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Lbric
Spontaneous Allele Detail
Summary
Symbol: Lbric
Name: lamin B receptor; ichthyosis
MGI ID: MGI:1856063
Synonyms: ic
Gene: Lbr  Location: Chr1:181642880-181669966 bp, - strand  Genetic Position: Chr1, 84.89 cM
Alliance: Lbric page
Mutation
origin
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Spontaneous
Mutation:    Single point mutation
 
Mutation detailsA spontaneous mutation that arose in a sib-mated stock at Edinburgh in 1948. The mutation in the ic mouse was identified as a transition (523C>T) that introduces a premature stop codon at the glutamine codon at position 175 (p.Q175*).
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 9 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Lbric
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lbr Mutation:  55 strains or lines available
References
Original:  J:64274 Carter TC, et al., ic - ichthyosis. Mouse News Lett. 1949;1S:1
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
07/05/2024
MGI 6.24
The Jackson Laboratory