Tfe3^tm1Est
Targeted Allele Detail

Summary

• Symbol: Tfe3^tm1Est
• Name: transcription factor E3; targeted mutation 1, Eirikur Steingrimsson
• MGI ID: MGI:3044119
• Synonyms: Tcfe3-, Tfe3^Fcr
• Gene: Tfe3 Location: ChrX:7628799-7641441 bp, + strand Genetic Position: ChrX, 3.5 cM, cytoband A2
• Alliance: Tfe3^tm1Est page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89821
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 5.5 kb genomic fragment encompassing 7 exons and encoding the bHLH-Zip domains was replaced with a PGK-neo cassette inserted by homologous recombination. Transcript was undetected by RT-PCR analysis of renal RNA obtained from hemizygous mutant mice. (J:89821)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tfe3 Mutation: 21 strains or lines available

References

• Original: J:89821 Steingrimsson E, et al., Mitf and Tfe3, two members of the Mitf-Tfe family of bHLH-Zip transcription factors, have important but functionally redundant roles in osteoclast development. Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4477-82
• All: 15 reference(s)