All Phenotypes Oca2<p-J> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Oca2^p-J
pink-eyed dilution Jackson
MGI:1856127

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Oca2^p-J/Oca2^p-J	C3H/HeJ-Oca2^p-J/J	MGI:3581189
cx2	a/a Oca2^p-J/Oca2^p-J	involves: C3H/HeJ	MGI:4454423
cx3	a/a Lyst^bg/Lyst^bg Oca2^p-J/Oca2^p-J	involves: C3H/HeJ * C3H/Rl * C57BL/6J	MGI:4454430

Allelic Composition	Oca2^p-J/Oca2^p-J
Genetic Background	C3H/HeJ-Oca2^p-J/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Oca2^p-J mutation (4 available); any Oca2 mutation (69 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Diluted coat color and pink eyes of Oca2^p-J/Oca2^p-J mice (lower) compared to the Oca2^p-J/+ mouse (upper)

pigmentation

diluted coat color ( J:2108 )

• non-agouti mice are grey

• agouti mice are yellow with slate grey hair bases

decreased eye pigmentation ( J:2108 )

• the eyes are "pink"

vision/eye

decreased eye pigmentation ( J:2108 )

• the eyes are "pink"

integument

diluted coat color ( J:2108 )

• non-agouti mice are grey

• agouti mice are yellow with slate grey hair bases

Allelic Composition	a/a Oca2^p-J/Oca2^p-J
Genetic Background	involves: C3H/HeJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (463 available)
Oca2^p-J mutation (4 available); any Oca2 mutation (69 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal melanosome morphology ( J:5346 )

• reorganization of fibrillar melanosomes into particulate melanin granules, such that only 20% of melanosomes in adult retina are fibrillar in nature, the rest are particulate

abnormal choroid melanin granule morphology ( J:5346 )

• 2% of premelanosomes in the choroid are fused to form giant granules

abnormal melanogenesis ( J:5346 )

• premature termination of melanization of the premelanosome filaments in the retina

vision/eye

abnormal choroid melanin granule morphology ( J:5346 )

• 2% of premelanosomes in the choroid are fused to form giant granules

Allelic Composition	a/a Lyst^bg/Lyst^bg Oca2^p-J/Oca2^p-J
Genetic Background	involves: C3H/HeJ * C3H/Rl * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (463 available)
Lyst^bg mutation (6 available); any Lyst mutation (225 available)
Oca2^p-J mutation (4 available); any Oca2 mutation (69 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal melanosome morphology ( J:5346 )

• reorganization of fibrillar melanosomes into particulate melanin granules, such that only 35% of melanosomes in adult retina are fibrillar in nature, the rest are particulate

abnormal choroid melanin granule morphology ( J:5346 )

• 2% of premelanosomes in the choroid are fused to form giant granules

vision/eye

abnormal choroid melanin granule morphology ( J:5346 )

• 2% of premelanosomes in the choroid are fused to form giant granules

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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