Depp1^em1Jmz
Endonuclease-mediated Allele Detail

Summary

• Symbol: Depp1^em1Jmz
• Name: DEPP1 autophagy regulator; endonuclease-mediated mutation 1, Jeffrey M Zigman
• MGI ID: MGI:8409558
• Synonyms: Depp1^delta, DKOe
• Gene: Depp1 Location: Chr6:116627645-116629808 bp, + strand Genetic Position: Chr6, 53.83 cM
• Alliance: Depp1^em1Jmz page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details:

  CRISPR/Cas9-mediated recombination with guide RNAs targeting intron 1 and a region downstream of exon 2 generated a deletion spanning positions 2120-3274 and encompassing the translational start site and adjacent coding region within exon 2. qRT-PCR confirmed the loss of mRNA expression. (J:389887)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Depp1 Mutation: 20 strains or lines available

References

• Original: J:389887 Sheybani-Deloui S, et al., Loss of the calorie restriction response protein DEPP1 worsens diet-induced obesity. Endocrinology. 2026 Jul 8;167(8)
• All: 1 reference(s)