All Phenotypes Npr2<cn> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Npr2^cn/Npr2^cn	AKR/J	MGI:2182597
hm2	Npr2^cn/Npr2^cn	involves: AKR/J	MGI:3828048
hm3	Npr2^cn/Npr2^cn	Not Specified	MGI:3842177
ht4	Npr2^cn/Npr2^slw	involves: AKR/J * C57BL/6 * DDY	MGI:3806088
cx5	Npr2^{tm2.1(cre/ERT2)Fgr}/Npr2^cn Tg(CAG-Bgeo/ALPP)1Lbe/0	involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * AKR/J * C57BL/6J	MGI:5568088

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:5109 )

• some die between weaning and 3 months of age from cyanosis

postnatal lethality, incomplete penetrance ( J:5109 )

• many die before weaning from malocclusion

cardiovascular system

abnormal blood circulation ( J:5109 )

craniofacial

abnormal craniofacial morphology ( J:5109 )

• bull dog-like appearance due to the domed head and shortened upper jaw

decreased cranium length ( J:5109 )

• skull length is reduced to 77% of normal

decreased cranium width ( J:5109 )

• skull width is reduced to 95% of normal

malocclusion ( J:5109 )

short maxilla ( J:5109 )

domed cranium ( J:5109 )

abnormal nose morphology ( J:5109 )

• short nose with a broad transverse depression across the base

growth/size/body

malocclusion ( J:5109 )

abnormal nose morphology ( J:5109 )

• short nose with a broad transverse depression across the base

abnormal postnatal growth/weight/body size ( J:5109 )

• square rumped

abnormal body weight ( J:5109 )

• organ weights at 17-34 days of age are about 37-60% of normal

• organ weights at 60 days of age are about 56-98% of normal

decreased body weight ( J:5109 )

• at birth, weigh slighly less than controls and adults never attain normal weight

postnatal growth retardation ( J:5109 )

• during the first few weeks, growth is greatly retarded

distended abdomen ( J:5109 )

limbs/digits/tail

brachydactyly ( J:5109 )

• short thick toes

short humerus ( J:5109 )

short radius ( J:5109 )

short ulna ( J:5109 )

short femur ( J:5109 )

short tibia ( J:5109 )

short limbs ( J:5109 )

short tail ( J:5109 )

• tail is reduced to 51% of normal

thick tail ( J:5109 )

skeleton

abnormal long bone epiphyseal plate morphology ( J:5109 )

abnormal long bone epiphyseal plate proliferative zone ( J:5109 )

• proliferating cartilage cell columns are shorter

decreased width of hypertrophic chondrocyte zone ( J:5109 )

decreased long bone epiphyseal plate size ( J:5109 )

• thinner epiphyseal plate

decreased length of long bones ( J:5109 )

• lengths of limb bones are 60 to 72% of normal

short humerus ( J:5109 )

short radius ( J:5109 )

short ulna ( J:5109 )

short femur ( J:5109 )

short tibia ( J:5109 )

short scapula ( J:5109 )

• reduced width of scapula

abnormal pelvic girdle bone morphology ( J:5109 )

• short pelvis

abnormal axial skeleton morphology ( J:5109 )

• axial skeleton is reduced to 68% of normal

decreased cranium length ( J:5109 )

• skull length is reduced to 77% of normal

decreased cranium width ( J:5109 )

• skull width is reduced to 95% of normal

malocclusion ( J:5109 )

short maxilla ( J:5109 )

domed cranium ( J:5109 )

short vertebral column ( J:5109 )

abnormal bone trabecula morphology ( J:5109 )

• primary trabeculae are shorter, less numerous, and not aligned as well as in controls

respiratory system

abnormal nose morphology ( J:5109 )

• short nose with a broad transverse depression across the base

homeostasis/metabolism

cyanosis ( J:5109 )

• some die from cyanosis

reproductive system

reduced fertility ( J:5109 )

• neither sex breeds well

hematopoietic system

small spleen ( J:5109 )

• spleen size is 37% of normal

immune system

small spleen ( J:5109 )

• spleen size is 37% of normal

Allelic Composition	Npr2^cn/Npr2^cn
Genetic Background	involves: AKR/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Npr2^cn mutation (2 available); any Npr2 mutation (61 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal sensory neuron innervation pattern ( J:153212 )

• a small percentage of sensory axons extend directly towards the central canal unlike in wild-type mice

abnormal spinal cord dorsal column morphology ( J:153212 )

• the dorsal funiculus is reduced in size compared to in wild-type mice

skeleton

abnormal skeleton development ( J:5934 )

• growth of femora and tibiae is sub-normal in pre-wean homozygotes and growth is severely interupted at weaning, between 21 and 28 days of age, before resuming slow growth

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
achondroplasia		DOID:4480	OMIM:100800	J:26341

Allelic Composition	Npr2^cn/Npr2^cn
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Npr2^cn mutation (2 available); any Npr2 mutation (61 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal basicranium morphology ( J:5849 )

• endochondral bones are markedly reduced in length but not in width

abnormal mandibular condyloid process morphology ( J:5849 )

• cartilage is reduced

abnormal long bone epiphyseal plate morphology ( J:8099 )

• disruption of the proximal tibial plate

• Background Sensitivity: modifiers may be responsible for 2 non-overlapping groups of 22 day old mice homozygous mice in a segregating stock; one group with marginal, one with serious disruption of the proximal tibial growth plate

abnormal chondrocyte morphology ( J:15335 )

• a larger than normal accumulation of glycogen is seen

• many hypertrophic chondrocytes fail to degenerate

craniofacial

abnormal basicranium morphology ( J:5849 )

• endochondral bones are markedly reduced in length but not in width

abnormal mandibular condyloid process morphology ( J:5849 )

• cartilage is reduced

Allelic Composition	Npr2^cn/Npr2^slw
Genetic Background	involves: AKR/J * C57BL/6 * DDY

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Npr2^cn mutation (2 available); any Npr2 mutation (61 available)
Npr2^slw mutation (1 available); any Npr2 mutation (61 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

disproportionate dwarf ( J:129973 )

• abnormal endochondral ossification leads to a short-limbed dwarfism in mice confirming the "slw" mutation is an allele of the Npr2 gene locus

Allelic Composition	Npr2^{tm2.1(cre/ERT2)Fgr}/Npr2^cn Tg(CAG-Bgeo/ALPP)1Lbe/0
Genetic Background	involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * AKR/J * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Npr2^cn mutation (2 available); any Npr2 mutation (61 available)
Npr2^{tm2.1(cre/ERT2)Fgr} mutation (0 available); any Npr2 mutation (61 available)
Tg(CAG-Bgeo/ALPP)1Lbe mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:205571 )

N	• at E15.5 formation of collaterals by cranial sensory axons is not affected by Npr2 deficiency • peripheral processes of the ophthalmic branch of the trigeminal nerve are not significantly affected by Npr2 deficiency

abnormal cranial nerve morphology ( J:205571 )

• at E12.5 axons from cranial sensory ganglia do not bifurcate at the entry zone to the brainstem

abnormal dorsal root ganglion morphology ( J:205571 )

• mice lack axon bifurcation of DRG neurons; axons only exhibit only turns with Npr2 deficiency

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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