craniofacial
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• longitudinal ridges on forehead
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endocrine/exocrine glands
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• SEM shows marked plugging of the gland orifice with keratinized cells or debris
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• by one year of age Meibomian glands are distorted by large dermal cysts
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• marked loss or atrophy of the acinar component of the gland seen at 3 and 6 months of age
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• seen at 1 year of age due hyperkeratinization of the gland's central duct
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• milk supply is insufficient to raise young but pups will thrive on foster-mother
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growth/size/body
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• longitudinal ridges on forehead
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• by one year of age Meibomian glands are distorted by large dermal cysts
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• large doses of Vitamin A prevents enlargement of cysts
(J:13008)
• cysts are in such large numbers the skin area is greatly increased and consequently wrinkled
(J:14940)
• cysts are larger than in homozygous Hrhr mice
(J:14940)
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vision/eye
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• the ocular surface is covered with whitish exudate and increased numbers of preexfoliative corneal epithelial cells
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• at 6 months of age, affected eyelids appear thickened or swollen
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• SEM shows marked plugging of the gland orifice with keratinized cells or debris
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• by one year of age Meibomian glands are distorted by large dermal cysts
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• marked loss or atrophy of the acinar component of the gland seen at 3 and 6 months of age
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• seen at 1 year of age due hyperkeratinization of the gland's central duct
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• at 6 months of age, eyelid cilia are absent
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• the lid margin is not uniform or smooth but instead appears nodular with multiple swellings
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immune system
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• the ocular surface is covered with whitish exudate and increased numbers of preexfoliative corneal epithelial cells
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integument
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• SEM shows marked plugging of the gland orifice with keratinized cells or debris
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• by one year of age Meibomian glands are distorted by large dermal cysts
|
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• marked loss or atrophy of the acinar component of the gland seen at 3 and 6 months of age
|
|
• seen at 1 year of age due hyperkeratinization of the gland's central duct
|
|
• milk supply is insufficient to raise young but pups will thrive on foster-mother
|
|
• large doses of Vitamin A prevents enlargement of cysts
(J:13008)
• cysts are in such large numbers the skin area is greatly increased and consequently wrinkled
(J:14940)
• cysts are larger than in homozygous Hrhr mice
(J:14940)
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• by 7 weeks of age mouse is completely hairless
• no regeneration occurs
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• at 6 months of age, eyelid cilia are absent
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• a ventral curvature forces mice to walk on the hind part of the foot, impeding movement
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• by 5 weeks of age nail overgrowth is observed on claws of all four feet
• overgrowth continues with age and may be more than a centimeter in length
• overgrowth is greater in males than females, especially on the forefeet
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• the skin has deformed, non-hair bearing follicles that are distended with horny material made of multiple layers of corneocytes
• topical treatment with all-trans retinoic acid: diminishes the contents of the distended follicles and thickens the follicular epithelium to 4-6 layers by 2 days of treatment; normalizes many of the follicles, with the follicular epithelium thickening to 10 cell layers, by 3 days of treatment; and normalizes all follicular structures by 6 days of treatment
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• this extensive condition in hair follicles produces hair canal cysts
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• caused by formation of sebaceous-gland and follicle-end cysts
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• transverse ridges on nose, back and belly
• longitudinal ridges on forehead
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• at 3 weeks of age mice begin to show wrinkling of skin
• changes are patterned with transverse ridges on nose, back and belly; longitudinal ridges on forehead; a lateral fold on abdomen from foreleg to hindleg
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limbs/digits/tail
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• by 5 weeks of age nail overgrowth is observed on claws of all four feet
• overgrowth continues with age and may be more than a centimeter in length
• overgrowth is greater in males than females, especially on the forefeet
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