Ftx^tm1.2Ics
Targeted Allele Detail

Summary

• Symbol: Ftx^tm1.2Ics
• Name: Ftx transcript, Xist regulator, non-protein coding; targeted mutation 1.2, Mouse Clinical Institute
• MGI ID: MGI:8280706
• Synonyms: Ftx^-
• Gene: Ftx Location: ChrX:102604516-102667360 bp, - strand Genetic Position: ChrX, 46.21 cM
• Alliance: Ftx^tm1.2Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:378077
• Parent Cell Line: BD10 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site and an F3 site flanked hygromycin resistance gene cassette were inserted upstream of exon 1 (ENSMUSE00000779650). An FRT site flanked neomycin resistance gene cassette and a second loxP site were inserted into intron 2 (downstream of exon ENSMUSE00000838436). The hygro and neo cassette were removed through subsequent Flp-mediated recombination and the 12.7 kb targeted region, including the Ftx promoter region and exons 1-2, was deleted through subsequent Cre-mediated recombination. (J:378077)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ftx Mutation: 6 strains or lines available

References

• Original: J:378077 Huret C, et al., Altered X-chromosome inactivation predisposes to autoimmunity. Sci Adv. 2024 May 3;10(18):eadn6537
• All: 1 reference(s)