Phenotypes associated with this allele

• Allele Symbol: Axin1^Fu-ki
• Allele Name: kinky
• Allele ID: MGI:1856036
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Axin1^Fu-ki/Axin1^Fu-ki	involves: Bagg albino * CF * fancier's mice	MGI:3795122
hm2	Axin1^Fu-ki/Axin1^Fu-ki	involves: BTBR	MGI:3663637
hm3	Axin1^Fu-ki/Axin1^Fu-ki	mixed	MGI:3663590
ht4	Axin1^Fu-ki/Axin1^+	mixed	MGI:3663589
ht5	Axin1^Fu-ki/Axin1^Fu-Tg1	involves: BTBR * C57BL/6J * CBA/J	MGI:3663641

Genotype
MGI:3795122

hm1

• Allelic Composition: Axin1^Fu-ki/Axin1^Fu-ki
• Genetic Background: involves: Bagg albino * CF * fancier's mice

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:13017 )

• most homozygotes are still alive at embryonic day 9, but the majority are dead by day 10 and all are dead by day 12

embryo

rostral-caudal axis duplication ( J:13017 )

• instances are found of complete or partial duplication of the entire embryonic axis, or of individual organs such as the heart, or extraneous growth of a lump of tissue, or doubled neural folds

embryonic growth retardation ( J:13017 )

• seen in day 8 embryos

abnormal embryonic tissue morphology ( J:13017 )

• 8 day embryos can have hyperplasia of neuroectoderm and mesenchyme yielding folds protruding into the amniotic cavity, 9 day embryos frequently have more contorted headfolds and neural folds

split notochord ( J:13017 )

small tail bud ( J:13017 )

• 9 day embryos have abnormally small tail buds

disorganized embryonic tissue ( J:13017 )

abnormal extraembryonic tissue morphology ( J:13017 )

• 8 and 9 day embryos frequently have abnormal embryonic membranes and some embryos are found outside of the yolk sac

abnormal allantois morphology ( J:13017 )

• instances of multiple allantoides are found

growth/size/body

embryonic growth retardation ( J:13017 )

• seen in day 8 embryos

limbs/digits/tail

small tail bud ( J:13017 )

• 9 day embryos have abnormally small tail buds

Genotype
MGI:3663637

hm2

• Allelic Composition: Axin1^Fu-ki/Axin1^Fu-ki
• Genetic Background: involves: BTBR

nervous system

kinked neural tube ( J:28303 )

embryo

abnormal cephalic neural fold morphology ( J:28303 )

• malformed head folds

kinked neural tube ( J:28303 )

Genotype
MGI:3663590

hm3

• Allelic Composition: Axin1^Fu-ki/Axin1^Fu-ki
• Genetic Background: mixed

mortality/aging

prenatal lethality ( J:13056 )

Genotype
MGI:3663589

ht4

• Allelic Composition: Axin1^Fu-ki/Axin1⁺
• Genetic Background: mixed

limbs/digits/tail

abnormal caudal vertebrae morphology ( J:13056 )

• some vertebrae show abnormalities in structure, with one side shorter than the other, causing the following vertebra to form an angle with it

caudal vertebral fusion ( J:13056 )

• two neighboring vertebrae may be fused, producing stiff tail segments

decreased caudal vertebrae number ( J:13056 )

short tail ( J:13056 )

• may be reduced to as little as 1/2 of normal length

bifurcated tail ( J:13056 )

• occasionally observe bifurcations of the tail

kinked tail ( J:13056 )

• variable tail flexure, ranging from a barely perceptible bend or bump to a strong spiral twist

skeleton

rib fusion ( J:13056 )

• partial and total rib fusions due to reductions of vertebrae

abnormal vertebrae morphology ( J:13056 )

abnormal caudal vertebrae morphology ( J:13056 )

• some vertebrae show abnormalities in structure, with one side shorter than the other, causing the following vertebra to form an angle with it

caudal vertebral fusion ( J:13056 )

• two neighboring vertebrae may be fused, producing stiff tail segments

decreased caudal vertebrae number ( J:13056 )

abnormal thoracic vertebrae morphology ( J:13056 )

• abnormalities include eccentric reductions of single vertebrae

thoracic vertebral fusion ( J:13056 )

• ankyloses between adjacent vertebrae

abnormal lumbar vertebrae morphology ( J:13056 )

• abnormalities include eccentric reductions of single vertebrae

lumbar vertebral fusion ( J:13056 )

• ankyloses between adjacent vertebrae

abnormal sacral vertebrae morphology ( J:13056 )

• abnormalities include eccentric reductions of single vertebrae

sacral vertebral fusion ( J:13056 )

• ankyloses between adjacent vertebrae

Genotype
MGI:3663641

ht5

• Allelic Composition: Axin1^Fu-ki/Axin1^Fu-Tg1
• Genetic Background: involves: BTBR * C57BL/6J * CBA/J

cardiovascular system

enlarged pericardium ( J:28303 )

• expanded pericardium

embryo

embryonic growth retardation ( J:28303 )

• seen at E9.5

abnormal cephalic neural fold morphology ( J:28303 )

• E9.5 embryos exhibit poorly formed head folds and/or large globular mass attached to the head folds

abnormal allantois morphology ( J:28303 )

growth/size/body

flat head ( J:28303 )

• E9.5 embryos exhibit a flattened head

embryonic growth retardation ( J:28303 )

• seen at E9.5

craniofacial

flat head ( J:28303 )

• E9.5 embryos exhibit a flattened head