Phenotypes associated with this allele

• Allele Symbol: Depp1^em1Jmz
• Allele Name: endonuclease-mediated mutation 1, Jeffrey M Zigman
• Allele ID: MGI:8409558
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Depp1^em1Jmz/Depp1^em1Jmz	C57BL/6N-Depp1^em1Jmz	MGI:8409577

Genotype
MGI:8409577

hm1

• Allelic Composition: Depp1^em1Jmz/Depp1^em1Jmz
• Genetic Background: C57BL/6N-Depp1^em1Jmz

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased susceptibility to diet-induced obesity ( J:389887 )

♂ • 4-week-old male mice fed a high-fat diet (HFD) for 16 weeks exhibit a higher body weight than wild-type mice, reaching a 13.8% increase by week 16

♂ • however, females fed a HFD show no differences in body weight

impaired glucose tolerance ( J:389887 )

♂ • after 16 weeks on a HFD, mice show impaired glucose tolerance, with elevated glucose levels at all time points during the oral glucose tolerance test and a 15% increase in glucose area under the curve

♂ • however, insulin sensitivity assessed by insulin tolerance test is not altered in HFD-fed mice

adipose tissue

increased body fat mass ( J:389887 )

♂ • HFD-fed mice exhibit greater fat mass from week 8 onward, with a pronounced difference (19.6% higher) at week 16

increased white fat cell size ( J:389887 )

♂ • HFD-fed mice exhibit enlarged adipocytes in epididymal white adipose tissue (eWAT)

behavior/neurological

increased food intake ( J:389887 )

♂ • average weekly food intake is increased by 9.4% and cumulative food intake is elevated by 9.8% in mice fed a HFD, while cumulative feed efficiency is comparable to wild-type mice, indicating that diet-induced obesity is driven primarily by hyperphagia and not decreased energy expenditure

♂ • however, males exhibit normal circulating ghrelin concentrations under HFD, indicating that hyperghrelinemia does not account for the hyperphagic phenotype

growth/size/body

growth/size/body region phenotype ( J:389887 )

♂N • calorie restricted male mice exhibit comparable changes in body weight, adiposity, percent lean mass, and progressive fall in blood glucose as wild-type mice

increased body fat mass ( J:389887 )

♂ • HFD-fed mice exhibit greater fat mass from week 8 onward, with a pronounced difference (19.6% higher) at week 16

increased lean body mass ( J:389887 )

♂ • HFD-fed mice exhibit a modestly higher (6.7%) lean mass at week 16

increased susceptibility to diet-induced obesity ( J:389887 )

♂ • 4-week-old male mice fed a high-fat diet (HFD) for 16 weeks exhibit a higher body weight than wild-type mice, reaching a 13.8% increase by week 16

♂ • however, females fed a HFD show no differences in body weight

liver/biliary system

increased susceptibility to diet-induced hepatic steatosis ( J:389887 )

♂ • HFD-fed mice exhibit increased hepatic steatosis and lipid accumulation