Analysis Tools
mortality/aging
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• incidence is correlated with degree mice are affected by deteriorating skin condition
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behavior/neurological
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• majority of mice are mute
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reproductive system
cryptorchism
(
J:13065
)
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• most males fail to develop a scrotum
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• severity of skin condition displaces vaginal opening over pubic symphysis
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• most males fail to develop a scrotum
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• cryptorchid males are invariable sterile
• however, males with one or both testes descended are usually fertile
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cellular
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• chromatin in leucocytes and many other cells types is clumped
• cells of mutant mice contain about 10% more DNA than normal sibs
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tail necrosis
(
J:13065
)
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• tail may develop multiple constrictions with loss of tail tip through necrosis
|
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• found in epidermis
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endocrine/exocrine glands
cryptorchism
(
J:13065
)
|
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• most males fail to develop a scrotum
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respiratory system
growth/size/body
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• mutant mice grow more slowly than normal sibs
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integument
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• by the second week mice have a thin, short coat of curly hair instead of a full coat
• coats of older mice range from a thin, fuzzy coat to completely bare
• at 6 days there is only fluffy down on head and neck; dorsal guard hairs are scarsely visible
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• whiskers of 2-day-old are shorter than normal
• at 3 days arrangement is irregular, some curved or criss-crossed
• whiskers are short and heavily curled by 2 weeks of age
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• dermal and epidermal recombination experiments indicate this locus acts in the epidermis
• dilated intercellular junctions found between the stratum spinosum and stratum granulosum are packed with membrane-coating and amorphous material
• contains excessively clumped tonofilaments and incresed numbers of mitochondria
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• this layer was thickened
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• this layer is more prominent than in normal sibs
• ultrastructural analysis showed profuse keratin-forming structures, abnormally large keratohyaline granules, and persistent mitochondria
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• abnormally large keratohyaline granules
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scaly skin
(
J:13065
)
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• individuals show variation in severity; in the most serious cases scales form rigid plates restricting movement and respiration
• during weeks 3 and 4, the skin dries, hardens, and is progressively sloughed in an anteriorposterior, dorsoventral pattern
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limbs/digits/tail
tail necrosis
(
J:13065
)
|
• tail may develop multiple constrictions with loss of tail tip through necrosis
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