
hm3	Ptgs1^tm1Unc/Ptgs1^tm1Unc	involves: 129P2/OlaHsd	MGI:4366245
hm4	Ptgs1^tm1Unc/Ptgs1^tm1Unc	involves: 129P2/OlaHsd * C57BL/6	MGI:2177807
hm5	Ptgs1^tm1Unc/Ptgs1^tm1Unc	involves: 129P2/OlaHsd * C57BL/6 * CD-1	MGI:3812359
hm6	Ptgs1^tm1Unc/Ptgs1^tm1Unc	involves: 129P2/OlaHsd * C57BL/6 * DBA/1	MGI:4366280
hm7	Ptgs1^tm1Unc/Ptgs1^tm1Unc	involves: 129P2/OlaHsd * C57BL/6 * DBA/2	MGI:3620784
hm8	Ptgs1^tm1Unc/Ptgs1^tm1Unc	involves: 129P2/OlaHsd * C57BL/6J	MGI:4366165
hm9	Ptgs1^tm1Unc/Ptgs1^tm1Unc	involves: 129/Sv * 129P2/OlaHsd * C57BL/6	MGI:4366243
ht10	Ptgs1^tm1Unc/Ptgs1⁺	D1.129P2-Ptgs1^tm1Unc	MGI:4366268
ht11	Ptgs1^tm1Unc/Ptgs1⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:3603422
ht12	Ptgs1^tm1Unc/Ptgs1⁺	involves: 129P2/OlaHsd * C57BL/6 * DBA/2	MGI:3620786
cx13	Nos3^tm1Plh/Nos3^tm1Plh Ptgs1^tm1Unc/Ptgs1^tm1Unc	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6	MGI:4366436
cx14	Ptgs1^tm1Unc/Ptgs1^tm1Unc Ptgs2^tm1.1Fun/Ptgs2^tm1.1Fun	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6	MGI:3629785
cx15	Ptgs1^tm1Unc/Ptgs1^tm1Unc Oxt^tm1Ljm/Oxt^tm1Ljm	involves: 129P2/OlaHsd * C57BL/6	MGI:3603425
cx16	Ptgs1^tm1Unc/Ptgs1^tm1Unc Ptgs2^tm1Unc/Ptgs2^tm1Unc	involves: 129P2/OlaHsd * C57BL/6 * CD-1	MGI:3812358
cx17	Ptgs1^tm1Unc/Ptgs1⁺ Ptgs2^tm1Unc/Ptgs2⁺	involves: 129P2/OlaHsd * C57BL/6J	MGI:3812385
cx18	Ptgs1^tm1Unc/Ptgs1^tm1Unc Ptgs2^tm1Unc/Ptgs2⁺	involves: 129P2/OlaHsd * C57BL/6J	MGI:3812386
cx19	Apc^Min/Apc⁺ Ptgs1^tm1Unc/Ptgs1^tm1Unc	involves: 129P2/OlaHsd * C57BL/6J	MGI:4366247
cx20	Ptgs1^tm1Unc/Ptgs1⁺ Ptgs2^tm1Unc/Ptgs2^tm1Unc	involves: 129P2/OlaHsd * C57BL/6J	MGI:3812383
cx21	Ptgs1^tm1Unc/Ptgs1^tm1Unc Ptgs2^tm1Unc/Ptgs2^tm1Unc	involves: 129P2/OlaHsd * C57BL/6J	MGI:3812381
cx22	Apc^Min/Apc⁺ Ptgs1^tm1Unc/Ptgs1⁺	involves: 129P2/OlaHsd * C57BL/6J	MGI:4366248
cx23	Hr^hr/Hr^hr Ptgs1^tm1Unc/Ptgs1⁺	involves: 129P2/OlaHsd * C57BL/6 * SKH1	MGI:4366349
cx24	Cnr1^tm1Zim/Cnr1^tm1Zim Ptgs1^tm1Unc/Ptgs1^tm1Unc	involves: 129/Sv * 129P2/OlaHsd * C57BL/6J	MGI:4366448

Allelic Composition	Ptgs1^tm1Unc/Ptgs1^tm1Unc
Genetic Background	B6.129P2-Ptgs1^tm1Unc

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptgs1^tm1Unc mutation (0 available); any Ptgs1 mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal drinking behavior ( J:125586 )

• after 30 minutes, IL1beta-fed mice fail to exhibit decreased drinking of sweetened mild unlike similarly treated wild-type mice

• however, 90 minutes after IL1beta administration mice exhibit a normal decrease in drinking behavior

abnormal nociception after inflammation ( J:110716 )

• FCA-treated female mice fail to develop contralateral mechanical allodynia unlike similarly treated male and wild-type mice

• however, both male nor female mice develop normal ipsilateral allodynia

• FCA-treated male mice fail to develop thermal hyperalgesia unlike similarly treated female and wild-type mice

allodynia ( J:110716 )

• FCA-treated female mice fail to develop contralateral mechanical allodynia unlike similarly treated male and wild-type mice

• however, both male nor female mice develop normal ipsilateral allodynia

increased thermal nociceptive threshold ( J:110716 )

• FCA-treated male mice fail to develop thermal hyperalgesia unlike similarly treated female and wild-type mice

homeostasis/metabolism

abnormal response/metabolism to endogenous compounds ( J:125586 )

• after 30 minutes, IL1beta-fed mice fail to exhibit decreased drinking of sweetened mild unlike similarly treated wild-type mice

• however, 90 minutes after IL1beta administration mice exhibit a normal decrease in drinking behavior

decreased physiological sensitivity to xenobiotic ( J:115589 )

• SC-560-treated mice fail to exhibit a reduction in cranial blood flow unlike similarly treated wild-type mice

• superoxide dismutase-treated mice fail to exhibit an increase in blood flow caused by bradykinin and A23187 unlike in similarly treated wild-type mice

increased bronchoconstrictive response ( J:141201 )

• mice treated with U46619 or acetylcholine exhibit increased bronchoconstriction compared with similarly treated wild-type mice

• pretreatment with naproxen, diclofenac, or ibuprofen does not increase bronchoconstriction induced by U46619 or acetylcholine unlike in similarly treated wild-type mice

immune system

decreased susceptibility to induced arthritis ( J:110716 )

• FCA-treated female mice exhibit reduced joint destruction and swelling compared with similarly treated male or wild-type mice

cardiovascular system

decreased brain blood flow rate ( J:115589 )

• resting cranial blood flow is reduced in the cerebral cortex, thalamus, hippocampus, amygdala, and hypothalamus compared to in wild-type mice

respiratory system

increased bronchoconstrictive response ( J:141201 )

• mice treated with U46619 or acetylcholine exhibit increased bronchoconstriction compared with similarly treated wild-type mice

• pretreatment with naproxen, diclofenac, or ibuprofen does not increase bronchoconstriction induced by U46619 or acetylcholine unlike in similarly treated wild-type mice

skeleton

decreased susceptibility to induced arthritis ( J:110716 )

• FCA-treated female mice exhibit reduced joint destruction and swelling compared with similarly treated male or wild-type mice

Allelic Composition	Ptgs1^tm1Unc/Ptgs1^tm1Unc
Genetic Background	B6;129P2-Ptgs1^tm1Unc/Tac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptgs1^tm1Unc mutation (0 available); any Ptgs1 mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

decreased digestive secretion ( J:103642 )

• baseline net alkali secretion is reduced compared to in wild-type mice and is not affected by treatment with SC560 or rofecoxib unlike similarly treated wild-type mice

abnormal stomach pH ( J:103642 )

• the thickness of the pH gradient in the stomach is reduced compared to in wild-type mice

• indomethacin-treated mice fail to exhibit a disruption in pH gradient in the stomach unlike similarly treated wild-type mice

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:112346 )

N	• mice exhibit normal bone healing

decreased physiological sensitivity to xenobiotic ( J:103642 )

• indomethacin-treated mice fail to exhibit a disruption in pH gradient in the stomach unlike similarly treated wild-type mice

muscle

muscle phenotype ( J:107751 )

N	• mice exhibit normal muscle regeneration following injury

behavior/neurological

behavior/neurological phenotype ( J:141610 )

N	• mice exhibit normal seizure response to kainate

nervous system

nervous system phenotype ( J:141610 )

N	• mice exhibit normal seizure response to kainate

Allelic Composition	Ptgs1^tm1Unc/Ptgs1^tm1Unc
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptgs1^tm1Unc mutation (0 available); any Ptgs1 mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

increased small intestinal crypt cell apoptosis ( J:108679 )

• mice treated with gamma radiation exhibit increased apoptosis in intestinal crypt epithelial cells compared with similarly treated wild-type mice

• 6-hours after 8-Gy gamma irradiation intestinal crypt epithelial cell apoptosis is 1.9-fold higher than in similarly treated wild-type mice

abnormal small intestine crypts of Lieberkuhn morphology ( J:108679 )

• crypt survival is decreased in radiation-treated mice due to a decrease in crypt stem cell survival unlike in similarly treated wild-type mice

homeostasis/metabolism

decreased prostaglandin level ( J:108679 )

• radiation-treated mice exhibit reduced prostaglandin levels compared with similarly treated wild-type mice

cellular

increased cellular sensitivity to gamma-irradiation ( J:108679 )

• mice treated with gamma radiation exhibit increased apoptosis in intestinal crypt epithelial cells compared with similarly treated wild-type mice

• 6-hours after 8-Gy gamma irradiation intestinal crypt epithelial cell apoptosis is 1.9-fold higher than in similarly treated wild-type mice

increased small intestinal crypt cell apoptosis ( J:108679 )

• mice treated with gamma radiation exhibit increased apoptosis in intestinal crypt epithelial cells compared with similarly treated wild-type mice

• 6-hours after 8-Gy gamma irradiation intestinal crypt epithelial cell apoptosis is 1.9-fold higher than in similarly treated wild-type mice

endocrine/exocrine glands

abnormal small intestine crypts of Lieberkuhn morphology ( J:108679 )

• crypt survival is decreased in radiation-treated mice due to a decrease in crypt stem cell survival unlike in similarly treated wild-type mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:60668 )

• in a model of acute DSS-induced colitis, homozygotes display increased mortality in response to 10% DSS, with only a 50% survival rate on day 5; in contrast, all wild-type mice survive the 5-day treatment

perinatal lethality, incomplete penetrance ( J:64073 )

• birthing is delayed resulting in decreased survival of pups

• however, treatment with PGF2alpha or PGE2 increase pup survival

growth/size/body

enlarged spleen ( J:60668 )

• in DSS-treated mice compared with similarly treated wild-type mice

reproductive system

abnormal corpus luteum morphology ( J:50148 )

• at day 19 of gestation, mutant corpora lutea retain obvious vascular spaces, a uniform cellular morphology, and an organized luteal architecture, indicating delayed luteolysis

abnormal parturition ( J:50148 )

• the delivery of homozygous mutant litters is significantly retarded (21.6 0.2 days) relative to the delivery of wild-type litters (19.6 0.2 days); once initiated, labor progresses rapidly

• many of the pups arising from matings of homozygous deficient parents die perinatally despite normal pup size, degree of development, and litter size

• likewise, matings of homozygous mutant females with wild-type or heterozygous males result in delayed delivery at day 22 0.5 of gestation with reduced fetal viability

• administration of prostaglandin F receptor to homozygous mutant matings at day 19.5 of gestation results in labor within 24 hrs and restores neonatal viability

• matings of homozygous mutant males with heterozygous females do not result in increased neonatal mortality, suggesting that female heterozygotes exhibit a normal onset of labor

delayed parturition ( J:64073 )

• birthing is delayed resulting in decreased survival of pups

• Background Sensitivity: delayed in birthing are greater than on a CD-1 mixed background

• however, parturition length is normal and treatment with PGF2alpha or PGE2 decreased delayed birthing

abnormal uterine environment ( J:29511 )

• both male and female homozygotes are fertile and survive well; however, pup survival is severely reduced when homozygous mutant mice are mated to each other, despite normal litter sizes

homeostasis/metabolism

abnormal response of heart to induced stress ( J:103388 )

• following ischemia, recovery of contractile function is lower than in similarly treated wild-type mice

• however, pre-conditioned mice exhibit normal recovery from myocardial ischemia

increased circulating progesterone level ( J:50148 )

• at day 19 of gestation, gravid female homozygotes exhibit significantly higher plasma progesterone concentrations relative to wild-type mice

• in addition, induction of uterine oxytocin receptors is delayed

abnormal blood coagulation ( J:29511 )

decreased platelet aggregation ( J:29511 )

• in vitro, platelets from homozygous mutant mice aggregate more slowly and to a lesser extent than wild-type platelets in response to arachidonic acid

decreased prostaglandin level ( J:29511 , J:50148 , J:60668 , J:103388 , J:117986 )

• homozygous mutant peritoneal macrophages display a >99% reduction in basal PGE2 production relative to wild-type macrophages (J:29511)

• at day 19 of gestation, female homozygotes have uterine PGF2alpha concentrations only 1-3% of those found in wild-type or Oxt^tm1Ljm mutant females; ovarian concentrations are also severely reduced (J:50148)

• homozygotes exhibit loss of constitutive mucosal PGE2 production in unstimulated tissues, including the colon, stomach, duodenum, jejunum, ileum, and cecum; their colonic PGE2 concentrations are equal to those of wild-type controls after DSS-induced injury (J:60668)

• pre- and post-ischemia compared with similarly treated wild-type mice (J:103388)

• in keratinocyte cultures (J:117986)

abnormal urine homeostasis ( J:110043 )

• during sleep, mice exhibit higher normetanephrine (52%) and reduced prostaglandin (76%) and nitrate plus nitrite (35%) excretion compared with wild-type mice

• mice exhibit less of a reduction in normetanephrine excretion during sleep compared with wild-type mice

• however, awake time excretion of prostaglandin, nitrate plus nitrite, aldosterone, sodium, and potassium is normal

decreased urine prostaglandin level ( J:110043 )

• during sleep, mice exhibit reduced prostaglandin (76%) excretion compared with wild-type mice

• however, awake time excretion of prostaglandin is normal

increased susceptibility to xenobiotic induced morbidity/mortality ( J:60668 )

decreased physiological sensitivity to xenobiotic ( J:146321 )

• mice do not exhibit a decrease in internal anal sphincter muscle tone when treated with SC-560 unlike similarly treated wild-type mice

• however, mice exhibit normal sensitivity to the Ptsg2 inhibitor rofecoxib

increased susceptibility to injury ( J:60668 )

• in a model of acute dextran sodium sulfate (DSS)-induced colitis, homozygotes display increased susceptibility to a low-dose (2.5%) of DSS that causes mild colonic epithelial injury in wild-type mice

• notably, homozygotes treated with low-dose DSS display intermediate damage of the colonic mucosa relative to wild-type and Ptgs2^tm1Unc homozygous mutant mice

immune system

increased susceptibility to induced colitis ( J:60668 , J:158426 )

• in response to low-dose (2.5%) DSS-induced colitis, homozygotes display a significantly higher clinical score than wild-type mice (days 4 and 5), based on diarrhea, fecal blood, and weight loss (J:60668)

• DSS-treated homozygotes display intermediate values of colonic shortening, crypt damage, splenomegaly, leukocytosis and anemia relative to DSS-treated wild-type and Ptgs2^tm1Unc mutant mice (J:60668)

• pharmacological treatment with a selective PTGS2 inhibitor worsens low-dose DSS-induced colitis and enhances mortality (J:60668)

• mice treated with azoxymethane and dextran sulfate sodium exhibit greater weight loss compared with similarly treated wild-type mice (J:158426)

enlarged spleen ( J:60668 )

• in DSS-treated mice compared with similarly treated wild-type mice

increased susceptibility to endotoxin shock ( J:75611 )

• LPS-treated mice exhibit more weight loss than similarly treated wild-type mice

decreased inflammatory response ( J:29511 )

• F2 homozygotes show a significantly reduced inflammatory response (~30% of wild-type) to topical application of arachidonic acid, as determined by ear thickness

• in contrast, homozygotes exhibit a normal inflammatory response to tumor promoter TPA

cardiovascular system

abnormal blood flow velocity ( J:110043 )

• under anesthesia, renal blood flow is reduced compared to in similarly treated wild-type mice

increased renal vascular resistance ( J:110043 )

• under anesthesia

abnormal circadian regulation of systemic arterial blood pressure ( J:110043 )

• the ratio of sleep to wake blood pressure is 8.6% higher than in wild-type mice

abnormal circadian regulation of heart rate ( J:110043 )

• the ratio of sleep to wake heart rate is 5.7% higher than in wild-type mice

abnormal response of heart to induced stress ( J:103388 )

• following ischemia, recovery of contractile function is lower than in similarly treated wild-type mice

• however, pre-conditioned mice exhibit normal recovery from myocardial ischemia

increased mean systemic arterial blood pressure ( J:110043 )

• during sleep or under anesthesia

renal/urinary system

increased renal vascular resistance ( J:110043 )

• under anesthesia

abnormal urine homeostasis ( J:110043 )

• during sleep, mice exhibit higher normetanephrine (52%) and reduced prostaglandin (76%) and nitrate plus nitrite (35%) excretion compared with wild-type mice

• mice exhibit less of a reduction in normetanephrine excretion during sleep compared with wild-type mice

• however, awake time excretion of prostaglandin, nitrate plus nitrite, aldosterone, sodium, and potassium is normal

decreased urine prostaglandin level ( J:110043 )

• during sleep, mice exhibit reduced prostaglandin (76%) excretion compared with wild-type mice

• however, awake time excretion of prostaglandin is normal

abnormal kidney morphology ( J:29511 )

• at 2-5 months, 3 of 6 kidneys examined display one or two small foci per section of basophilic, immature tubules; the size and frequency of these lesions does not change with age

• all other tissues (including liver, spleen, GI and reproductive tract, lung and heart) appear microscopically normal

increased renal glomerular filtration rate ( J:110043 )

• under anesthesia

endocrine/exocrine glands

abnormal corpus luteum morphology ( J:50148 )

• at day 19 of gestation, mutant corpora lutea retain obvious vascular spaces, a uniform cellular morphology, and an organized luteal architecture, indicating delayed luteolysis

digestive/alimentary system

digestive/alimentary phenotype ( J:29511 , J:60668 )

• F2 and F3 homozygotes are generally healthy and do not develop spontaneous gastric ulcers but display reduced gastric ulceration after gavage with indomethacin relative to wild-type mice (J:29511)

• homozygotes do not exhibit any clinical or histologic signs of spontaneous gastrointestinal inflammation, despite significantly reduced mucosal PGE2 levels (J:60668)

increased susceptibility to induced colitis ( J:60668 , J:158426 )

• pharmacological treatment with a selective PTGS2 inhibitor worsens low-dose DSS-induced colitis and enhances mortality (J:60668)

• mice treated with azoxymethane and dextran sulfate sodium exhibit greater weight loss compared with similarly treated wild-type mice (J:158426)

hematopoietic system

enlarged spleen ( J:60668 )

• in DSS-treated mice compared with similarly treated wild-type mice

decreased platelet aggregation ( J:29511 )

• in vitro, platelets from homozygous mutant mice aggregate more slowly and to a lesser extent than wild-type platelets in response to arachidonic acid

muscle

hypotonia ( J:146321 )

• in the internal anal sphincter

neoplasm

neoplasm ( J:158426 )

N	• mice treated with azoxymethane and dextran sulfate sodium exhibit wild-type colon tumor incidence and histology

integument

abnormal keratinocyte differentiation ( J:117986 )

• keratinocyte cultures exhibit a 5-fold increase in expression of K1, a marker of differentiation, compared with wild-type cells

cellular

abnormal keratinocyte differentiation ( J:117986 )

• keratinocyte cultures exhibit a 5-fold increase in expression of K1, a marker of differentiation, compared with wild-type cells

Allelic Composition	Ptgs1^tm1Unc/Ptgs1^tm1Unc
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptgs1^tm1Unc mutation (0 available); any Ptgs1 mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

delayed parturition ( J:64073 )

• birthing is delayed resulting in decreased survival of pups

• Background Sensitivity: delays in birthing are not as great as in a C57BL/6 129P2/OlaHsd background

• however, parturition length is normal and treatment with PGF2alpha or PGE2 decreased delayed birthing

Allelic Composition	Ptgs1^tm1Unc/Ptgs1^tm1Unc
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * DBA/1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptgs1^tm1Unc mutation (0 available); any Ptgs1 mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal wound healing ( J:126734 )

• the tensile strength of skin at the site of wound healing is 75% less than in similarly treated wild-type mice

• 12 days after wounding, macrophage numbers at the wound decline faster than in wild-type mice or Ptgs2^tm1Unc homozygotes

Allelic Composition	Ptgs1^tm1Unc/Ptgs1^tm1Unc
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptgs1^tm1Unc mutation (0 available); any Ptgs1 mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased prostaglandin level ( J:106147 )

• prostaglandin E2 protein is nearly undetectable in lactating mamamary glands or breast milk from null female mice on day 4 of lactation

Allelic Composition	Ptgs1^tm1Unc/Ptgs1^tm1Unc
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptgs1^tm1Unc mutation (0 available); any Ptgs1 mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

maternal effect ( J:144423 )

• newborn survival of pups from homozygous females is reduced compared to in wild-type mice

reproductive system

delayed parturition ( J:144423 )

• delayed

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:54450 )

N	• mice exhibit a normal thermal response to LPS

cardiovascular system

cardiovascular system phenotype ( J:109021 )

N	• mice exhibit normal retinal responses to hypoxia

Allelic Composition	Ptgs1^tm1Unc/Ptgs1^tm1Unc
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptgs1^tm1Unc mutation (0 available); any Ptgs1 mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:124756 )

N	• bone marrow cultures exhibit normal prostaglandin production in response to stimulation with 1,25-dihydroxyvitamin D3 (1,25-D) or parathyroid hormone (PTH)

skeleton

skeleton phenotype ( J:124756 )

N	• bone marrow cultures exhibit normal TRAP+ mononuclear cells (osteoclast) production in response to stimulation with 1,25-dihydroxyvitamin D3 (1,25-D) or parathyroid hormone (PTH)

Allelic Composition	Ptgs1^tm1Unc/Ptgs1⁺
Genetic Background	D1.129P2-Ptgs1^tm1Unc

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptgs1^tm1Unc mutation (0 available); any Ptgs1 mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

growth/size/body region phenotype ( J:102779 )

N	• mice fed a high fat and sucrose diet exhibit normal weight gain

homeostasis/metabolism

increased prostaglandin level ( J:102779 )

• fat pad tissue from mice fed a high fat and sucrose diet exhibit a 2-fold increase in prostaglandin production compared with tissues from similarly treated wild-type mice

Allelic Composition	Ptgs1^tm1Unc/Ptgs1⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptgs1^tm1Unc mutation (0 available); any Ptgs1 mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased prostaglandin level ( J:29511 )

• heterozygous mutant peritoneal macrophages display a 70% reduction in basal PGE2 production relative to wild-type macrophages

Allelic Composition	Ptgs1^tm1Unc/Ptgs1⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptgs1^tm1Unc mutation (0 available); any Ptgs1 mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased prostaglandin level ( J:106147 )

• levels of prostaglandin E2 are significantly lower in mammary glands of heterozygotes on day 4 of lactation compared to wild-type

Allelic Composition	Nos3^tm1Plh/Nos3^tm1Plh Ptgs1^tm1Unc/Ptgs1^tm1Unc
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nos3^tm1Plh mutation (1 available); any Nos3 mutation (56 available)
Ptgs1^tm1Unc mutation (0 available); any Ptgs1 mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

increased systemic arterial systolic blood pressure ( J:108540 )

• in male, but not female, mice

abnormal blood vessel physiology ( J:108540 )

• relaxation of mesenteric arteries and the aorta of acetylcholine-treat male mice is inhibited unlike similarly treated female and wild-type mice

• male mice fail to exhibit a bradykinin-dependent decrease in blood pressure unlike similarly treated female mice

homeostasis/metabolism

decreased prostaglandin level ( J:108540 )

decreased physiological sensitivity to xenobiotic ( J:108540 )

• relaxation of mesenteric arteries and the aorta of acetylcholine-treat male mice is inhibited unlike similarly treated female and wild-type mice

• male mice fail to exhibit a bradykinin-dependent decrease in blood pressure unlike similarly treated female mice

Allelic Composition	Ptgs1^tm1Unc/Ptgs1^tm1Unc Ptgs2^tm1.1Fun/Ptgs2^tm1.1Fun
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptgs1^tm1Unc mutation (0 available); any Ptgs1 mutation (44 available)
Ptgs2^tm1.1Fun mutation (1 available); any Ptgs2 mutation (72 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:109548 )

• all die within the first day of life

cardiovascular system

patent ductus arteriosus ( J:109548 )

cellular

patent ductus arteriosus ( J:109548 )

Allelic Composition	Ptgs1^tm1Unc/Ptgs1^tm1Unc Oxt^tm1Ljm/Oxt^tm1Ljm
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Oxt^tm1Ljm mutation (0 available); any Oxt mutation (20 available)
Ptgs1^tm1Unc mutation (0 available); any Ptgs1 mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:50148 )

N	• at day 19 of gestation, both wild-type and double homozygous mutant corpora lutea exhibit an amorphous cellular morphology and disrupted luteal architecture, suggesting normal luteolysis

delayed parturition ( J:50148 )

• surprisingly, matings of double homozygous deficient males and females exhibit a normal onset of labor at 19.8 +/- 0.5 days of gestation; however, such matings often result in extended labor with some litters delivering over a 2-day period

endocrine/exocrine glands

lactation failure ( J:50148 )

• double homozygous mothers fail to lactate normally; as a result, pups do not survive

homeostasis/metabolism

decreased prostaglandin level ( J:50148 )

• at day 19 of gestation, double homozygotes have uterine PGF2alpha concentrations only 1-3% of those found in wild-type or Oxt^tm1Ljm single homozygotes; ovarian concentrations are also severely reduced

integument

lactation failure ( J:50148 )

• double homozygous mothers fail to lactate normally; as a result, pups do not survive

Allelic Composition	Ptgs1^tm1Unc/Ptgs1^tm1Unc Ptgs2^tm1Unc/Ptgs2^tm1Unc
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptgs1^tm1Unc mutation (0 available); any Ptgs1 mutation (44 available)
Ptgs2^tm1Unc mutation (0 available); any Ptgs2 mutation (72 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:64073 )

• mice die within 24 hours of birth with wide patent ductus arterious

cardiovascular system

patent ductus arteriosus ( J:64073 )

cellular

patent ductus arteriosus ( J:64073 )

Allelic Composition	Ptgs1^tm1Unc/Ptgs1⁺ Ptgs2^tm1Unc/Ptgs2⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

delayed parturition ( J:67208 )

• parturition is delayed

Allelic Composition	Ptgs1^tm1Unc/Ptgs1^tm1Unc Ptgs2^tm1Unc/Ptgs2⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

delayed parturition ( J:67208 )

• parturition is delayed

Allelic Composition	Apc^Min/Apc⁺ Ptgs1^tm1Unc/Ptgs1^tm1Unc
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^Min mutation (12 available); any Apc mutation (154 available)
Ptgs1^tm1Unc mutation (0 available); any Ptgs1 mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:64401 )

N	• mice live 12 months or longer unlike Apc^Min heterozygotes that die after 7 to 8 months

neoplasm

decreased tumor incidence ( J:64401 )

• mice form 77% fewer, smaller intestinal tumors than in Apc^Min heterozygotes

homeostasis/metabolism

decreased prostaglandin level ( J:64401 )

• prostaglandin levels in normal intestinal tissue is lower than in Apc^Min heterozygotes

• intestinal tumor tissue fails to exhibit an increase in prostaglandin levels unlike in Apc^Min heterozygotes

digestive/alimentary system

intestine polyps ( J:64401 )

Allelic Composition	Ptgs1^tm1Unc/Ptgs1⁺ Ptgs2^tm1Unc/Ptgs2^tm1Unc
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:67208 )

• 79% of mice die within the first 48 hours of birth

cardiovascular system

patent ductus arteriosus ( J:67208 )

• 74% of mice that die within the first 48 hrs of birth exhibit patent ductus arteriosus

cellular

patent ductus arteriosus ( J:67208 )

• 74% of mice that die within the first 48 hrs of birth exhibit patent ductus arteriosus

Allelic Composition	Ptgs1^tm1Unc/Ptgs1^tm1Unc Ptgs2^tm1Unc/Ptgs2^tm1Unc
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:67208 )

• more than 50% of mice become cyanotic and die within the first 30 minutes of Caesarian delivery

postnatal lethality, complete penetrance ( J:67208 )

• 100% of mice die within the first 48 hours of birth

cardiovascular system

patent ductus arteriosus ( J:67208 )

• all mice exhibit patent ductus arteriosus

• unlike in wild type mice, treatment with indomethacin does not induce premature closure of the ductus arteriosus and associated neonatal lethality

respiratory system

respiratory distress ( J:67208 )

• in mice that die within the first 30 minutes of delivery

homeostasis/metabolism

cyanosis ( J:67208 )

• more than 50% of mice become cyanotic and die within the first 30 minutes of Caesarian delivery

cellular

patent ductus arteriosus ( J:67208 )

• all mice exhibit patent ductus arteriosus

• unlike in wild type mice, treatment with indomethacin does not induce premature closure of the ductus arteriosus and associated neonatal lethality

Allelic Composition	Apc^Min/Apc⁺ Ptgs1^tm1Unc/Ptgs1⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:64401 )

• mice survive 10 months unlike Apc^Min heterozygotes that die after 7 to 8 months

neoplasm

decreased tumor incidence ( J:64401 )

• mice form 43% fewer tumors than in Apc^Min heterozygotes

digestive/alimentary system

intestine polyps ( J:64401 )

Allelic Composition	Hr^hr/Hr^hr Ptgs1^tm1Unc/Ptgs1⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * SKH1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hr^hr mutation (17 available); any Hr mutation (84 available)
Ptgs1^tm1Unc mutation (0 available); any Ptgs1 mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

neoplasm ( J:121635 )

N	• UV-exposed mice exhibit normal induction of tumors

homeostasis/metabolism

decreased prostaglandin level ( J:121635 )

• 50% in the epidermis

cellular

increased cell proliferation ( J:121635 )

• skin from UV-treated mice exhibits 20% less basal cell proliferation than in skin from similarly treated wild-type mice

Allelic Composition	Cnr1^tm1Zim/Cnr1^tm1Zim Ptgs1^tm1Unc/Ptgs1^tm1Unc
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cnr1^tm1Zim mutation (2 available); any Cnr1 mutation (43 available)
Ptgs1^tm1Unc mutation (0 available); any Ptgs1 mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

early parturition ( J:144423 )

• premature parturition

mortality/aging

mortality/aging ( J:144423 )

N	• newborns of homozygous females exhibit normal survival

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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