Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
MitfMi-wh mutation
(8 available);
any
Mitf mutation
(72 available)
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pigmentation
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• pigment granules are absent at E11
• at E11.5 and E12, the pigment layer is irregullar, mainly in the dorsal region
• after E12 in some area the cells are columnar rather than cuboidal
• at all stages the number of mitoses is increased compared to control pigment layers
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• pigment granules are absent from the pigment layer at E11
• after E12, a few pigment granules may be found in the front edge of the pigment layer
• at birth a few pigment granules are present near the iris
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vision/eye
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• slightly reduced in size from E13 onwards
• irregularly formed surrounding less than half of the spherical lens
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• at E12 the choroid fissure is mostly closed but the joining of the retinal nervous layer is not smooth and a large retinal eversion is present at the rear of the optic cup where the fissure fails to close
• in newborns the retinal eversion remains obvious in the unclosed portions of the choroid fissure
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• slight increase in diameter at E11
• shorter and somewhat greater in diameter at E11.5 and E12
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• slightly smaller at birth
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• the lens fills the space normally occupied by the vitreous body
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• pigment granules are absent at E11
• at E11.5 and E12, the pigment layer is irregullar, mainly in the dorsal region
• after E12 in some area the cells are columnar rather than cuboidal
• at all stages the number of mitoses is increased compared to control pigment layers
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• pigment granules are absent from the pigment layer at E11
• after E12, a few pigment granules may be found in the front edge of the pigment layer
• at birth a few pigment granules are present near the iris
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• at birth, the layers are less clearly defined
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• at birth the choroid fissure is irregularly closed in the anterior eye and open from the posterior part of the lens to the rear of the optic cup
• in newborns the retinal eversion remains obvious in the unclosed portions of the choroid fissure
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skeleton
N |
• unlike MitfMi homozygotes no skeletal abnormalities are seen
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homeostasis/metabolism
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
MitfMi-wh mutation
(8 available);
any
Mitf mutation
(72 available)
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pigmentation
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• eyes are slightly pigmented
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skeleton
N |
• normal bone development and mice do not develop osteopetrosis
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vision/eye
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• eyes are slightly pigmented
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integument
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
MitfMi-wh mutation
(8 available);
any
Mitf mutation
(72 available)
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MitfMi-wh/+ and MitfMi-wh/MitfMi-wh and control
pigmentation
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• coat color is indistinguishable from that of Tyrc homozygotes
(J:13058)
• the coat is entirely lacking pigment
(J:125080)
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• eyes are pink and pigmentless
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• little or no pigment in the iris
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vision/eye
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• eyes are pink and pigmentless
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• little or no pigment in the iris
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• eye size appears reduced compared to f Tyrc homozygotes
(J:13058)
• the eyes are only mildly reduced in size
(J:125080)
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growth/size/body
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• reduced body size compared to f Tyrc homozygotes
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reproductive system
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• litter size is reduced in homozygous female to homozygous male crosses
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hearing/vestibular/ear
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• no section of the cochlear duct was ever found to be normal
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• abnormal in its entirety
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• the majority of ears show dedifferentiation and cellular migrations in the cochlear duct and the saccule
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nervous system
integument
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• coat color is indistinguishable from that of Tyrc homozygotes
(J:13058)
• the coat is entirely lacking pigment
(J:125080)
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Allelic Composition |
MitfMi-wh/Mitf+
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Genetic Background |
involves: C57BL * DBA |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
MitfMi-wh mutation
(8 available);
any
Mitf mutation
(72 available)
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MitfMi-wh/+
pigmentation
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• coat color is gray and somewhat lighter than that of Myo5ad homozygotes
(J:13058)
• coat color darkens slightly with age
(J:13058)
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• small spots may occur on the back, but spotting is not found on the head
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• reduced foot pigmentation
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• reduced tail pigmentation
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• moderate dilution of the iris pigmentation
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• eyes are a very dark ruby color
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limbs/digits/tail
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• reduced tail pigmentation
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vision/eye
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• moderate dilution of the iris pigmentation
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• eyes are a very dark ruby color
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integument
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• coat color is gray and somewhat lighter than that of Myo5ad homozygotes
(J:13058)
• coat color darkens slightly with age
(J:13058)
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• small spots may occur on the back, but spotting is not found on the head
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• reduced foot pigmentation
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• reduced tail pigmentation
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pigmentation
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• compound heterozygotes are pale yellow with well demarcated white spots on both the dorsum and ventrum
(J:12946)
• at the first moult the hairs that had initially been pale yellow become sooty in color
(J:12946)
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• medullary granules vary greatly in size and shape and are less dense than wild-type
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• the tail, feet, and ears are largely unpigmented although the eyes have pigment
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craniofacial
hearing/vestibular/ear
limbs/digits/tail
integument
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• compound heterozygotes are pale yellow with well demarcated white spots on both the dorsum and ventrum
(J:12946)
• at the first moult the hairs that had initially been pale yellow become sooty in color
(J:12946)
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• medullary granules vary greatly in size and shape and are less dense than wild-type
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• the tail, feet, and ears are largely unpigmented although the eyes have pigment
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growth/size/body
pigmentation
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• agouti mice are light cream with white spots
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vision/eye
integument
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• agouti mice are light cream with white spots
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Allelic Composition |
Mitftm4.1Arnh/MitfMi-wh
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Genetic Background |
involves: 129S4/SvJae * 129S6/SvEvTac * C57BL * C57BL/6N * DBA |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
MitfMi-wh mutation
(8 available);
any
Mitf mutation
(72 available)
Mitftm4.1Arnh mutation
(0 available);
any
Mitf mutation
(72 available)
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pigmentation
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• gray, darkening somewhat with age
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• small spots may occur on the body, but spotting is not found on the head
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integument
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• gray, darkening somewhat with age
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• small spots may occur on the body, but spotting is not found on the head
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Allelic Composition |
Mitftm5.1Arnh/MitfMi-wh
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Genetic Background |
involves: 129S4/SvJae * 129S6/SvEvTac * C57BL * C57BL/6N * DBA |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
MitfMi-wh mutation
(8 available);
any
Mitf mutation
(72 available)
Mitftm5.1Arnh mutation
(0 available);
any
Mitf mutation
(72 available)
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integument
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• considerably darkened compared to heterozygous MitfMi-wh/Mitf+ mice
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pigmentation
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• considerably darkened compared to heterozygous MitfMi-wh/Mitf+ mice
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Allelic Composition |
Mitftm6.1Arnh/MitfMi-wh
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Genetic Background |
involves: 129S4/SvJae * 129S6/SvEvTac * C57BL * C57BL/6N * DBA |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
MitfMi-wh mutation
(8 available);
any
Mitf mutation
(72 available)
Mitftm6.1Arnh mutation
(0 available);
any
Mitf mutation
(72 available)
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pigmentation
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• slightly darker coat color
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integument
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• slightly darker coat color
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Allelic Composition |
Mitftm7Arnh/MitfMi-wh
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Genetic Background |
involves: 129S6/SvEvTac * C57BL * C57BL/6N * DBA |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
MitfMi-wh mutation
(8 available);
any
Mitf mutation
(72 available)
Mitftm7Arnh mutation
(0 available);
any
Mitf mutation
(72 available)
|
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Allelic Composition |
Mitftm4Arnh/MitfMi-wh
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Genetic Background |
involves: 129S6/SvEvTac * C57BL * C57BL/6N * DBA |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
MitfMi-wh mutation
(8 available);
any
Mitf mutation
(72 available)
Mitftm4Arnh mutation
(0 available);
any
Mitf mutation
(72 available)
|
|
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
MitfMi-wh mutation
(8 available);
any
Mitf mutation
(72 available)
Mitftm7.1Arnh mutation
(0 available);
any
Mitf mutation
(72 available)
|
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Allelic Composition |
Mitftm5Arnh/MitfMi-wh
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Genetic Background |
involves: 129S6/SvEvTac * C57BL * C57BL/6N * DBA |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
MitfMi-wh mutation
(8 available);
any
Mitf mutation
(72 available)
Mitftm5Arnh mutation
(0 available);
any
Mitf mutation
(72 available)
|
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Allelic Composition |
Mitftm6Arnh/MitfMi-wh
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Genetic Background |
involves: 129S6/SvEvTac * C57BL * C57BL/6N * DBA |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
MitfMi-wh mutation
(8 available);
any
Mitf mutation
(72 available)
Mitftm6Arnh mutation
(0 available);
any
Mitf mutation
(72 available)
|
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
MitfMi-wh mutation
(8 available);
any
Mitf mutation
(72 available)
Mitfmi-x mutation
(0 available);
any
Mitf mutation
(72 available)
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vision/eye
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• eyelid closure is of variable extent
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mortality/aging
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• most die at 3-4 weeks of age, although some survive to adulthood
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pigmentation
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• mice are white; similar to MitfMi-wh/Mi-wh mice
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growth/size/body
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• smaller and more runted than single homozygotes
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skeleton
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• bones show signs of osteopetrosis with intermediate extensions of bony trabeculae; less severe than in homozygous Tcfe3tm1Est mice with other Mitf mutations
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vision/eye
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• similar to MitfMi-wh/Mi-wh mice
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integument
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• mice are white; similar to MitfMi-wh/Mi-wh mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
MitfMi-wh mutation
(8 available);
any
Mitf mutation
(72 available)
Tfectm1Est mutation
(0 available);
any
Tfec mutation
(25 available)
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pigmentation
skeleton
N |
• osteopetrosis is not observed amd bone development appears normal
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vision/eye
integument
pigmentation
skeleton
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• mice develop osteopetrosis similar to that observed in double MitfMi-wh and Tcfe3tm1Est mutants
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vision/eye
integument
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
MitfMi-wh mutation
(8 available);
any
Mitf mutation
(72 available)
Tfebtm1Est mutation
(0 available);
any
Tfeb mutation
(45 available)
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pigmentation
skeleton
N |
• mutants do not develop osteopetrosis
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vision/eye
integument
pigmentation
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• coat color is pastel gray or silver
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vision/eye
integument
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• coat color is pastel gray or silver
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