Eya3^em1Rsheg
Endonuclease-mediated Allele Detail

Summary

• Symbol: Eya3^em1Rsheg
• Name: EYA transcriptional coactivator and phosphatase 3; endonuclease-mediated mutation 1, Rashmi S Hegde
• MGI ID: MGI:8403171
• Synonyms: Eya3^D262N
• Gene: Eya3 Location: Chr4:132366303-132452076 bp, + strand Genetic Position: Chr4, 65.68 cM
• Alliance: Eya3^em1Rsheg page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Single point mutation
• Mutation details:

  Aspartic acid codon 262 (GAC) was changed to asparagine (AAC) (p.D262N) using an sgRNA and an ssODN template with CRISPR/Cas9 technology. The mutation abrogate the tyrosine phosphatase activity of the encoded protein. (J:279462)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Eya3 Mutation: 398 strains or lines available

References

• Original: J:279462 Wang Y, et al., The EYA3 tyrosine phosphatase activity promotes pulmonary vascular remodeling in pulmonary arterial hypertension. Nat Commun. 2019 Sep 12;10(1):4143
• All: 1 reference(s)