All Phenotypes Il2rb<tm1Mak> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Il2rb^tm1Mak/Il2rb^tm1Mak	B6.129-Il2rb^tm1Mak	MGI:3760261
hm2	Il2rb^tm1Mak/Il2rb^tm1Mak	C.129-Il2rb^tm1Mak	MGI:3760262
hm3	Il2rb^tm1Mak/Il2rb^tm1Mak	D2.129-Il2rb^tm1Mak	MGI:3760263
hm4	Il2rb^tm1Mak/Il2rb^tm1Mak	either: (involves: 129P2/OlaHsd) or (involves: 129S2/SvPas)	MGI:2179525
cx5	Il2rb^tm1Mak/Il2rb^tm1Mak Lck^tm1Mak/Lck^tm1Mak	involves: 129	MGI:3798942
cx6	Il2rb^tm1Mak/Il2rb^tm1Mak Rag2^tm1Fwa/Rag2^tm1Fwa	involves: 129 * 129S/SvEv	MGI:3829711

Allelic Composition	Il2rb^tm1Mak/Il2rb^tm1Mak
Genetic Background	B6.129-Il2rb^tm1Mak

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il2rb^tm1Mak mutation (5 available); any Il2rb mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

enlarged spleen ( J:113547 )

• in mice by 26 days of age

• can be prevented with adoptive transfer at birth of 1 x 10⁵ CD25-positive CD4 T cells from wild-type mice

increased susceptibility to autoimmune hemolytic anemia ( J:113547 )

• by 26 days of age

• can be prevented with adoptive transfer at birth of 1 x 10⁵ CD25-positive CD4 T cells from wild-type mice

abnormal lymphocyte morphology ( J:113547 )

decreased regulatory T cell number ( J:113547 )

• there is a 2 to 5 fold reduction in the percentage of CD25-postive CD4 T cells in both the thymus and lymph nodes

• transgeneic expression of Il2rb in the thymus rescues number of regulatory T cells

abnormal spleen periarteriolar lymphoid sheath morphology ( J:113547 )

• increased in size at 26 days of age

• can be prevented with adoptive transfer at birth of 1 x 10⁵ CD25-positive CD4 T cells from wild-type mice

abnormal T cell activation ( J:113547 )

• percentage of CD4 and CD8 T cells that express high levels of activation markers is increased

• T cells are hyporesponsive to inflammatory cytokines as measured by in vitro proliferation assays

• expression of activation markers is normalized upon transfer of 1 x 10⁵ CD25-positive CD4 T cells from wild-type mice

decreased T cell proliferation ( J:113547 )

• in mice by 26 days of age

• can be prevented with adoptive transfer at birth of 1 x 10⁵ CD25-positive CD4 T cells from wild-type mice

enlarged lymph nodes ( J:113547 )

• in mice by 26 days of age

• can be prevented with adoptive transfer at birth of 1 x 10⁵ CD25-positive CD4 T cells from wild-type mice

increased anti-double stranded DNA antibody level ( J:113547 )

• in mice by 26 days of age

• can be prevented with adoptive transfer at birth of 1 x 10⁵ CD25-positive CD4 T cells from wild-type mice

abnormal response to transplant ( J:113547 )

• adoptively transfered regulatory T cell expand at least 15 to 20 times until they make up 3-5% of the total cells in the lymph nodes and spleen

• regulatory T cells were unable to engraft in wild-type mice

hematopoietic system

enlarged spleen ( J:113547 )

• in mice by 26 days of age

• can be prevented with adoptive transfer at birth of 1 x 10⁵ CD25-positive CD4 T cells from wild-type mice

increased susceptibility to autoimmune hemolytic anemia ( J:113547 )

• by 26 days of age

• can be prevented with adoptive transfer at birth of 1 x 10⁵ CD25-positive CD4 T cells from wild-type mice

abnormal lymphocyte morphology ( J:113547 )

decreased regulatory T cell number ( J:113547 )

• there is a 2 to 5 fold reduction in the percentage of CD25-postive CD4 T cells in both the thymus and lymph nodes

• transgeneic expression of Il2rb in the thymus rescues number of regulatory T cells

abnormal spleen periarteriolar lymphoid sheath morphology ( J:113547 )

• increased in size at 26 days of age

• can be prevented with adoptive transfer at birth of 1 x 10⁵ CD25-positive CD4 T cells from wild-type mice

abnormal T cell activation ( J:113547 )

• percentage of CD4 and CD8 T cells that express high levels of activation markers is increased

• T cells are hyporesponsive to inflammatory cytokines as measured by in vitro proliferation assays

• expression of activation markers is normalized upon transfer of 1 x 10⁵ CD25-positive CD4 T cells from wild-type mice

decreased T cell proliferation ( J:113547 )

• in mice by 26 days of age

• can be prevented with adoptive transfer at birth of 1 x 10⁵ CD25-positive CD4 T cells from wild-type mice

growth/size/body

enlarged spleen ( J:113547 )

• in mice by 26 days of age

• can be prevented with adoptive transfer at birth of 1 x 10⁵ CD25-positive CD4 T cells from wild-type mice

cellular

decreased T cell proliferation ( J:113547 )

• in mice by 26 days of age

• can be prevented with adoptive transfer at birth of 1 x 10⁵ CD25-positive CD4 T cells from wild-type mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:113547 )

• Background Sensitivity: mice die between 3 to 5 weeks of age

• can be prevented with adoptive transfer at birth of 3 x 10⁴ CD25-positive CD4 T cells from wild-type mice

immune system

increased susceptibility to autoimmune hemolytic anemia ( J:113547 )

• cause of death at 3 to 5 weeks of age

• can be prevented with adoptive transfer at birth of 3 x 10⁴ CD25-positive CD4 T cells from wild-type mice

abnormal lymphocyte morphology ( J:113547 )

abnormal T cell clonal deletion ( J:113547 )

• expected deletion occurs of T cells that recognize BALB/c specific superantigens, indicating the autoimmunity associated with this mouse strain is unlikely to be a failure to eliminate self-reactive T cells

decreased CD8-positive, alpha-beta T cell number ( J:113547 )

• number is reduced by a third upon transfer of 3 x 10⁴ CD25-positive CD4 T cells from wild-type mice

abnormal T cell activation ( J:113547 )

• percentage of CD4 and CD8 T cells that express high levels of activation markers is increased

• T cells are hyporesponsive to inflammatory cytokines as measured by in vitro proliferation assays

• expression of activation markers is normalized upon transfer of 3 x 10⁴ CD25-positive CD4 T cells from wild-type mice

decreased T cell proliferation ( J:113547 )

• by 3 to 5 weeks of age

• can be prevented with adoptive transfer at birth of 3 x 10⁴ CD25-positive CD4 T cells from wild-type mice

abnormal immune system organ morphology ( J:113547 )

enlarged spleen ( J:113547 )

• by 3 to 5 weeks of age

• can be prevented with adoptive transfer at birth of 3 x 10⁴ CD25-positive CD4 T cells from wild-type mice

abnormal marginal zone B cell morphology ( J:113547 )

• extension of marginal zones found in the spleen

• can be prevented with adoptive transfer at birth of 3 x 10⁴ CD25-positive CD4 T cells from wild-type mice

abnormal spleen periarteriolar lymphoid sheath morphology ( J:113547 )

• increase in size

• can be prevented with adoptive transfer at birth of 3 x 10⁴ CD25-positive CD4 T cells from wild-type mice

enlarged lymph nodes ( J:113547 )

• by 3 to 5 weeks of age

• can be prevented with adoptive transfer at birth of 3 x 10⁴ CD25-positive CD4 T cells from wild-type mice

increased anti-double stranded DNA antibody level ( J:113547 )

• by 3 to 5 weeks of age

• can be prevented with adoptive transfer at birth of 3 x 10⁴ CD25-positive CD4 T cells from wild-type mice

liver inflammation ( J:113547 )

• large atypical lymphocytes are observed in the liver

• no inflammation is observed in mice that receive transfer of 3 x 10⁴ wild-type CD25-positive CD4 T

liver/biliary system

liver inflammation ( J:113547 )

• large atypical lymphocytes are observed in the liver

• no inflammation is observed in mice that receive transfer of 3 x 10⁴ wild-type CD25-positive CD4 T

hematopoietic system

enlarged spleen ( J:113547 )

• by 3 to 5 weeks of age

• can be prevented with adoptive transfer at birth of 3 x 10⁴ CD25-positive CD4 T cells from wild-type mice

increased susceptibility to autoimmune hemolytic anemia ( J:113547 )

• cause of death at 3 to 5 weeks of age

• can be prevented with adoptive transfer at birth of 3 x 10⁴ CD25-positive CD4 T cells from wild-type mice

abnormal lymphocyte morphology ( J:113547 )

abnormal T cell clonal deletion ( J:113547 )

decreased CD8-positive, alpha-beta T cell number ( J:113547 )

• number is reduced by a third upon transfer of 3 x 10⁴ CD25-positive CD4 T cells from wild-type mice

abnormal marginal zone B cell morphology ( J:113547 )

• extension of marginal zones found in the spleen

• can be prevented with adoptive transfer at birth of 3 x 10⁴ CD25-positive CD4 T cells from wild-type mice

abnormal spleen periarteriolar lymphoid sheath morphology ( J:113547 )

• increase in size

• can be prevented with adoptive transfer at birth of 3 x 10⁴ CD25-positive CD4 T cells from wild-type mice

abnormal T cell activation ( J:113547 )

• percentage of CD4 and CD8 T cells that express high levels of activation markers is increased

• T cells are hyporesponsive to inflammatory cytokines as measured by in vitro proliferation assays

• expression of activation markers is normalized upon transfer of 3 x 10⁴ CD25-positive CD4 T cells from wild-type mice

decreased T cell proliferation ( J:113547 )

• by 3 to 5 weeks of age

• can be prevented with adoptive transfer at birth of 3 x 10⁴ CD25-positive CD4 T cells from wild-type mice

growth/size/body

enlarged spleen ( J:113547 )

• by 3 to 5 weeks of age

• can be prevented with adoptive transfer at birth of 3 x 10⁴ CD25-positive CD4 T cells from wild-type mice

cellular

decreased T cell proliferation ( J:113547 )

• by 3 to 5 weeks of age

• can be prevented with adoptive transfer at birth of 3 x 10⁴ CD25-positive CD4 T cells from wild-type mice

Allelic Composition	Il2rb^tm1Mak/Il2rb^tm1Mak
Genetic Background	D2.129-Il2rb^tm1Mak

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il2rb^tm1Mak mutation (5 available); any Il2rb mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal T cell clonal deletion ( J:113547 )

• expected deletion occurs of T cells that recognize DBA/2 specific superantigens, indicating the autoimmunity associated with this mouse strain is unlikely to be a failure to eliminate self-reactive T cells

hematopoietic system

abnormal T cell clonal deletion ( J:113547 )

Allelic Composition	Il2rb^tm1Mak/Il2rb^tm1Mak
Genetic Background	either: (involves: 129P2/OlaHsd) or (involves: 129S2/SvPas)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il2rb^tm1Mak mutation (5 available); any Il2rb mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:25940 )

• death occurs by 12 weeks of age

growth/size/body

weight loss ( J:25940 )

• mice start losing weight at three weeks of age

enlarged spleen ( J:25940 )

• is observed by three weeks of age

immune system

thymus hypoplasia ( J:25940 )

• about 10 fold less thymocytes compared to wild-type mice at six weeks of age

enlarged spleen ( J:25940 )

• is observed by three weeks of age

increased susceptibility to autoimmune hemolytic anemia ( J:25940 )

• mild anema occurs at 3 weeks of age

increased granulocyte number ( J:25940 )

• over 90% of cells in the spleen of 8 week old mice are composed of granulocytes and their precursors

increased neutrophil cell number ( J:25940 )

• are found in lymph nodes starting about 4 weeks of age

abnormal mononuclear cell morphology ( J:25940 )

decreased double-positive T cell number ( J:25940 )

• about 3.5 fold less DP T cells at six weeks of age

increased plasma cell number ( J:25940 )

• are found in lymph nodes starting about 4 weeks of age

decreased B cell number ( J:25940 )

• B cells are almost absent by 8 weeks of age

increased CD4-positive, alpha-beta T cell number ( J:25940 )

• increase of single-positive CD4 T cells in the thymus

increased CD8-positive, alpha-beta T cell number ( J:25940 )

• increase of single-positive CD8 T cells in the thymus

decreased memory T cell number ( J:25940 )

• memory T cells are not generated to LCMV virus

increased activated T cell number ( J:25940 )

• 4 fold increase in number of activated (CD69-positive) T cells from the mesenteric lymph nodes

abnormal B cell activation ( J:25940 )

• B cells are unable to respond to a T-cell independent antigen

increased IgE level ( J:25940 )

• 10 to 100 fold higher in the sera of 3 week old mice

increased IgG1 level ( J:25940 )

• 10 to 100 fold higher in the sera of 3 week old mice

abnormal T cell activation ( J:25940 )

• T cells fail to activate to a number of mitogens

enlarged lymph nodes ( J:25940 )

• is observed by three weeks of age

increased anti-nuclear antigen antibody level ( J:25940 )

• high concentrations occur in the sera by 3 weeks of age

endocrine/exocrine glands

thymus hypoplasia ( J:25940 )

• about 10 fold less thymocytes compared to wild-type mice at six weeks of age

abnormal sex gland morphology ( J:25940 )

• poorly developed genitalia are evident by six weeks of age

hematopoietic system

thymus hypoplasia ( J:25940 )

• about 10 fold less thymocytes compared to wild-type mice at six weeks of age

enlarged spleen ( J:25940 )

• is observed by three weeks of age

abnormal common myeloid progenitor cell morphology ( J:25940 )

• liver and spleen is infiltrated by large number of myeloid precursors

• around 8 weeks of age, bone marrow is also infiltrated

increased susceptibility to autoimmune hemolytic anemia ( J:25940 )

• mild anema occurs at 3 weeks of age

increased erythroid progenitor cell number ( J:25940 )

• increase numbers found in the blood between 3 and 8 weeks of age

increased granulocyte number ( J:25940 )

• over 90% of cells in the spleen of 8 week old mice are composed of granulocytes and their precursors

increased neutrophil cell number ( J:25940 )

• are found in lymph nodes starting about 4 weeks of age

abnormal mononuclear cell morphology ( J:25940 )

decreased double-positive T cell number ( J:25940 )

• about 3.5 fold less DP T cells at six weeks of age

increased plasma cell number ( J:25940 )

• are found in lymph nodes starting about 4 weeks of age

decreased B cell number ( J:25940 )

• B cells are almost absent by 8 weeks of age

increased CD4-positive, alpha-beta T cell number ( J:25940 )

• increase of single-positive CD4 T cells in the thymus

increased CD8-positive, alpha-beta T cell number ( J:25940 )

• increase of single-positive CD8 T cells in the thymus

decreased memory T cell number ( J:25940 )

• memory T cells are not generated to LCMV virus

increased activated T cell number ( J:25940 )

• 4 fold increase in number of activated (CD69-positive) T cells from the mesenteric lymph nodes

abnormal B cell activation ( J:25940 )

• B cells are unable to respond to a T-cell independent antigen

increased IgE level ( J:25940 )

• 10 to 100 fold higher in the sera of 3 week old mice

increased IgG1 level ( J:25940 )

• 10 to 100 fold higher in the sera of 3 week old mice

abnormal T cell activation ( J:25940 )

• T cells fail to activate to a number of mitogens

behavior/neurological

abnormal locomotor behavior ( J:25940 )

• mice are slow when moving

reproductive system

abnormal sex gland morphology ( J:25940 )

• poorly developed genitalia are evident by six weeks of age

integument

abnormal hair texture ( J:25940 )

• hair is fuzzy in appearance

Allelic Composition	Il2rb^tm1Mak/Il2rb^tm1Mak Lck^tm1Mak/Lck^tm1Mak
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il2rb^tm1Mak mutation (5 available); any Il2rb mutation (45 available)
Lck^tm1Mak mutation (1 available); any Lck mutation (93 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal maternal decidual layer morphology ( J:134589 )

• the decidual region is deficient in normal decidual cells and appears as a large area of adipose tissue

absent uterine NK cells ( J:134589 )

• uterine NK cells are virtually absent in the uteri of pregnant mice at day 14 of gestation

abnormal endometrium morphology ( J:134589 )

• the metrial gland and uterine NK cells are absent from the uteri of pregnant mice at day 14 of gestation

absent endometrial glands ( J:134589 )

• the metrial gland is absent from the uteri of pregnant mice at day 14 of gestation

immune system

absent uterine NK cells ( J:134589 )

• uterine NK cells are virtually absent in the uteri of pregnant mice at day 14 of gestation

embryo

abnormal maternal decidual layer morphology ( J:134589 )

• the decidual region is deficient in normal decidual cells and appears as a large area of adipose tissue

absent uterine NK cells ( J:134589 )

• uterine NK cells are virtually absent in the uteri of pregnant mice at day 14 of gestation

hematopoietic system

absent uterine NK cells ( J:134589 )

• uterine NK cells are virtually absent in the uteri of pregnant mice at day 14 of gestation

endocrine/exocrine glands

absent uterine NK cells ( J:134589 )

• uterine NK cells are virtually absent in the uteri of pregnant mice at day 14 of gestation

absent endometrial glands ( J:134589 )

• the metrial gland is absent from the uteri of pregnant mice at day 14 of gestation

Allelic Composition	Il2rb^tm1Mak/Il2rb^tm1Mak Rag2^tm1Fwa/Rag2^tm1Fwa
Genetic Background	involves: 129 * 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il2rb^tm1Mak mutation (5 available); any Il2rb mutation (45 available)
Rag2^tm1Fwa mutation (48 available); any Rag2 mutation (117 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased NK cell number ( J:142654 )

• Ncr(NKp46)⁺ NK1.1⁺ NK cells are essentially absent

• however, the NKp46⁺CD127⁺ NK1.1^- subset of intestinal natural killer cells is unaffected

hematopoietic system

decreased NK cell number ( J:142654 )

• Ncr(NKp46)⁺ NK1.1⁺ NK cells are essentially absent

• however, the NKp46⁺CD127⁺ NK1.1^- subset of intestinal natural killer cells is unaffected

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